Abstract
Advances in technology are leading to more and more devices integrating sensors capable of acquiring data quickly and with high accuracy. Point clouds are no exception. Therefore, there is increased research interest in the large amount of available light detection and ranging (LiDAR) data by point cloud classification using artificial intelligence. Nevertheless, point cloud labeling is a time-consuming task. Hence the amount of labeled data is still scarce. Data synthesis is gaining attention as an alternative to increase the volume of classified data. At the same time, the amount of Building Information Models (BIMs) provided by manufacturers on website databases is increasing. In line with these recent trends, this paper presents a deep-learning framework for classifying point cloud objects based on synthetic data sets created from BIM objects. The method starts by transforming BIM objects into point clouds deriving a data set consisting of 21 object classes characterized with various perturbation patterns. Then, the data set is split into four subsets to carry out the evaluation of synthetic data on the implemented flexible two-dimensional (2D) deep neural framework. In the latter, binary or greyscale images can be generated from point clouds by both orthographic or perspective projection to feed the network. Moreover, the surface variation feature was computed in order to aggregate more geometric information to images and to evaluate how it influences the object classification. The overall accuracy is over 85% in all tests when orthographic images are used. Also, the use of greyscale images representing surface variation improves performance in almost all tests although the computation of this feature may not be robust in point clouds with complex geometry or perturbations. (C) 2022 American Society of Civil Engineers.

Abstract
Firms have available many forms of collaboration, including cooperatives or joint ventures, in this way leveraging their market power. Customers, however, are atomic agents with few mechanisms for collaborating, leading to an unbalanced buyer-supplier relationship and economic surpluses that shift to producers. Some group buying websites helped alleviate the problem by offering bulk discounts, but more advancements can be made with the emergence of technologies, such as the blockchain. In this article, we propose a customer-push e-marketplace built on top of Ethereum, where customers can aggregate their proposals, and suppliers try to outcompete each other in reverse auction bids to fulfil the order. Furthermore, smart contracts make it possible to automate many operational activities, such as payment escrows/release upon delivery confirmation, increasing the efficiency along the supply chain. The implementation of this network is expected to improve market efficiency by reducing transaction costs, time delays, and information asymmetry. Furthermore, concepts such as increased bargaining power and economies of scale, and their effects in buyer-supplier relationships, are also explored.

Abstract
Cardiac auscultation is a key screening tool used for cardiovascular evaluation. When used properly, it speeds up treatment and thus improving the patient's life quality. However, the analysis and interpretation of the heart sound signals is subjective and dependent of the physician's experience and domain knowledge. A computer assistant decision (CAD) system that automatically analyse heart sound signals, can not only support physicians in their clinical decisions but also release human resources to other tasks. In this paper, and to the best of our knowledge, for the first time a SMOTE strategy is used to boost a Convolutional Neural Network performance on the detection of murmur waves. Using the SMOTE strategy, a CNN achieved an overall of 88.43%.

Abstract
Bidirectional electric vehicle supply equipment and charging stations (EVSE) offer new business models and can provide services to the electrical grid. The smart grid lab in Vienna gives unique testing possibilities of future smart grids, as different type of electrical equipment can be operated at a reconstructed, well-known distribution grid. In this work the harmonic and supraharmonic emissions of a bidirectional EVSE are measured according to IEC61000-4-7 and IEC61000-4-30 Ed3 standard as well as the high-frequency grid impedance. In addition, the efficiency and the power factor are determined at various operating points. Although THDi at nominal power (10 kW) is very low and the efficiency and power factor is very high, at low power levels the opposite situation arise. Supraharmonic emissions remain stable independent of the charging/discharging power, and both wideband and narrowband emissions occur. The additional capacitance when connecting the EVSE impacts the high-frequency grid impedance substantially and generates resonance points.

Abstract
Manual assessment of fragments during the pro-cessing of pathology specimens is critical to ensure that the material available for slide analysis matches that captured during grossing without losing valuable material during this process. However, this step is still performed manually, resulting in lost time and delays in making the complete case available for evaluation by the pathologist. To overcome this limitation, we developed an autonomous system that can detect and count the number of fragments contained on each slide. We applied and compared two different methods: conventional machine learning methods and deep convolutional network methods. For conventional machine learning methods, we tested a two-stage approach with a supervised classifier followed by unsupervised hierarchical clustering. In addition, Fast R-CNN and YOLOv5, two state-of-the-art deep learning models for detection, were used and compared. All experiments were performed on a dataset comprising 1276 images of colorec-tal biopsy and polypectomy specimens manually labeled for fragment/set detection. The best results were obtained with the YOLOv5 architecture with a map@0.5 of 0.977 for fragment/set detection.

Abstract
Background: Approximately 62% of patients with breast cancer with a pathogenic variant (BRCA1 or BRCA2) undergo primary breast-conserving therapy. Objective: The study aims to develop a personalized risk management decision support tool for carriers of a pathogenic variant (BRCA1 or BRCA2) who underwent breast-conserving therapy for unilateral early-stage breast cancer. Methods: We developed a Bayesian network model of a hypothetical cohort of carriers of BRCA1 or BRCA2 diagnosed with stage I/II unilateral breast cancer and treated with breast-conserving treatment who underwent subsequent second primary cancer risk-reducing strategies. Using event dependencies structured according to expert knowledge and conditional probabilities obtained from published evidence, we predicted the 40-year overall survival rate of different risk-reducing strategies for 144 cohorts of women defined by the type of pathogenic variants (BRCA1 or BRCA2), age at primary breast cancer diagnosis, breast cancer subtype, stage of primary breast cancer, and presence or absence of adjuvant chemotherapy. Results: Absence of adjuvant chemotherapy was the most powerful factor that was linked to a dramatic decline in survival. There was a negligible decline in the mortality in patients with triple-negative breast cancer, who received no chemotherapy and underwent any secondary risk-reducing strategy, compared with surveillance. The potential survival benefit from any risk-reducing strategy was more modest in patients with triple-negative breast cancer who received chemotherapy compared with patients with luminal breast cancer. However, most patients with triple-negative breast cancer in stage I benefited from bilateral risk-reducing mastectomy and risk-reducing salpingo-oophorectomy or just risk-reducing salpingo-oophorectomy. Most patients with luminal stage I/II unilateral breast cancer benefited from bilateral risk-reducing mastectomy and risk-reducing salpingo-oophorectomy. The impact of risk-reducing salpingo-oophorectomy in patients with luminal breast cancer in stage I/II increased with age. Most older patients with the BRCA1 and BRCA2 pathogenic variants in exons 12-24/25 with luminal breast cancer may gain a similar survival benefit from other risk-reducing strategies or surveillance. Conclusions: Our study showed that it is mandatory to consider the complex interplay between the types of BRCA1 and BRCA2 pathogenic variants, age at primary breast cancer diagnosis, breast cancer subtype and stage, and received systemic treatment. As no prospective study results are available at the moment, our simulation model, which will integrate a decision support system in the near future, could facilitate the conversation between the health care provider and patient and help to weigh all the options for risk-reducing strategies leading to a more balanced decision.