Abstract
Testing for infection with SARS-CoV-2 is an important intervention in reducing onwards transmission of COVID-19, particularly when combined with the isolation and contact-tracing of positive cases. Many countries with the capacity to do so have made use of lab-processed Polymerase Chain Reaction (PCR) testing targeted at individuals with symptoms and the contacts of confirmed cases. Alternatively, Lateral Flow Tests (LFTs) are able to deliver a result quickly, without lab-processing and at a relatively low cost. Their adoption can support regular mass asymptomatic testing, allowing earlier detection of infection and isolation of infectious individuals. In this paper we extend and apply the agent-based epidemic modelling framework Covasim to explore the impact of regular asymptomatic testing on the peak and total number of infections in an emerging COVID-19 wave. We explore testing with LFTs at different frequency levels within a population with high levels of immunity and with background symptomatic PCR testing, case isolation and contact tracing for testing. The effectiveness of regular asymptomatic testing was compared with ‘lockdown’ interventions seeking to reduce the number of non-household contacts across the whole population through measures such as mandating working from home and restrictions on gatherings. Since regular asymptomatic testing requires only those with a positive result to reduce contact, while lockdown measures require the whole population to reduce contact, any policy decision that seeks to trade off harms from infection against other harms will not automatically favour one over the other. Our results demonstrate that, where such a trade off is being made, at moderate rates of early exponential growth regular asymptomatic testing has the potential to achieve significant infection control without the wider harms associated with additional lockdown measures.

Abstract
Catharanthus roseus leaves produce a range of monoterpenoid indole alkaloids (MIAs) that include low levels of the anticancer drugs vinblastine and vincristine. The MIA pathway displays a complex architecture spanning different subcellular and cell-type localizations and is under complex regulation. As a result, the development of strategies to increase the levels of the anticancer MIAs has remained elusive. The pathway involves mesophyll specialised idioblasts where the late unsolved biosynthetic steps are thought to occur. Here, protoplasts of C. roseus leaf idioblasts were isolated by fluorescence-activated cell sorting, and their differential alkaloid and transcriptomic profiles were characterised. This involved the assembly of an improved C. roseus transcriptome from short- and long-read data, IDIO+. It was observed that C. roseus mesophyll idioblasts possess a distinctive transcriptomic profile associated with protection against biotic and abiotic stresses, and indicative that this cell type is a carbon sink, in contrast with surrounding mesophyll cells. Moreover, it is shown that idioblasts are a hotspot of alkaloid accumulation, suggesting that their transcriptome may hold the keys to the in-depth understanding of the MIA pathway and the success of strategies leading to higher levels of the anticancer drugs.

Abstract
Digital twins have been emerging as a hybrid approach that combines the benefits of simulators with the realism of experimental testbeds. The accurate and repeatable set-ups replicating the dynamic conditions of physical environments, enable digital twins of wireless networks to be used to evaluate the performance of next-generation networks. In this paper, we propose the Position-based Machine Learning Propagation Loss Model (P-MLPL), enabling the creation of fast and more precise digital twins of wireless networks in ns-3. Based on network traces collected in an experimental testbed, the P-MLPL model estimates the propagation loss suffered by packets exchanged between a transmitter and a receiver, considering the absolute node's positions and the traffic direction. The P-MLPL model is validated with a test suite. The results show that the P-MLPL model can predict the propagation loss with a median error of 2.5 dB, which corresponds to 0.5x the error of existing models in ns-3. Moreover, ns-3 simulations with the P-MLPL model estimated the throughput with an error up to 2.5 Mbit/s, when compared to the real values measured in the testbed.

Abstract
Predictive Maintenance applications are increasingly complex, with interactions between many components. Black-box models are popular approaches due to their predictive accuracy and are based on deep-learning techniques. This paper presents an architecture that uses an online rule learning algorithm to explain when the black-box model predicts rare events. The system can present global explanations that model the black-box model and local explanations that describe why the black-box model predicts a failure. We evaluate the proposed system using four real-world public transport data sets, presenting illustrative examples of explanations.

Abstract
This paper investigates voltage regulation in low voltage (LV) networks under different loading conditions of a supply network, with increased levels of distributed generation, and in particular with a diverse range of locational solar photovoltaic (PV) penetration. This topic has been researched extensively, with beneficial impacts expected up to a certain point when reverse power flows begin to negatively impact customers connected to the distribution system. In this paper, a voltage-based approach that utilizes novel voltage-based reliability indices is proposed to analyse the risk and reliability of the LV supply feeder, as well as its PV hosting capacity. The proposed indices are directly comparable to results from a probabilistic reliability assessment. The operation of the network is simulated for different PV scenarios to investigate the impacts of increased PV penetration, the location of PV on the feeder, and loading conditions of the MV supply network on the reliability results. It can be seen that all reliability indices improve with increased PV penetration levels when the supply network is heavily loaded and conversely deteriorate when the supply network is lightly loaded. Moreover, bus voltages improve when an on-load tap changer is fitted at the secondary trans-former which leads to better reliability performance as the occurrence and duration of low voltage violations are reduced in all PV scenarios. The approach in this paper is opposed to the conventional reliability assessment, which considers sustained interruptions to customers caused by failure of network components, and thus contributes to a comprehensive analysis of quality of service by considering transient events (i.e., voltage related) in the LV distribution network.

Abstract
Artificial intelligence (AI) brings great potential but also risks to the electricity industry. Following the EU's current regulatory proposal, the EU Regulation for Artificial Intelligence (AI Act), there will be direct, potentially adverse effects on companies of the electricity industry in Europe and beyond, as well as those active in the development of AI systems. In this paper, we develop a replicable framework for estimating compliance costs for different electricity market agents that will need to comply with the numerous requirements the AI Act imposes. The electricity systems of Austria, Greece and Switzerland are used as case-studies. We estimate annual, aggregated costs for electricity market agents ranging from less than one million to almost 200 million Euros per country, depending on compliance costs scenarios. Results suggest that a profit growth of 10% through AI utilization is needed to offset the highest added compliance cost of the AI Act on electricity market agents. Eventually, we further show how to assess the regional differences of these costs added to system operation, providing spatially disaggregated compliance costs estimates that consider the structural differences of the electricity industry within 26 Swiss cantons.