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AbstractWith the rapid growth of Deep Learning models and neural networks, the medical data available for training – which is already significantly less than other types of data – is becoming scarce. For that purpose, Generative Adversarial Networks (GANs) have received increased attention due to their ability to synthesize new realistic images. Our preliminary work shows promising results for brain MRI images; however, there is a need to distribute the workload, which can be supported by High-Performance Computing (HPC) environments. In this paper, we generate 256×256 MRI images of the brain in a distributed setting. We obtained an FIDRadImageNetof 10.67 for the DCGAN and 23.54 for the WGAN-GP, which are consistent with results reported in several works published in this scope. This allows us to conclude that distributing the GAN generation process is a viable option to overcome the computational constraints imposed by these models and, therefore, facilitate the generation of new data for training purposes.

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ObjectiveThis systematic review aims to describe the involvement of persons with epilepsy (PWE), healthcare professionals (HP) and caregivers (CG) in the design and development of medical devices is epilepsy.MethodsA systematic review was conducted, adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligibility criteria included peer-reviewed research focusing on medical devices for epilepsy management, involving users (PWE, CG, and HP) during the MDD process. Searches were performed on PubMed, Web of Science, and Scopus, and a total of 55 relevant articles were identified and reviewed.ResultsFrom 1999 to 2023, there was a gradual increase in the number of publications related to user involvement in epilepsy medical device development (MDD), highlighting the growing interest in this field. The medical devices involved in these studies encompassed a range of seizure detection tools, healthcare information systems, vagus nerve stimulation (VNS) and electroencephalogram (EEG) technologies reflecting the emphasis on seizure detection, prediction, and prevention. PWE and CG were the primary users involved, underscoring the importance of their perspectives. Surveys, usability testing, interviews, and focus groups were the methods used for capturing user perspectives. User involvement occurs in four out of the five stages of MDD, with production being the exception.SignificanceUser involvement in the MDD process for epilepsy management is an emerging area of interest holding a significant promise for improving device quality and patient outcomes. This review highlights the need for broader and more effective user involvement, as it currently lags in the development of commercially available medical devices for epilepsy management. Future research should explore the benefits and barriers of user involvement to enhance medical device technologies for epilepsy.Plain Language SummaryThis review covers studies that have involved users in the development process of medical devices for epilepsy. The studies reported here have focused on getting input from people with epilepsy, their caregivers, and healthcare providers. These devices include tools for detecting seizures, stimulating nerves, and tracking brain activity. Most user feedback was gathered through surveys, usability tests, interviews, and focus groups. Users were involved in nearly every stage of device development except production. The review highlights that involving users can improve device quality and patient outcomes, but more effective involvement is needed in commercial device development. Future research should focus on the benefits and challenges of user involvement.

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HAL 9000 is an Intrusion Tolerant Systems (ITSs) Risk Manager, which assesses configuration risks against potential intrusions. It utilizes gathered threat knowledge and remains operational, even in the absence of updated information. Based on its advice, the ITSs can dynamically and proactively adapt to recent threats to minimize and mitigate future intrusions from malicious adversaries. Our goal is to reduce the risk linked to the exploitation of recently uncovered vulnerabilities that have not been classified and/or do not have a script to reproduce the exploit, considering the potential that they may have already been exploited as zero-day exploits. Our experiments demonstrate that the proposed solution can effectively learn and replicate National Vulnerability Database's evaluation process with 99% accuracy.

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Intervention studies have been explored to identify actions to effectively remediate indoor environmental quality (IEQ) problems and to improve people's health, well-being, comfort, and productivity. This study assessed a comprehensive set of IEQ indicators related to ventilation, air pollution, thermal comfort, illuminance, and noise for the first time in Portuguese office buildings. The purpose was to derive evidence-based corrective measures for a further environmental intervention program. The study monitored and surveyed 15 open-space offices from six modern office buildings in Porto (Portugal) during a workday between September and December 2022. Illuminance was of most concern among the assessed IEQ indicators since the measured levels were below the minimum limit required in 27% of the evaluated workplaces. For CO2, although mean concentrations were below 1000 ppm, absolute values exceeding that level were consistently registered in 20% of the offices during the afternoon period. Mean levels of PM2.5, PM10, and ultrafine particles exceeding the WHO guidelines were found in 13%, 7%, and 7% of the offices, respectively. The assessed thermal comfort levels were typically neutral, corresponding to an estimated mean of 6% of dissatisfied people. Based on the findings, an intervention plan was designed to be implemented in the further stages of this work. The priority interventions to test include relocation of printers (PM source removal), optimisation of ventilation rates (using real-time data from CO2 sensors), adjustment of desk positions to improve illuminance, and introduction of indoor plants.

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The integration of artificial intelligence (AI) in medical diagnostics represents a significant advancement in managing upper gastrointestinal (GI) cancer, which is a major cause of global cancer mortality. Specifically for gastric cancer (GC), chronic inflammation causes changes in the mucosa such as atrophy, intestinal metaplasia (IM), dysplasia, and ultimately cancer. Early detection through endoscopic regular surveillance is essential for better outcomes. Foundation models (FMs), which are machine or deep learning models trained on diverse data and applicable to broad use cases, offer a promising solution to enhance the accuracy of endoscopy and its subsequent pathology image analysis. This review explores the recent advancements, applications, and challenges associated with FMs in endoscopy and pathology imaging. We started by elucidating the core principles and architectures underlying these models, including their training methodologies and the pivotal role of large-scale data in developing their predictive capabilities. Moreover, this work discusses emerging trends and future research directions, emphasizing the integration of multimodal data, the development of more robust and equitable models, and the potential for real-time diagnostic support. This review aims to provide a roadmap for researchers and practitioners in navigating the complexities of incorporating FMs into clinical practice for the prevention/management of GC cases, thereby improving patient outcomes.

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