Abstract
Counting the occurrences of small subgraphs in large networks is a fundamental graph mining metric with several possible applications. Computing frequencies of those subgraphs is also known as the subgraph census problem, which is a computationally hard task. In this paper we provide a parallel multicore algorithm for this purpose. At its core we use FaSE, an efficient network-centric sequential subgraph census algorithm, which is able to substantially decrease the number of isomorphism tests needed when compared to past approaches. We use one thread per core and employ a dynamic load balancing scheme capable of dealing with the highly unbalanced search tree induced by FaSE and effectively redistributing work during execution. We assessed the scalability of our algorithm on a varied set of representative networks and achieved near linear speedup up to 32 cores while obtaining a high efficiency for the total 64 cores of our machine.

Abstract
This paper presents a planar antenna using low temperature co-fired ceramics (LTCC) substrate for extreme environment applications. An ultra wideband (UWB) elliptical patch antenna was designed and fabricated using an LTCC Ceramtec GC substrate to demonstrate the capabilities of the technology for wideband applications. The simulated results were further validated experimentally. The fabricated antenna provides a peak gain of 5dB over a bandwidth of 4 GHz (3 GHz 7 GHz) with return loss better than -10dB. The radiation pattern is omni-directional in the horizontal plane (theta=90 degrees) over the whole frequency range.

Abstract
Chimeric RNAs originating from two or more different genes are known to exist not only in cancer, but also in normal tissues, where they can play a role in human evolution. However, the exact mechanism of their formation is unknown. Here, we use RNA sequencing data from 462 healthy individuals representing 5 human populations to systematically identify and in depth characterize 81 RNA tandem chimeric transcripts, 13 of which are novel. We observe that 6 out of these 81 chimeras have been regarded as cancer-specific. Moreover, we show that a prevalence of long introns at the fusion breakpoint is associated with the chimeric transcripts formation. We also find that tandem RNA chimeras have lower abundances as compared to their partner genes. Finally, by combining our results with genomic data from the same individuals we uncover intronic genetic variants associated with the chimeric RNA formation. Taken together our findings provide an important insight into the chimeric transcripts formation and open new avenues of research into the role of intronic genetic variants in post-transcriptional processing events. © 2014 Greger et al.

Abstract
This work addresses the problem of mining data streams generated in dynamic environments where the distribution underlying the observations may change over time. We present a system that monitors the evolution of the learning process. The system is able to self-diagnose degradations of this process, using change detection mechanisms, and self-repair the decision models. The system uses meta-learning techniques that characterize the domain of applicability of previously learned models. The meta-learner can detect recurrence of contexts, using unlabeled examples, and take pro-active actions by activating previously learned models. The experimental evaluation on three text mining problems demonstrates the main advantages of the proposed system: it provides information about the recurrence of concepts and rapidly adapts decision models when drift occurs.

Abstract
Providing quality public transportation can be extremely expensive when demand is low, variable and unpredictable. Demand Responsive Transportation (DRT) systems try to address these issues with routes and frequencies that may vary according to observed demand. The design and operation of DRTs involve multiple criteria and have a combinatorial nature that prevents the use of traditional optimization methods. We have developed an innovative Decision Support System (DSS) integrating simulation and optimization, to help design and operate DRT services, minimizing operating costs and maximizing the service quality. Experiments inspired in real problems have shown the potential of this DSS. © Springer International Publishing Switzerland 2014.

Abstract
Identification of genetic variants affecting splicing in RNA sequencing population studies is still in its infancy. Splicing phenotype is more complex than gene expression and ought to be treated as a multivariate phenotype to be recapitulated completely. Here we represent the splicing pattern of a gene as the distribution of the relative abundances of a geneâ(tm) s alternative transcript isoforms. We develop a statistical framework that uses a distance-based approach to compute the variability of splicing ratios across observations, and a non-parametric analogue to multivariate analysis of variance. We implement this approach in the R package sQTLseekeR and use it to analyze RNA-Seq data from the Geuvadis project in 465 individuals. We identify hundreds of single nucleotide polymorphisms (SNPs) as splicing QTLs (sQTLs), including some falling in genome-wide association study SNPs. By developing the appropriate metrics, we show that sQTLseekeR compares favorably with existing methods that rely on univariate approaches, predicting variants that behave as expected from mutations affecting splicing. © 2014 Macmillan Publishers Limited.