Abstract
Bipolar Disorder (BD) is a chronic and severe psychiatric illness presenting with mood alterations, including manic, hypomanic, and depressive episodes. Due to the high clinical heterogeneity and lack of biological validation, both treatment and diagnosis of BD remain problematic and challenging. In this context, this paper proposes a novel intelligent system applied to the diagnosis of BD. First, each patient’s single nucleotide polymorphism (SNP) data is represented by QR codes, which reduces the high dimensionality of the problem and homogenizes the data representation. For the initial tests of the system, the Wellcome Trust Case Control Consortium (WTCCC) dataset was used. The preliminary results are encouraging, with an AUC value of 0.82 and an accuracy of 82%, correctly classifying all cases and most controls. This approach reduces the dimensionality of large amounts of data and can help improve diagnosis and deliver the right treatment to the patient. Furthermore, the architecture of the system is versatile and could be adapted and used to diagnose other diseases where there is also high dimensionality. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

Abstract
Enhancing the reproducibility and comprehension of adaptive immune receptor repertoire sequencing (AIRR-seq) data analysis is critical for scientific progress. This study presents guidelines for reproducible AIRR-seq data analysis, and a collection of ready-to-use pipelines with comprehensive documentation. To this end, ten common pipelines were implemented using ViaFoundry, a user-friendly interface for pipeline management and automation. This is accompanied by versioned containers, documentation and archiving capabilities. The automation of pre-processing analysis steps and the ability to modify pipeline parameters according to specific research needs are emphasized. AIRR-seq data analysis is highly sensitive to varying parameters and setups; using the guidelines presented here, the ability to reproduce previously published results is demonstrated. This work promotes transparency, reproducibility, and collaboration in AIRR-seq data analysis, serving as a model for handling and documenting bioinformatics pipelines in other research domains.

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In recent years, the number of crimes with weapons has grown on a large scale worldwide, mainly in locations where enforcement is lacking or possessing weapons is legal. It is necessary to combat this type of criminal activity to identify criminal behavior early and allow police and law enforcement agencies immediate action.Despite the human visual structure being highly evolved and able to process images quickly and accurately if an individual watches something very similar for a long time, there is a possibility of slowness and lack of attention. In addition, large surveillance systems with numerous equipment require a surveillance team, which increases the cost of operation. There are several solutions for automatic weapon detection based on computer vision; however, these have limited performance in challenging contexts.A systematic review of the current literature on deep learning-based weapon detection was conducted to identify the methods used, the main characteristics of the existing datasets, and the main problems in the area of automatic weapon detection. The most used models were the Faster R-CNN and the YOLO architecture. The use of realistic images and synthetic data showed improved performance. Several challenges were identified in weapon detection, such as poor lighting conditions and the difficulty of small weapon detection, the last being the most prominent. Finally, some future directions are outlined with a special focus on small weapon detection.

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