2026
Authors
Kurteshi, R; Almeida, F;
Publication
Leading Transdisciplinary Learning Readiness for the Entrepreneurial Workforce
Abstract
2026
Authors
Almeida, J; Cunha, JPS;
Publication
JOURNAL OF NEURAL ENGINEERING
Abstract
Brain connectivity analysis based on stereo-electroencephalography (SEEG) has been increasingly explored as a tool for studying Epileptogenic Networks and supporting therapies for Refractory Epilepsy. In this Review, we summarize recent methodologies and findings on SEEG-based Functional and Effective Connectivity, which aim to define the dependence and influence between spatially distributed neurophysiological events. After briefly outlining the network analysis measurements used to interpret connectivity, we detail the mathematical principles underlying the 11 reviewed connectivity methods, along with the main findings characterizing the epileptogenic network for each method. Based on their principles, these methods can be organized into four classes: Signal Interaction, Signal Synchronization, Causality, and Other Nonlinear methods. Across these methods, consistent network signatures emerge, including functional isolation of the Epileptogenic Zone during interictal periods and complex hypersynchronization dynamics during seizures. As there is no single best method, we present a methodological framework that summarizes the relationship assumptions, computational costs, signal-processing requirements, and clinical use cases for each method. Finally, we discuss current challenges and future trends in this field.
2026
Authors
Rocha, T; Nunes, R; Reis, A; Barroso, J;
Publication
PROCEEDINGS OF 19TH IBERIAN CONFERENCE ON INFORMATION SYSTEMS AND TECHNOLOGIES, CISTI 2024, VOL 1
Abstract
Within the scope of the Mobilizing Agenda for the Development of Intelligent Green Mobility Products and Systems (A-MoVeR), PPS2 defined the presentation of a new electric motorcycle, with high autonomy, aimed at promoting comfortable, efficient and efficient urban mobility. green. In this context, the need to develop interfaces that meet the expectations of end users, promoting user experience and security are crucial. Therefore, following a User-Centered Design (DCU) methodology, a co-design perspective and UX data collection methods, this article presents the steps and preliminary results of the preparation, face-to-face session and subsequent analysis of results of a preliminary moment of acquiring knowledge on how to optimize motorcycle user interfaces. Specifically: script planning, requirements and analysis of user feedback collected through audiovisual recording, in a focus group, are described.
2026
Authors
Giesteira, B; Souza, T; Sousa, A; Rodrigues, L; Maior, GV;
Publication
Reshaping Health Promotion and Disease Prevention Through Digital Innovation
Abstract
2026
Authors
Rocha Gomes, J; Teixeira, AS; Ruiz Romeo, M; Oliveira, JM; Ramos, P;
Publication
Cancers
Abstract
Background: Biliary tract cancers (BTCs), encompassing cholangiocarcinoma and gallbladder carcinoma, are aggressive malignancies with poor prognosis and increasing incidence in selected regions worldwide. Advances in imaging, biomarker profiling, immunotherapy, and targeted therapies have improved treatment options but have also increased the economic pressure on health systems. Understanding the economic evidence on BTC is therefore important for resource allocation and health technology assessment. Methods: We systematically searched PubMed/MEDLINE, Embase, Scopus, and Web of Science for peer-reviewed economic studies of BTC published from January 2010 to March 2025. Eligible studies included cost-effectiveness, cost–utility, cost–benefit, cost-of-illness, and resource-use analyses. The review followed PRISMA reporting principles. Reporting completeness was assessed using CHEERS 2022, and methodological credibility was appraised using the Drummond framework. Results: Twenty studies were included: 13 cost-effectiveness or cost–utility analyses and seven cost-of-illness or resource-use studies. Conventional chemotherapy strategies, including gemcitabine plus cisplatin in some settings and other cytotoxic combinations in selected jurisdictions, generally produced more favorable economic results than newer systemic therapies, although findings varied by country, threshold, comparator, and price assumptions. First-line immunotherapy combinations and biomarker-directed targeted therapies frequently produced ICERs above jurisdiction-specific willingness-to-pay thresholds at current prices, often requiring substantial price reductions to approach cost-effectiveness. Real-world studies showed high resource use and costs, particularly with hospitalizations and later treatment lines. Evidence on screening and prevention was limited, with one study suggesting that ultrasound surveillance may be cost-effective in a liver fluke-endemic region of Thailand. Discussion: The available economic evidence suggests that affordability and jurisdiction-specific value assessment are central to BTC policy decisions. Current prices for several immunotherapy and targeted agents limit cost-effectiveness in published models, while evidence on prevention, early detection, and care-pathway interventions remains sparse and context-specific. © 2026 by the authors.
2026
Authors
Bernardo, H; Bechir, MH;
Publication
eceee Summer Study proceedings
Abstract
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