Abstract
The development of a three-dimensional (3D) planing tool for breast cancer surgery requires the existence of proper deformable models of the breast, with parameters that can be manipulated to obtain the desired shape. However, modelling breast is a challenging task due to the lack of physical landmarks that remain unchanged after deformation. In this paper, the fitting of a 3D point cloud of the breast to a parametric model suitable for surgery planning is investigated. Regression techniques were used to learn breast deformation functions from exemplar data, resulting in comprehensive models easy to manipulate by surgeons. New breast shapes are modelled by varying the type and degree of deformation of three common deformations: ptosis, turn and top-shape.

Abstract
This paper discusses a rectifier inverter composed of two three-leg converters with equal and unequal dc-links voltages connected in series. The operation with equal dc-links voltages divides equally the voltages in each converter. On the other hand, the operation with unequal dc-links voltages increases the number of voltage levels and contributes to reduce harmonic distortion and power losses. Space-vector and level-shifted techniques are discussed. The balance of separated dc sources using redundant voltage vectors is addressed in this paper. A closed-loop controller is used to control the average value of the dc voltages. Simulation results compare power losses and harmonic distortion of three-leg and six-leg topologies. Experimental results are provided to validate the feasibility of the system.

Abstract
Cancer is characterised by somatic genetic variation, but the effect of the majority of non-coding somatic variants and the interface with the germline genome are still unknown. We analysed the whole genome and RNA-seq data from 1,188 human cancer patients as provided by the Pan-cancer Analysis of Whole Genomes (PCAWG) project to map cis expression quantitative trait loci of somatic and germline variation and to uncover the causes of allele-specific expression patterns in human cancers. The availability of the first large-scale dataset with both whole genome and gene expression data enabled us to uncover the effects of the non-coding variation on cancer. In addition to confirming known regulatory effects, we identified novel associations between somatic variation and expression dysregulation, in particular in distal regulatory elements. Finally, we uncovered links between somatic mutational signatures and gene expression changes, including TERT and LMO2, and we explained the inherited risk factors in APOBEC-related mutational processes. This work represents the first large-scale assessment of the effects of both germline and somatic genetic variation on gene expression in cancer and creates a valuable resource cataloguing these effects.

Abstract
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Abstract
The IPP4B workshop assembles a group of researchers from academia and industry - BBC R&D, Ericsson and MOG Technologies - to discuss the state of the art and together envisage future directions for in-programme personalisation in broadcasting. The workshop comprises one invited keynote, two invited presentations together with a paper and discussion sessions.

Abstract
Venous thromboembolism is a pathology that is responsible for high rates of morbidity and mortality in hospitals. An adequate thromboprophylaxis may contribute to an effective improvement of the well-being and safety of patients. One of the important factors for the prescription of a thromboprophylaxis is the determination of the risk of thromboembolism, which can be implemented in several ways, using different methodologies, namely by using risk scales. In this work, developed in the Hospital Center of Tras-os-Montes and Alto Douro, Portugal, we describe the development and implementation of an application with two scales for the assessment and stratification of the risk of thromboembolism, to be applied in hospitalized patients (Caprini scale) and in patients in ambulatory surgery (scale recommended by the Portuguese Ambulatory Surgery Association). The application was integrated into the hospital electronic health record system (SClinico).