Detalhes
Nome
João Paulo CunhaCluster
Redes de Sistemas InteligentesCargo
Coordenador de CentroDesde
01 janeiro 2013
Nacionalidade
PortugalCentro
Centro de Investigação em Engenharia BiomédicaContactos
+351222094106
joao.p.cunha@inesctec.pt
2023
Autores
Narciso, D; Melo, M; Rodrigues, S; Cunha, JP; Vasconcelos-Raposo, J; Bessa, M;
Publicação
IEEE Transactions on Visualization and Computer Graphics
Abstract
2022
Autores
Faria, MT; Rodrigues, S; Campelo, M; Dias, D; Rego, R; Rocha, H; Sa, F; Tavares Silva, M; Pinto, R; Pestana, G; Oliveira, A; Pereira, J; Cunha, JPS; Rocha Goncalves, F; Goncalves, H; Martins, E;
Publicação
EPILEPSY & BEHAVIOR
Abstract
Objective: Heart rate variability (HRV), an index of the autonomic cardiac activity, is decreased in patients with epilepsy, and a low HRV is associated with a higher risk of sudden death. Generalized tonic-clonic seizures are one of the most consistent risk factors for SUDEP, but the influence (and relative risk) of each type of seizure on cardiac function is still unknown. Our objective was to assess the impact of the type of seizure (focal to bilateral tonic-clonic seizure – FBTCS – versus non-FBTCS) on periictal HRV, in a group of patients with refractory epilepsy and both types of seizures. Methods: We performed a 48-hour Holter recording on 121 patients consecutively admitted to our Epilepsy Monitoring Unit. We only included patients with both FBTCS and non-FBTCS on the Holter recording and selected the first seizure of each type to analyze. To evaluate HRV parameters (AVNN, SDNN, RMSSD, pNN20, LF, HF, and LF/HF), we chose 5-min epochs pre- and postictally. Results: We included 14 patients, with a median age of 36 (min–max, 16–55) years and 64% were female. Thirty-six percent had cardiovascular risk factors, but no previously known cardiac disease. In the preictal period, there were no statistically significant differences in HRV parameters, between FBTCS and non-FBTCS. In the postictal period, AVNN, RMSSD, pNN20, LF, and HF were significantly lower, and LF/HF and HR were significantly higher in FBTCS. From preictal to postictal periods, FBTCS elicited a statistically significant rise in HR and LF/HF, and a statistically significant fall in AVNN, RMSSD, pNN20, and HF. Non-FBTCS only caused statistically significant changes in HR (decrease) and AVNN (increase). Significance/conclusion: This work emphasizes the greater effect of FBTCS in autonomic cardiac function in patients with refractory epilepsy, compared to other types of seizures, with a significant reduction in vagal tonus, which may be associated with an increased risk of SUDEP. © 2021 Elsevier Inc.
2022
Autores
Dias, D; Silva, J; Oliveira, N; Massano, J; Cunha, JPS;
Publicação
2022 IEEE 21ST MEDITERRANEAN ELECTROTECHNICAL CONFERENCE (IEEE MELECON 2022)
Abstract
2022
Autores
Lopes, EM; Rego, R; Rito, M; Chamadoira, C; Dias, D; Cunha, JPS;
Publicação
SENSORS
Abstract
2022
Autores
Vilas-Boas, MD; Fonseca, PFP; Sousa, IM; Cardoso, MN; Cunha, JPS; Coelho, T;
Publicação
JOURNAL OF CLINICAL MEDICINE
Abstract
Hereditary amyloidosis associated with transthyretin (ATTRv), is a rare autosomal dominant disease characterized by length-dependent symmetric polyneuropathy that has gait impairment as one of its consequences. The gait pattern of V30M ATTRv amyloidosis patients has been described as similar to that of diabetic neuropathy, associated with steppage, but has never been quantitatively characterized. In this study we aim to characterize the gait pattern of patients with V30M ATTRv amyloidosis, thus providing information for a better understanding and potential for supporting diagnosis and disease progression evaluation. We present a case series in which we conducted two gait analyses, 18 months apart, of five V30M ATTRv amyloidosis patients using a 12-camera, marker based, optical system as well as six force platforms. Linear kinematics, ground reaction forces, and angular kinematics results are analyzed for all patients. All patients, except one, showed a delayed toe-off in the second assessment, as well as excessive pelvic rotation, hip extension and external transverse rotation and knee flexion (in stance and swing phases), along with reduced vertical and mediolateral ground reaction forces. The described gait anomalies are not clinically quantified; thus, gait analysis may contribute to the assessment of possible disease progression along with the clinical evaluation.
Teses supervisionadas
2022
Autor
Ana Filipa de Sousa Ferreira
Instituição
UP-FEUP
2022
Autor
Tiago Mourão Pires
Instituição
UP-FEP
2022
Autor
Duarte Teixeira Rodrigues
Instituição
UP-FEUP
2022
Autor
Elodie Múrias Lopes
Instituição
UP-FEUP
2022
Autor
Eduardo Ferreira Campos
Instituição
UP-FEUP
The access to the final selection minute is only available to applicants.
Please check the confirmation e-mail of your application to obtain the access code.