Abstract
Cyber-physical systems (CPS) are a new generation of systems that integrate computation and physical processes interacting with humans in different ways. Integrated networks of computers, sensors and similar technologies monitor and control the physical processes, reporting relevant data to planners and decision-makers, and vice versa. By means of case research, this paper analyzes the implementation of cyber-physical systems aiming at lead-time reduction in two manufacturing contexts, namely footwear and natural cork stoppers. The results of this research contribute to literature and practice with a conceptual framework for the implementation of cyber-physical systems and the discussion of the challenges of implementing this technology.

Abstract
Sign Language Recognition (SLR) has becoming one of the most important research areas in the field of human computer interaction. SLR systems are meant to automatically translate sign language into text or speech, in order to reduce the communicational gap between deaf and hearing people. The aim of this paper is to exploit multimodal learning techniques for an accurate SLR, making use of data provided by Kinect and Leap Motion. In this regard, single-modality approaches as well as different multimodal methods, mainly based on convolutional neural networks, are proposed. Experimental results demonstrate that multimodal learning yields an overall improvement in the sign recognition performance.

Abstract
Creating a mobile urban tourism storytelling application presents several interactivity challenges on how to convey an engaging multimedia experience on-site. This article describes a methodology for fast prototyping of a multimedia mobile applications dedicated to urban tourism storytelling. The application can be a game that takes advantage of several locationbased technologies, freely available geo-referenced media, and augmented reality for immersive gameplay. The goal is to create serious games for tourism that follow a main narrative but where the story can automatically adapt itself to the current location of the player, assimilate possible detours and allow posterior out-of-location playback. Adaptable stories can use dynamic information from map sources such as points of interest (POI), elevation or virtual buildings. The main focus is for these locationbased storytelling games to create more engagement between the tourists and the urban environment. To explore this concept, an application was designed for the city of Porto: Unlocking Porto. This location-based game with a central, yet adaptable, story engages the player into the main sights following an augmented reality path while playing small games. The article discusses and presents solutions for media acquisition, interactive storytelling, game-design interface and multi-disciplinary coordination for mobile app development.

Abstract

Abstract
Background/Aim: This study aimed to evaluate the in vitro efficacy of carboplatin and piroxicam, both in isolation and combined, against T24 and 5637 human urinary bladder cancer cell lines. Materials and Methods: Cell viability, drug interaction, cell morphology, cell proliferation, apoptosis and autophagy were analyzed after 72 h of drug exposure. Statistical analysis was performed and values of p<0.05 were considered statistically significant. Results: Drug exposure in combination led to a significant reduction of cell viability comparatively to single-drug exposure. These combinations resulted in a synergistic interaction in the T24 (combination index for 50% effect (CI50)=0.65) and 5637 (CI50=0.17) cell lines. Notable increase of morphological alterations, a marked decrease of Ki-67 expression, a considerable enhancement of autophagic vacuoles and a minimal effect on apoptosis was observed in both cell lines treated with combined drugs. Conclusion: Data showed that in vitro combination of carboplatin and piroxicam produced a more potent antiproliferative effect when compared to single drugs.

Abstract
An unidirectional single-phase three-wire rectifier is proposed in this paper. Such topology is composed of a noncontrolled leg, two controlled legs, and a capacitor bank. A suitable model, pulse-width modulation, and control strategies of the system are proposed as well. The control strategy includes the synchronization method, in which it imposes the grid currents with the same phase angle of the voltages generated by the rectifier. This method ensures sinusoidal grid currents and mitigates the zero-crossover distortions normally caused by the use of diodes. A comprehensive comparison with two conventional configurations is also presented in this paper. Simulation and experimental results are also presented for validation purposes.