Abstract
As more distributed energy resources become part of the demand-side infrastructure, quantifying their energy flexibility on a community scale is crucial. CityLearn v1 provided an environment for benchmarking control algorithms. However, there is no standardized environment utilizing realistic building-stock datasets for distributed energy resource control benchmarking without co-simulation or third-party frameworks. CityLearn v2 extends CityLearn v1 by providing a stand-alone simulation environment that leverages the End-Use Load Profiles for the U.S. Building Stock dataset to create grid-interactive communities for resilient, multi-agent, and objective control of distributed energy resources with dynamic occupant feedback. While the v1 environment used pre-simulated building thermal loads, the v2 environment uses data-driven thermal dynamics and eliminates the need for co-simulation with building energy performance software. This work details the v2 environment and provides application examples that use reinforcement learning control to manage battery energy storage system, vehicle-to-grid control, and thermal comfort during heat pump power modulation.

Abstract
Abstract Background. Breast cancer treatment has improved overall survival rates, with different locoregional approaches offering patients similar locoregional control but variable aesthetic outcomes that may lead to disappointment and poor quality of life (QoL). There are no standardized methods for informing patients of the different therapies prior to intervention, nor validated tools for evaluation of aesthetics and patients' expectations. The CINDERELLA Project is based on years of research and developments of new healthcare technologies by various partners, aimed to provide an artificial intelligence (AI) tool to aid shared decision-making by showing breast cancer patients the predicted aesthetic outcomes of their locoregional treatment. The clinical trial will evaluate the use of this tool within an AI cloud-based platform approach (CINDERELLA App) versus a standard approach. We anticipate that the CINDERELLA App will lead to improved satisfaction, psychosocial well-being and health-related QoL while maintaining the quality of care and providing environmental and economic benefits. Trial design. CINDERELLA is an international multicentric interventional randomized controlled open-label clinical trial. Using the CINDERELLA App, the AI and Digital Health arm will provide patients with complete information about the proposed types of locoregional treatments and photographs of similar patients previously treated with the same techniques. The Control arm will follow the standard approach of each clinical site. Randomization will be conducted online using the digital health platform CANKADO, ensuring a balanced distribution of participants between the two groups. CANKADO is the underlying platform through which physicians control the patients' app content and conduct all data collection. Privacy, data protection and ethical principles in AI usage were taken into account. Eligibility criteria. Patients diagnosed with primary breast cancer without evidence of systemic disease. All patients must sign an informed consent and be able to use a web-based app autonomously or with home-based support. Specific aims. Primary objective: to assess the levels of agreement among patients' expectations regarding the aesthetic outcome before and 12 months after locoregional treatment. The trial will also evaluate the aesthetic outcome level of agreement between the AI evaluation tool and self-evaluation. Secondary objectives: health-related QoL (EQ-5D-5L and BREAST-Q ICHOM questionnaires) and resource consumption (e.g., time spent in the hospital, out-of-pocket expenses). The questionnaires and photographs will be applied prior to any treatment, at wound healing, at 6 and 12 months following the completion of locoregional therapy. Statistical methods. Wilcoxon signed rank test will be used to assess the intervention's impact on the agreement level between expectations and obtained results. Weighted Cohen's kappa will be calculated to measure the improvement in classifying aesthetic results with intervention. Statistical tests and/or bootstrap techniques will compare results between arms. A similarity measure will be calculated between self-evaluation and outcome obtained with the AI tool for each participant, and a beta regression model will be used to analyze the intervention's effect. Secondary objectives will be evaluated by scoring questionnaires based on provided guidelines. Target accrual. The clinical trial, led by Champalimaud Clinical Centre, will enroll a minimum of 515 patients in each arm between July 2023 and January 2025. Recruitment is currently open at five study sites in Germany, Israel, Italy, Poland and Portugal. The clinical trial is still open for further international study sites. Funding. European Union grant HORIZON-HLTH-2021-DISEASE-04-04 Agreement No. 101057389. Citation Format: Eduard-Alexandru Bonci, Orit Kaidar-Person, Marília Antunes, Oriana Ciani, Helena Cruz, Rosa Di Micco, Oreste Davide Gentilini, Nicole Rotmensz, Pedro Gouveia, Jörg Heil, Pawel Kabata, Nuno Freitas, Tiago Gonçalves, Miguel Romariz, Helena Montenegro, Hélder P. Oliveira, Jaime S. Cardoso, Henrique Martins, Daniela Lopes, Marta Martinho, Ludovica Borsoi, Elisabetta Listorti, Carlos Mavioso, Martin Mika, André Pfob, Timo Schinköthe, Giovani Silva, Maria-Joao Cardoso. CINDERELLA Clinical Trial (NCT05196269): using artificial intelligence-driven healthcare to enhance breast cancer locoregional treatment decisions [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-19-11.

Abstract
VR (Virtual Reality) is a technology that has been gaining more and more traction over the years, with a market that keeps on increasing in size and great opportunities. This research aims to obtain a better grasp on how VR will impact the future of omnichannel marketing, with a focus on retail. Some businesses have already begun taking advantage of these technologies. They coordinate the integration of both physical and digital channels used to interact with customers in order to improve the customer experience. VR is one such channel, and it offers consumers a whole new way to do their shopping. As technology evolves, it is important that businesses and people stay informed in order to adapt to an ever-changing market. VR is an innovative technology that a lot of potential companies could take advantage of and even gain a competitive advantage over other businesses. Through VR people and businesses are able to access the metaverse. The metaverse is a digital world parallel to our own where customers can interact with brands and their virtual products. By interacting with a virtual version of a product, consumers will have a better grasp of the product they are interested in and make better decisions when purchasing the real one. This not only raises consumer satisfaction but could also be very useful. To fully grasp what VR is capable of, a literature review was performed to understand what VR is in fact and how the metaverse can be used. Finally, a Prisma systematic review will be presented with the research question “How VR will impact the future of omnichannel marketing?”. This was done in order to obtain unbiased data from which conclusions can be drawn. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.

Abstract
Industry 4.0 has brought innovative concepts and technologies that have greatly improved the development of more intelligent, flexible and reconfigurable systems. Two of these concepts, Cyber-Physical Systems (CPSs) and Digital Twins (DTs), have gained significant attention from various stakeholders, e.g., researchers, industry practitioners, and governmental organizations. Both are vital to support the digitalisation of products, machines, and systems, and they focus on the integration of physical and cyber processes, where one affects the other through feedback loops. Having this in mind, this paper aims to better understand how CPS and DT are correlated, particularly exploring their similarities and differences, their positioning within the Industry 4.0 paradigm, and their convergence to develop Industry 4.0 solutions. Some research challenges to develop Industry 4.0 solutions by integrating these concepts are also discussed.

Abstract
This article aimed to analyse state-of-the-art empirical evidence of randomized controlled trials designed to assess preventive cognitive training interventions based on virtual reality for older adults without cognitive impairment, by identifying virtual reality setups and tasks, clinical outcomes and respective measurement instruments, and positive effects on outcome parameters. A systematic electronic search was performed, and six randomized controlled trials were included in the systematic review. In terms of results, the included studies pointed to significant positive impact of virtual reality-based cognitive training interventions on global cognition, memory, attention, information processing speed, walking variability, balance, muscle strength, and falls. However, further research is required to evaluate the adequacy of the virtual reality setups and tasks, to study the impact of the interventions’ duration and intensity, to understand how to tailor the interventions to the characteristics and needs of the individuals, and to compare face-to-face to remote interventions. © 2024 by SCITEPRESS – Science and Technology Publications, Lda.

Abstract
The power transformer is one of the key components of any electrical grid, and, as such, modern day industrialization activities require constant usage of the asset. This increases the possibility of failures and can potentially diminish the lifespan of a power transformer. Dissolved gas analysis (DGA) is a technique developed to quantify the existence of hydrocarbon gases in the content of the power transformer oil, which in turn can indicate the presence of faults. Since this process requires different chemical analysis for each type of gas, the overall cost of the operation increases with number of gases. Thus said, a machine learning methodology was defined to meet two simultaneous objectives, identify gas subsets, and predict the remaining gases, thus restoring them. Two subsets of equal or smaller size to those used by traditional methods (Duval's triangle, Roger's ratio, IEC table) were identified, while showing potentially superior performance. The models restored the discarded gases, and the restored set was compared with the original set in a variety of validation tasks.