Abstract
In this work, a method based on the use of explainable artificial intelligence techniques with multiscale and multidimensional fractal techniques is presented in order to investigate histological images stained with Hematoxylin-Eosin. The CNN GoogLeNet neural activation patterns were explored, obtained from the gradient-weighted class activation mapping and locally-interpretable model-agnostic explanation techniques. The feature vectors were generated with multiscale and multidimensional fractal techniques, specifically fractal dimension, lacunarity and percolation. The features were evaluated by ranking each entry, using the ReliefF algorithm. The discriminative power of each solution was defined via classifiers with different heuristics. The best results were obtained from LIME, with a significant increase in accuracy and AUC rates when compared to those provided by GoogLeNet. The details presented here can contribute to the development of models aimed at the classification of histological images.

Abstract
In this paper, a hybridization method based on Arithmetic optimization algorithm (AOA) and Aquila optimizer (AO) solver namely, the AO-AOA is applied to solve the Optimal Power Flow (OPF) problem to independently optimize generation fuel cost, power loss, emission, voltage deviation, and L index. The proposed AO-AOA algorithm follows two strategies to find a better optimal solution. The first strategy is to introduce an energy parameter (E) to balance the transition between the individuals' procedure of exploration and exploitation in AOAOA swarms. Next, a piecewise linear map is employed to reduce the energy parameter's (E) randomness. To evaluate the performance of the proposed AO-AOA algorithm, it is tested on two well-known power systems i.e., IEEE 30-bus test network, and IEEE 118-bus test system. Moreover, to validate the effectiveness of the proposed (AO-AOA), it is compared with a famous optimization technique as a competitor i.e., Teaching-learning-based optimization (TLBO), and recently published works on solving OPF problems. Furthermore, a robustness analysis was executed to determine the reliability of the AO-AOA solver. The obtained result confirms that not only the AO-AOA is efficient in optimization with significant convergence speed, but also denotes the dominance and potential of the AO-AOA in comparison with other works.

Abstract
Additive manufacturing (AM), broadly known as 3D printing, is transforming how products are designed, produced, and serviced in public health. Recent advances on 3D printing in healthcare have led to lighter, stronger and safer products, reduced lead times and lower costs. However, literature refers that knowledge remains one of the greatest barriers to AM's wider adoption. So, how we leverage the potential of AM to drive innovation is a mandatory topic in science/technology curriculum. Our goal was to develop and implement an educational scenario regarding 3D printing that uses project-based learning to address these topics, strengthening the capacity of students in low secondary level and their schools to promote STEM learning with a focus on public health issues. The scenario supports 9th grade science and ICT teachers in exploring 3D printings and environments using updated scientific/technical evidence. Overall, three schools took part in the study and 202 students participated in the educational scenario. The learning experience supports youths in understanding and reaching high-level comprehension on how STEM may contribute to address these issues, contributing to evidence-based personal decision-making, and public policy. We believe it is relevant to understand if students and schools, when challenged, take a role in their community preparedness for major health problems. By implementing an educational scenario with a focus on 3D printing, and thus potentiate the use of this technology, we intend to help raise awareness on the public health theme.

Abstract
The integration of Distributed Energy Resources (DER) imposes challenges to the operation of distribution networks. This paper conducts a systematic assessment of the impact of DER on distribution network overcurrent protection, considering the behavior of Inverter Based Resources (IBR) during faults in the coordination of medium voltage (MV) feeders' overcurrent protection. Through a detailed analysis of various scenarios, we propose adaptive protection solutions that enhance the reliability and resilience of distribution networks in the face of growing renewable energy integration. Results highlight the advantages of using adaptive protection over traditional methods and topology changes, and delve into current protection strategies, identifying limitations and proposing mitigation strategies. © The Institution of Engineering & Technology 2024.

Abstract
The Deep Brain Stimulation of the Anterior Nucleus of the Thalamus (ANT-DBS) is an effective treatment for refractory epilepsy. In order to assess the involvement of the ANT during voluntary hand repetitive movements similar to some seizure-induced ones, we simultaneously collected videoelectroencephalogram ( vEEG) and ANT-Local Field Potential (LFPs) signals from two epilepsy patients implanted with the PerceptTM PC neurostimulator, who stayed at an Epilepsy Monitoring Unit (EMU) for a 5 day period. For this purpose, a repetitive voluntary movement execution protocol was designed and an event-related desynchronisation/synchronisation (ERD/ERS) analysis was performed. We found a power increase in alpha and theta frequency bands during movement execution for both patients. The same pattern was not found when patients were at rest. Furthermore, a similar increase of relative power was found in LFPs from other neighboring basal ganglia. This suggests that the ERS pattern may be associated to upper limb automatisms, indicating that the ANT and other basal ganglia may be involved in the execution of these repetitive movements. These findings may open a new window for the study of seizure-induced movements (semiology) as biomarkers of the beginning of seizures, which can be helpful for the future of adaptive DBS techniques for better control of epileptic seizures of these patients.

Abstract
The incidence of colorectal cancer (CRC), one of the deadliest cancers around the world, is increasing. Tissue microenvironment (TME) features such as tumor-infiltrating lymphocytes (TILs) can have a crucial impact on diagnosis or decision-making for treating patients with CRC. While clinical studies showed that TILs improve the host immune response, leading to a better prognosis, inter-observer agreement for quantifying TILs is not perfect. Incorporating machine learning (ML) based applications in clinical routine may promote diagnosis reliability. Recently, ML has shown potential for making progress in routine clinical procedures. We aim to systematically review the TILs analysis based on ML in CRC histological images. Deep learning (DL) and non-DL techniques can aid pathologists in identifying TILs, and automated TILs are associated with patient outcomes. However, a large multi-institutional CRC dataset with a diverse and multi-ethnic population is necessary to generalize ML methods. © 2024 Elsevier Ltd