Abstract
Flexibility markets are emerging across Europe to improve the efficiency and reliability of distribution networks. This paper presents a methodology that integrates local flexibility markets into network maintenance scheduling, optimizing the process by contracting flexibility to avoid technical issues under the topology defined to operate the network during maintenance. A meta-heuristic approach, Evolutionary Particle Swarm Optimization (EPSO), is used to determine the optimal network topology.

Abstract

Abstract
Inherited retinal diseases (IRDs) are genetic disorders affecting photoreceptors and the retinal pigment epithelium, leading to progressive vision loss. Retinitis pigmentosa (RP), the most common IRD, manifests as night blindness, peripheral vision loss, and eventually central vision decline. RP is genetically diverse and can be categorized into non-syndromic and syndromic. Advanced imaging technologies such as fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT) facilitate diagnosing and managing these conditions. The integration of artificial intelligence in analyzing retinal images has shown promise in identifying genes associated with RP. This study used a dataset from Portuguese public hospitals, comprising 2798 FAF images labeled for syndromic and non-syndromic RP across 66 genes. Three pre-trained models, Inception-v3, ResNet-50, and VGG-19, were used to classify these images, obtaining an accuracy of over 80% in the training data and 54%, 56%, and 54% in the test data for all models. Data preprocessing included class balancing and boosting to address variability in gene representation. Model performance was evaluated using some main metrics. The findings demonstrate the effectiveness of deep learning in automatically classifying retinal images for different RP-associated genes, marking a significant advancement in the diagnostic capabilities of artificial intelligence and advanced imaging techniques in IRD.

Abstract
The world faces unprecedented challenges related to the so-called Triple Planetary Crisis (climate changes, massive pollution, biodiversity losses). The Linear Economy model of development represents a very relevant cause for these crises effects, since it is anchored on the paradox of ever-growing natural resources extraction within a finite planet space and limited policy barriers for ecosystems degradation. Circular Economy emerges as a promising alternative development model, but it still urges for effective implementation. This work presents a novel De-Production model that combines, by design or redesign, the articulation of R-Strategies and D-Strategies across the product and production life cycles in order to unblock circular business models. It is proposed a systemic approach considering product circularity by means of activating R-Strategies, improving both production operations and de-production operations via value retention mindset. The model is tested via discrete simulation in a remanufacturing case study of a bicycle wheel assembly. © 2025 Elsevier B.V., All rights reserved.

Abstract
Introduction: The importance of investigating innovative technologies to improve patient rehabilitation is fundamental in the current context of healthcare. This highlights the need to map the technological resources used in the rehabilitation of adult burn patients. Methods: A scoping review was conducted according to the parameters set by the Joanna Briggs Institute (JBI) guidelines and structured using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and MetaAnalyses for Scoping Reviews). The scientific literature search covered various databases: Medline, CINAHL, SportDiscus, Psychology & Behavioral Sciences Collection, Scopus, SciELO, and the Cochrane Library. The inclusion criteria considered studies related to the use of technological resources in the rehabilitation of burn patients. The research was conducted until November 2024. Results: A total of 19 articles published between 2000 and 2024 were included. The technological resources analyzed included virtual reality (10 studies), exergames (6 studies), exoskeletons (4 studies), and augmented reality (1 study). These resources primarily aimed to promote motor functionality, increase muscle strength, and enhance joint range of motion. Conclusion: The technologies applied to the rehabilitation of burn patients represent a promising advancement, with the potential to transform the paradigm of rehabilitation, making it more interactive. Future research should focus on a detailed analysis of the long-term benefits and on integrating these technologies into standard rehabilitation protocols.

Abstract
Distributed energy resources (DERs) offer untapped potential to meet the flexibility needs of power systems with a high share of non-dispatchable renewable generation, and local flexibility markets (LFMs) can be effective mechanisms for procuring it. In LFMs, energy communities (ECs) can aggregate and offer flexibility from their members' DERs to other parties. However, since flexibility prices are only known after markets clear, flexibility bidding curves can be used to deal with this price uncertainty. Building on previous work by the authors, this paper employs a two-stage methodology to calculate flexibility bids for an EC participating in an LFM, including not only batteries and photovoltaic panels, but also cross-sector (CS) flexible assets like thermal loads and electric vehicles (EVs) to assess their impact. In Stage 1, the EC manager minimizes the energy bill without flexibility to define its baseline. In Stage 2, it computes the optimal flexibility to be offered for each flexibility price to build the flexibility bidding curve. Case examples allow to assess the impact of CS flexible assets on the final flexibility offered.