Abstract
Background/Objectives: Obstructive sleep apnea (OSA) classification relies on polysomnography (PSG) results. Current guidelines recommend the development of clinical prediction algorithms in screening prior to PSG. A recent intuitive and user-friendly tool (OSABayes), based on a Bayesian network model using six clinical variables, has been proposed to quantify the probability of OSA. Our aims are (1) to validate OSABayes prospectively, (2) to build a smartphone app based on the proposed model, and (3) to evaluate app usability. Methods: We prospectively included adult patients suspected of OSA, without suspicion of other sleep disorders, who underwent level I or III diagnostic PSG. Apnea-hypopnea index (AHI) and OSABayes probabilities were obtained and compared using the area under the ROC curve (AUC [95%CI]) for OSA diagnosis (AHI >= 5/h) and higher severity levels (AHI >= 15/h) prediction. We built the OSABayes app on 'App Inventor 2', and the usability was assessed with a cognitive walkthrough method and a general evaluation. Results: 216 subjects were included in the validation cohort, performing PSG levels I (34%) and III (66%). OSABayes presented an AUC of 83.6% [77.3-90.0%] for OSA diagnosis and 76.3% [69.9-82.7%] for moderate/severe OSA prediction, showing good response for both types of PSG. The OSABayes smartphone application allows one to calculate the probability of having OSA and consult information about OSA and the tool. In the usability evaluation, 96% of the proposed tasks were carried out. Conclusions: These results show the good discrimination power of OSABayes and validate its applicability in identifying patients with a high pre-test probability of OSA. The tool is available as an online form and as a smartphone app, allowing a quick and accessible calculation of OSA probability.

Abstract
The literature on the impact of research output (RO) on economic growth (EG) has been rapidly expanding. However, the single growth processes of technological laggard countries and the mediating roles of human capital (HC) and structural change have been overlooked. Based on cointegration analyses and Granger causality tests over 40 years (1980-2019) for Portugal, five results are worth highlighting: (1) in the short run, RO is critical to promote EG; (2) the long run relation between RO and EG is more complex, being positive and significant in the case of global and research fields that resemble capital goods (Life, Physical, Engineering & Technology, and Social Sciences), and negative in the case of research fields that resemble final goods (Clinical & Pre-Clinical Health, and Arts & Humanities); (3) existence of important short run mismatches between HC and scientific production, with the former mitigating the positive impact of the latter on EG; (4) in the long run, such mismatches are only apparent for 'general' HC (years of schooling of the population 25 + years), with the positive association between RO and EG being enhanced by increases in 'specialized' HC (number of R&D researchers); (5) structural change processes favouring industry amplify the positive (long-run) association and (short-run) impact of RO on EG. Such results robustly suggest that even in technologically laggard contexts, scientific production is critical for economic growth, especially when aligned with changes in sectoral composition that favour industry.

Abstract
Due to the current focus on offshore renewable energies worldwide, more capacity of them is expected in the future. The electrical layout design considerably affects overall implementation cost of these offshore power plants as well as the losses of energy inside the farms. Considering the increasing size of offshore wind farms, it is necessary to develop more robust and computationally efficient methods to design the electrical layout of these farms. In this work, a two-phase approach is proposed for the optimization of the electrical layout of the offshore wind farms; the proposed framework aims at the minimization of the ohmic losses and the cost of the cables. To solve the optimization problem, Simulated Annealing (SA) is applied in this study. A tool is also developed using Python programming language to implement the framework for the optimization of the electrical layout of the offshore farms. The proposed method is then applied to a farm with 100 turbines and an overall rated capacity of 1GW. The results approved the accuracy of the two-phase approach in finding the optimal electrical layout as well as the high efficiency in terms of the computational burden.

Abstract
Memory safety issues in C are the origin of various vulnerabilities that can compromise a program’s correctness or safety from attacks. We propose an approach to tackle memory safety by replicating Rust’s Mid-level Intermediate Representation (MIR) Borrow Checker. Our solution uses static analysis and successive source-to-source code transformations to be composed upstream of the compiler, ensuring maximal compatibility with existing build systems. This allows us to apply the memory safety guarantees of the rustc compiler to C code with fewer changes than a rewrite in Rust. In this work, we present a comprehensive study of Rust’s efforts towards ensuring memory safety, and describe the theoretical basis for a C borrow checker, alongside a proof-of-concept that was developed to demonstrate its potential. We have evaluated the prototype on the CHStone and bzip2 benchmarks. This prototype correctly identified violations of the ownership and aliasing rules, and exposed incompatibilities between such rules and common C patterns, which can be addressed in future work.

Abstract
Cybersickness refers to the negative symptoms caused by exposure to a Virtual Reality (VR) experience. The literature is consensual that cybersickness is a key factor in an experience, as the non-existence of cybersickness provides an optimal virtual experience. Thus, it is of utmost importance to evaluate cybersickness when assessing VR applications to understand the impact of this factor on the user experience and, ultimately, on the VR application viability. However, there is a lack of Portuguese instruments to evaluate this variable. To tackle this, this aimed to translate and validate the Simulator Sickness Questionnaire (SSQ) to Portuguese so it can be used with the Portuguese population and maintain its psychometric properties. The new instrument was validated using a sample of 603 Portuguese subjects aged between 16 and 79. Based on the observed results, the obtained theoretical model shows that the Portuguese version of the SSQ is valid for properly evaluating cybersickness in VR experiences with Portuguese samples.

Abstract
The progressive and complex nature of Parkinson's disease (PD) may largely benefit from regular and personalised monitoring, which is beyond the current clinical practice and routinely available systems. This paper proposes a simple and effective system to address this issue by using a wearable device to quantify a key PD's motor symptom - gait impairment as a proof-of-concept for a future broader approach. In this study, 60 inertial signals were collected from the ankle in 41 PD patients during a clinical standard gait assessment exercise. Each exercise iteration was classified by a specialised neurologist based on the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS). A signal processing and feature extraction pipeline was employed to characterise gait, followed by a statistical analysis of their ability to differentiate between the 5 levels of impairment. The results revealed that 4 of the 8 studied features exhibited high discriminatory power between different severity levels of gait impairment, with statistical significance. The distinguishing capability of these 4 extracted features - gait consistency, rotation angle, mean height and length of steps - holds great promise for the development of a gait severity quantification remote monitoring for PD patients at home or on the move, proving the concept of the usefulness of wearable devices for regular and personalised PD symptom monitoring.