Abstract
Understanding protein folding and unfolding mechanisms are a central problem in molecular biology. Data obtained from molecular dynamics unfolding simulations may provide valuable insights for a better understanding of these mechanisms. Here, we propose the application of an augmented version of hierarchical clustering analysis to detect clusters of amino-acid residues with similar behavior in protein unfolding simulations. These clusters hold similar global pattern behavior of solvent accessible surface area (SASA) variation in unfolding simulations of the protein Transthyretin (TTR). Classical hierarchical clustering was applied to build a dendrogram based on the SASA variation of each amino-acid residue. The dendrogram was enriched with background information on the amino-acid residues, enabling the extraction of sub-clusters with well differentiated characteristics.

Abstract
The basic statistical features of radon time series from continuous radon monitoring at the Elat granite, Israel are analysed. A similar analysis is carried out for ancillary and possibly related geophysical parameters for the Elat area. The results show that air temperature, precipitable water and longwave radiation time series exhibit constant variance over the analyzed period, while radon time series, atmospheric pressure, short-wave radiation and total electron content exhibit heteroscedasticity. Furthermore, for radon and shortwave radiation the variability is associated with the overall mean level, while for atmospheric pressure such an association is not present. The analyzed radon time series not only are non-stationary but also nonlinear, reflecting the complex dynamics of radon emanation and transport in natural subsurface systems.

Abstract
A comparative study is carried out for sea level observations in the North Atlantic from tide gauges and satellite altimetry. Monthly tide gauge records from 12 stations in both sides of the North Atlantic from January 1993 to December 2003 and monthly time series of sea level anomalies derived from TOPEX measurements are considered. The degree of association between tide gauge and altimetry observations is analysed for different scales by computing the correlation between the sea level components resulting from a multiresolution analysis based on the maximal overlap discrete wavelet transform. A similar correlation analysis is carried out to assess the relationship between the sea level observations and climate variables: sea surface temperature, precipitation rate and wind speed. The results show that altimetry and tide gauge observations are strongly correlated, as expected, but also that the relation is scale dependent, with covariability driven by the seasonal signal for most stations. For all variables the obtained correlation patterns exhibit significant spatial variability reflecting the diversity of local conditions affecting coastal sea level.

Abstract
Heart rate variability (HRV) data display non-stationary characteristics and exhibit long-range correlation (memory). Detrended fluctuation analysis (DFA) has become a widely-used technique for long memory estimation in non-stationary HRV data. Recently, we have proposed an alternative approach based on fractional integrated autoregressive moving average (ARFIMA) models. ARFIMA models, combined with selective adaptive segmentation may be used to capture and remove long-range correlation, leading to an improved description and interpretation of tire components in 24 hour HRV recordings. In this work estimation of long memory by DFA and selective adaptive ARFIMA modelling is carried out in 24 hour HRV recordings of 17 healthy subjects of two age groups. The two methods give similar information on long-range global characteristics. However ARFIMA modelling is advantageous, allowing the description of long-range correlation in reduced length segments.

Abstract
We propose an approach to subgroup discovery using distribution rules (a kind of association rules with a probability distribution on the consequent) for numerical properties of interest. The objective interest of the subgroups is measured through statistical goodness of fit tests. Their subjective interest can be assessed by the data analyst through a visual interactive subgroup browsing procedure.

Abstract
This paper describes the study on example selection in regression problems using mu-SVM (Support Vector Machine) linear as prediction algorithm. The motivation case is a study done on real data for a problem of bus trip time prediction. In this study we use three different training sets: all the examples, examples from past days similar to the day where prediction is needed, and examples selected by a CART regression tree. Then, we verify if the CART based example selection approach is appropriate on different regression data sets. The experimental results obtained are promising.