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There is a growing demand for persistent data in IoT, edge and similar resource-constrained devices. However, standard FLASH memory-based solutions present performance, energy, and reliability limitations in these applications. We propose MRAM persistent memory as an alternative to FLASH based storage. Preliminary experimental results show that its performance, power consumption, and reliability in typical database workloads is competitive for resource-constrained devices. This opens up new opportunities, as well as challenges, for small-scale database systems. MRAM is tested for its raw performance and applicability to key-value and relational database systems on resource-constrained devices. Improvements of as much as three orders of magnitude in write performance for key-value systems were observed in comparison to an alternative NAND FLASH based device. © 2023 Copyright for this paper by its authors. Use permitted under Creative Commons License Attribution 4.0 International (CC BY 4.0).

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This short paper summarizes an article published in the Journal of Automated Reasoning [7]. It presents Pardinus, an extension of the popular Kodkod [12] relational model finder with linear temporal logic (including past operators) to simplify the analysis of dynamic systems. Pardinus includes a SAT-based bounded model checking engine and an SMV-based complete model checking engine, both allowing iteration through the different instances (or counterexamples) of a specification. It also supports a decomposed parallel analysis strategy that improves the efficiency of both analysis engines on commodity multi-core machines.

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Author summaryCancer therapies often fail because tumor cells become resistant to treatment. One way to overcome resistance is by treating patients with a combination of two or more drugs. Some combinations may be more effective than when considering individual drug effects, a phenomenon called drug synergy. Computational drug synergy prediction methods can help to identify new, clinically relevant drug combinations. In this study, we developed several deep learning models for drug synergy prediction. We examined the effect of using different types of deep learning architectures, and different ways of representing drugs and cancer cell lines. We explored the use of biological prior knowledge to select relevant cell line features, and also tested data-driven feature reduction methods. We tested both precomputed drug features and deep learning methods that can directly learn features from raw representations of molecules. We also evaluated whether including genomic features, in addition to gene expression data, improves the predictive performance of the models. Through these experiments, we were able to identify strategies that will help guide the development of new deep learning models for drug synergy prediction in the future. One of the main obstacles to the successful treatment of cancer is the phenomenon of drug resistance. A common strategy to overcome resistance is the use of combination therapies. However, the space of possibilities is huge and efficient search strategies are required. Machine Learning (ML) can be a useful tool for the discovery of novel, clinically relevant anti-cancer drug combinations. In particular, deep learning (DL) has become a popular choice for modeling drug combination effects. Here, we set out to examine the impact of different methodological choices on the performance of multimodal DL-based drug synergy prediction methods, including the use of different input data types, preprocessing steps and model architectures. Focusing on the NCI ALMANAC dataset, we found that feature selection based on prior biological knowledge has a positive impact-limiting gene expression data to cancer or drug response-specific genes improved performance. Drug features appeared to be more predictive of drug response, with a 41% increase in coefficient of determination (R-2) and 26% increase in Spearman correlation relative to a baseline model that used only cell line and drug identifiers. Molecular fingerprint-based drug representations performed slightly better than learned representations-ECFP4 fingerprints increased R-2 by 5.3% and Spearman correlation by 2.8% w.r.t the best learned representations. In general, fully connected feature-encoding subnetworks outperformed other architectures. DL outperformed other ML methods by more than 35% (R-2) and 14% (Spearman). Additionally, an ensemble combining the top DL and ML models improved performance by about 6.5% (R-2) and 4% (Spearman). Using a state-of-the-art interpretability method, we showed that DL models can learn to associate drug and cell line features with drug response in a biologically meaningful way. The strategies explored in this study will help to improve the development of computational methods for the rational design of effective drug combinations for cancer therapy.

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The short-circuit current is one of the most important security operational parameters. With the increased penetration of DERs, it is crucial to frequently and periodically monitor it, ideally every 24 hours and with high granularity (e.g., 30 minutes). This paper develops a short-circuit computation methodology to calculate the complete short-circuit current in the TSO/DSO interface nodes (extra high voltage/high voltage (EHV/HV) substations), which could be used for operational planning purposes, considering the active contributions to the short-circuit current originating from both transmission and distribution networks. A TSO-DSO coordination procedure is presented to obtain the day-ahead short-circuit currents forecast. Moreover, two real cases are provided as examples for validation of the demonstrated procedures. © The Institution of Engineering and Technology 2023.