Abstract
Inventory management can be considered as one of the main components of planning and production control. In the literature numerous mathematical models are presented for inventory management, which approach different aspects related to this management. The development of efficient inventory models and the adoption of appropriate optimization methods for solving these models are needed to support in making decisions to inventory management. In this paper, we propose an inventory model that works with multiple products and multiple resource constraints, deciding between the continuous review and periodic review systems. This model is formulated as a nonlinear mixed integer optimization problem. It explores for the resolution of this model, an approach based on Branch-And-Bound method and interior point method. In order to propose this model and choose the method for its resolution, initially an investigation in the literature review on the topic is done. Then, the concept of continuous review and periodic review systems is explored. Finally, two computational tests are proposed, one to compare the results of proposed nonlinear model with the linear model and the other to verify its efficiency and applicability. The results show the potential of the model and solution method used to work with inventory system.

Abstract
In this paper, typical strengths, fault levels, and source impedances are thoroughly analyzed and calculated for the study of quality of supply in 230/400 V 50 Hz distribution systems. Considering all the disparity in distribution network design, this study is based on a comprehensive database containing typical arrangements and equipment in U.K./European systems, as well as on fully documented generic network models supplying four residential load subsectors in the U.K., i.e., from metropolitan to rural areas. Thus, this paper proposes an alternative method for determining reference values of network supply impedances and short-circuit fault levels at different points and locations of the medium-to-low voltage distribution system. The aim of this study is to provide a wider range of benchmark values than those stipulated in the IEC 60725 Standard, which only defines a single-reference threshold of public supply impedances for all types of distribution systems and residential customers. In order to assist network operators in the planning and design of their distribution systems, these values are further disaggregated and classified in this paper according to network/demand type.

Abstract
For a company it is important to improve resource and eco-efficiency in order to save money, the environment and to improve the company's image. We present a new approach combining Multi-layer Stream Mapping (MSM) and a Business Process Based Monitoring and Control Framework to monitor relevant process variables and use the values as an input for MSM to reduce waste and costs. This combination supports the decision making process and allows to identify major inefficiencies and provides means for more sustainability.

Abstract
This paper develops a sustainable approach in the productive context associated with the fish industry. The supply network design problem is addressed by using mathematical programming in order to avail the best configuration for the productive system. In this study, some environmental constraints for each echelon have been presented. Two mathematical models are proposed: cost and profit model. The models are validated with actual data obtained from a Colombian fish industry. The obtained results indicate an improved performance of the new supply network design by considering the sustainability approach derived from sustainable supply chain management (SSCM).

Abstract
AbstractUsing a dataset of somatic Structural Variants (SVs) in cancers from 2658 patients—1220 with corresponding gene expression data—we identified hundreds of genes for which the nearby presence (within 100kb) of an SV breakpoint was associated with altered expression. For the vast majority of these genes, expression was increased rather than decreased with corresponding SV event. Well-known up-regulated cancer-associated genes impacted by this phenomenon included TERT, MDM2, CDK4, ERBB2, CD274, PDCD1LG2, and IGF2. SVs upstream of TERT involved ~3% of cancer cases and were most frequent in liver-biliary, melanoma, sarcoma, stomach, and kidney cancers. SVs associated with up-regulation of PD1 and PDL1 genes involved ~1% of non-amplified cases. For many genes, SVs were significantly associated with either increased numbers or greater proximity of enhancer regulatory elements near the gene. DNA methylation near the gene promoter was often increased with nearby SV breakpoint, which may involve inactivation of repressor elements.AbbreviationsPCAWGthe Pan-Cancer Analysis of Whole Genomes projectSVStructural Variant

Abstract
Demand response (DR) implementations have recently found wide application areas in the context of smart grids. The effectiveness of these implementations is primarily based on the willingness of end-users to be involved in such programs. In this paper, an interactive and user-friendly interface is presented in order to facilitate and accordingly to increase the participation of end-users in DR programs. The proposed interface has the capability of providing the targeted information about the DR events to end-users and system operators, as well as allowing end-users to interactively monitor and control the progress of their appliances. In addition to its benefits to system operators and thus to the improved operation of power systems, the proposed interface particularly aims to exploit the potential energy-related cost savings by providing the required information and resources to end-users via mobile phone. A separate interface apart from the mentioned end-user oriented interface has also been developed for the system operator to more effectively check the status of DR applications in detail. The capabilities of the proposed concept are evaluated in a real smart home in terms of various aspects.