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Sobre

Sobre

Sou Mestre em Engenharia Informática e Computação, tendo frequentado o curso que antes do processo de Bolonha era designado por LEIC (Licenciatura em Engenharia Informática e Computação), no qual ingressei, na Faculdade de Engenharia da Universidade do Porto (FEUP), em 2001. No ano letivo de 2006/2007 tive o meu primeiro contacto com o INESC, no 2º semestre, através do estágio de fim de curso, na antiga UTM, sob orientação do Prof. Jaime Cardoso. No ano de 2007 decorreu a transição do curso LEIC para MIEIC (Mestrado Integrado em Engenharia Informática e Computação), na FEUP, e foi dada a possibilidade aos alunos para concluírem o curso como LEIC ou continuarem como MIEIC. Pensando no meu futuro optei por continuar no novo curso, realizando a respetiva dissertação, sob a mesma orientação no INESC, tendo concluído em 2008 com o grau de Mestre.

Fui bolseiro no ano de 2008 e em 2009 não estive associado ao INESC, mas em Dezembro desse ano regressei, mas numa outra unidade, a antiga USIG, agora designada por CSIG, sob orientação do Engº José Correia, na qual permaneço até à atualidade.

No meu percurso no INESC Porto - agora INESC TEC -, participei em vários projetos e atividades de diferentes âmbitos e objetivos, desde investigação a prestação de serviços, nomeadamente com a realização de desenvolvimento e participação em projetos de consultoria, tendo inclusive adquirido ao longo deste percurso novos conhecimentos e capacidades que fortaleceram as minhas competências. Nos trabalhos de investigação houve publicação de artigos científicos e participação em conferências.

Tópicos
de interesse
Detalhes

Detalhes

  • Nome

    Guilherme Artur Capela
  • Cluster

    Informática
  • Cargo

    Investigador
  • Desde

    15 fevereiro 2007
018
Publicações

2022

Pharmacological Targeting of Senescence with ABT-263 in Experimental Heart Failure with Preserved Ejection Fraction

Autores
Silva, E; Tome, I; Vasques Novoa, F; Silva, A; Conceicao, G; Miranda Silva, D; Pitrez, P; Barros, A; Leite Moreira, A; Pinto Do O, P; Santos, S; Pires, IF; Ferreira, L; Nascimento, D;

Publicação
CARDIOVASCULAR RESEARCH

Abstract
Abstract Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Fundação Ciência e Tecnlogia HFpEF is the most common form of heart disease in the elderly and is associated with high morbidity and mortality. Our understanding of HFpEF pathophysiology is limited and development of efficient therapies that alter the clinical course of the disease has proved greatly challenging. Although aging is a risk factor of HFpEF1, the involvement of aging hallmarks such as cell senescent and immunosenescence is unclear. Recently, a link between endothelial senescence and HFpEF development was demonstrated in mice with accelerated aging [1], endorsing anti-aging pharmacologic as potential new therapeutic alternatives for HFpEF. In fact, the senolytic (drugs that selectively promote apoptosis of senescent cells) ABT-263 has already proven efficacy in the context of cardiovascular diseases. Further studies are needed to clarify the relevance of aging and of anti-aging therapies in the context of HFpEF. Using ZSF1 obese rats (ZSF1-Ob) as model of HFpEF we showed from 18 weeks signs of immunosenescence compared to ZSF1-Ln, namely an increased frequency of circulating myeloid cells and decreased frequency of T and B cells. Concomitantly, expression of pro-inflammatory factors (IL-6, IL-1, TGF-ß, TNF-a) was upregulated in peripheral blood mononuclear cells (PBMCs) of ZSF1-Ob which also displayed characteristic features of cell senescence (p21 expression, lysosomal endogenous Beta-galactosidase (SA-B-Gal) senescence-associated secretory phenotype (SASP) and up-regulation of BCL-XL. Importantly, no signs of cellular senescence (SA-B-gal, pH2AX and senescence associated pathways) were found in the main hematopoietic organs (spleen and bone marrow). Alongside, these systemic alterations, an upsurge of cellular senescence was observed in myocardium of ZSF1-Ob rats, particularly in endothelial and hematopoietic cells. Serum of ZSF1-Ob rat was able to induce activation and cellular senescence of cardiac microvascular endothelial cells, indicating that systemic circulating factors may be the upstream mechanism of cellular senescence and dysfunction in HFpEF. Analysis of HFpEF patients and a control cohort adjusted to main co-morbidities further demonstrated accumulation of senescent monocytes in HFpEF patients. In these patients, the senescence marker SA-B-Gal correlated with plasmatic brain natriuretic peptide (BNP) levels and pulmonary artery systolic pressure. Targeting aging hallmarks through the treatment of ZSF1-Ob rat with ABT-263 resulted in a reduction in circulating senescent cells, decreased systemic and local inflammation, re-established immune proportions, restore the levels of circulating BNP and attenuated myocardial remodeling, particularly endothelial dysfunction and fibrosis. Collectively these findings support that premature cellular senescence contributes to the establishment of a deleterious pro-inflammatory environment in HFpEF and that senolytic agents hold promise for the treatment of this syndrome.

2010

Optical recognition of music symbols: A comparative study

Autores
Ana Maria Rebelo; Guilherme Capela; Jaime Santos Cardoso

Publicação
IJDAR - International Journal on Document Analysis and Recognition, vol.13, no.1, pp.19-31

Abstract
Many musical works produced in the past are still currently available only as original manuscripts or as photocopies. The preservation of these works requires their digitalization and transformation into a machine-readable format. However, and despite the many research activities on optical music recognition (OMR), the results for handwritten musical scores are far from ideal. Each of the proposed methods lays the emphasis on different properties and therefore makes it difficult to evaluate the efficiency of a proposed method. We present in this article a comparative study of several recognition algorithms of music symbols. After a review of the most common procedures used in this context, their respective performances are compared using both real and synthetic scores. The database of scores was augmented with replicas of the existing patterns, transformed according to an elastic deformation technique. Such transformations aim to introduce invariances in the prediction with respect to the known variability in the symbols, particularly relevant on handwritten works. The following study and the adopted databases can constitute a reference scheme for any researcher who wants to confront a new OMR algorithm face to well-known ones.

2009

Staff Detection with Stable Paths

Autores
Jaime Santos Cardoso; Artur Capela; Ana Maria Rebelo; Carlos Alberto Guedes; Joaquim Pinto da Costa

Publicação
IEEE TPAMI - IEEE Transactions on Pattern Analysis and Machine Intelligence, vol.31, no.6, pp.1134-1139

Abstract

2008

A Connected Path Approach for Staff Detection on a Music Score

Autores
Jaime Santos Cardoso; Guilherme Artur Capela; Ana Maria Rebelo; Carlos Alberto Guedes

Publicação
ICIP 2008 - 2008 IEEE International Conference on Image Processing, pp.1005-1008, San Diego, USA

Abstract

2008

Integrated Recognition System for Music Scores

Autores
Guilherme Capela; Jaime Santos Cardoso; Ana Maria Rebelo; Carlos Alberto Guedes

Publicação
ICMC2008 - International Computer Music Conference 2008, Belfast, Northern Ireland

Abstract