Abstract
Lung cancer remains the leading cause of cancer related deaths globally, responsible for approximately 1.8 million deaths each year. A key contributor to this high mortality rate is the late-stage diagnosis of the disease, underscoring the urgent need for effective early detection strategies. Low-dose computed tomography (CT) has shown great value in early screening, particularly when paired with clinical information. Clinical data, while valuable, lacks spatial and morphological insights essential for comprehensive evaluation. Combining both modalities offers a more holistic approach for lung cancer classification. This study presents AI-based methods for lung cancer classification using unimodal approaches - structured clinical data and chest CT imaging - alongside a novel multimodal deep learning framework that integrates both data types to classify lung nodules as malignant or benign. For the clinical modality, machine learning models including logistic regression, random forests, LightGBM, XGBoost, and multilayer perceptrons were evaluated with extensive hyperparameter tuning. In the imaging modality, ResNet18 and ResNet34 convolutional neural networks were used, with and without data augmentation. The study explored both intermediate and late fusion strategies to combine modality-specific representations. Results show that multimodal models consistently outperformed their unimodal counterparts, achieving a best-case area under the ROC curve (AUC) of 0.9138, with an accuracy of 0.8424 and an F1-score of 0.8422. These findings highlight the complementary strengths of imaging and clinical data and support the growing potential of multimodal deep learning in improving diagnostic accuracy in lung cancer classification. © 2025 IEEE.

Abstract
The Vision Transformer (ViT) architecture has emerged as a potential game-changer in computer vision, offering scalability and global attention that have generated considerable interest in recent years. Its adaptability has fueled enthusiasm for its application. This work investigates the boundaries of the architecture, focusing on developing new techniques targeting explicitly complex tasks, such as medical imaging datasets, which often exhibit high variability, class imbalance, and limited sample sizes. We propose a set of mixed regularisation and augmentation techniques to enhance the performance of models. These include a novel loss function and a smoothly differentiable activation function, leading to more stable training and model performance. The results show that incorporating these techniques improves model performance and training convergence.

Abstract
Epidermal Growth Factor Receptor (EGFR) is one of the most frequently mutated genes in lung cancer. Its mutation status characterization is crucial for personalized treatment in Non-Small-Cell Lung Cancer (NSCLC). Biopsy is the gold standard for characterizing the EGFR mutation status. However, it is an invasive time-consuming method and is often burdensome or even impractical for some patients. Therefore, it is of utmost importance to identify alternative non-invasive methods for classifying this mutation. Computed Tomography (CT) images represent a non-invasive, safer and faster method to directly characterize lung cancer. This study developed a comprehensive radiomic approach for EGFR mutation classification using CT images, in which two preprocessing strategies were compared and five machine learning algorithms were evaluated across different datasets. We analyzed two independent datasets individually and combined, implementing lung containing nodule versus bounding box around nodule preprocessing approaches. Radiomic features were extracted using PyRadiomics and selected through Principal Component Analysis (PCA) (65-95% variance thresholds) and pairwise correlation filtering. The results demonstrated that the lung with nodule strategy achieved better and more consistent performance compared to the bounding box around the nodule method. The best performance (AUC=0.780) was achieved using Random Forest with correlation filtering. The results suggest that radiomics may be a potential support tool for EGFR classification when biopsy is not feasible or recommended. This would enable safer and more efficient personalized treatment. Nevertheless, the results underscore the need for larger, diverse datasets to improve model robustness for characterizing such complex and variable information before clinical integration. © 2025 IEEE.

Abstract
Modulation instability (MI) of the continuous wave (cw) has been associated with the onset of stable solitons in conservative and dissipative systems. The cubic complex Ginzburg-Landau equation (CGLE) is a prototype of a damped, driven, nonlinear, and dispersive system. The inclusion of nonlinear gradients is essential to stabilize pulses whether stationary or oscillatory. The soliton solutions of this model have been reasonably studied; however, its cw solution characteristics and stability have not been reported yet. Here, we obtain the cw solutions of the cubic CGLE with nonlinear gradient terms and study its short- and long-term evolution under the effect of small perturbations. We have found that, for each admissible amplitude, there are two branches of cw solutions, and all of them are unstable. Then, through direct integration of the evolution equation, we study the evolution of those cw solutions, observing the emergence of plain and oscillatory solitons. Depending on whether the cw and/or its perturbation are sinusoidal, we can obtain a train of a finite number of pulses or bound states.

Abstract
Measuring the density of tartrazine (TZ) powder allowed to develop a protocol for fast preparation of aqueous solutions with a desired concentration. The stability time of these solutions decreases exponentially with the increase of TZ concentration: solutions with TZ concentrations below 25% remain stable for more than 24 h, while the solution with 60% TZ remains stable only for 35 min. To validate the developed protocol, muscle samples were immersed in the 40% TZ solution and, as expected, the tissue transparency increased smoothly and exponentially during the whole treatment of 30 min. The diffusion time of TZ in ex vivo skeletal muscle was quantitatively determined with high accuracy as tau TZ = 5.39 +/- 0.49 min for sample thickness of 0.5 mm. By measuring the refractive index of TZ solutions during preparation, it will be easier to prepare such solutions in a fast manner for future research on tissue optical clearing.

Abstract
We studied the characteristics, regions of existence, and stability of different types of solitons for a distributed model of a mode-locked laser whose dispersion is purely quartic and normal. Among the different types of solitons, we identified three main branches that are named according to their different amplitude: low, medium, and high amplitude solitons. It was found that the first solitons are always unstable while the latter two exist and are stable in relatively large regions of the parameter space. Moreover, the stability regions of medium and high amplitude solitons overlap over a certain range of parameters, manifesting effects of bistability. The energy of high amplitude solitons increases quadratically with their width, whereas the energy of medium amplitude solitons may decrease or increase with the width depending on the parameter region. Furthermore, we have investigated the long term evolution of the continuous-wave solutions under modulational instability, showing that medium amplitude solitons can arise in this scenario. Additionally, we assessed the effects of second- and third-order dispersion on medium and high amplitude solitons and found that both remain stable in the presence of these terms.