Abstract
The rapid increase of connected devices causes more and more data to be generated and, in some cases, this data needs to be analyzed as it is received. As such, the challenge of presenting streaming data in such way that changes in the regular flow can be detected needs to be tackled, so that timely and informed decisions can be made. This requires users to be able to perceive the information being received in the moment in detail, while maintaining the context. In this paper, we propose VisMillion, a visualization technique for large amounts of streaming data, following the concept of graceful degradation. It is comprised of several different modules positioned side by side, corresponding to different contiguous time spans, from the last few seconds to a historical view of all data received in the stream so far. Data flows through each one from right to left and, the more recent the data, the more detailed it is presented. To this end, each module uses a different technique to aggregate and process information, with special care to ensure visual continuity between modules to facilitate the analysis. VisMillion was validated through a usability evaluation with 21 participants, as well as performance tests. Results show that it fulfills its objective, successfully aiding users to detect changes, patterns and anomalies in the information being received.

Abstract
This paper proposes a two-stage stochastic optimization model to support an aggregator of prosumers in the definition of bids for the day-ahead energy and secondary reserve markets. The aggregator optimizes the prosumers' flexibility with the objective of minimizing the net cost of buying and selling energy and secondary reserve in both day-ahead and real-time market stages. The uncertainties of the renewable generation, consumption, outdoor temperature, prosumers' preferences, and house occupancy are modeled through a set of scenarios. For a case study of 1000 prosumers, the results show that the proposed bidding strategy reduces the costs of both aggregator and prosumers by 40% compared to a bidding strategy typically used by retailers.

Abstract
We present a portable and low-cost system for interrogation of long-period fiber gratings (LPFGs) costing around a 30th of the price of a typical setup using an optical spectrum analyzer and a broadband light source. The unit is capable of performing real-time monitoring or as a stand-alone data-logger. The proposed technique uses three thermally modulated fiber-coupled laser diodes, sweeping a few nanometers around their central wavelength. The light signal is then modulated by the LPFG and its intensity is acquired by a single photo-detector. Through curve-fitting algorithms the sensor transmission spectrum is reconstructed. Testing and validation were accomplished by inducing variations in the spectral features of an LPFG through changes either in external air temperature from 22 to 425 degrees C or in refractive index (RI) of the surrounding medium from 1.3000 to 1.4240. A dynamic resolution between 3.5 and 1.9 degrees C was achieved, in temperatures from 125 to 325 degrees C. In RI measurements, maximum wavelength and optical power deviations of 2.75 nm and 2.86 dB, respectively, were obtained in the range from 1530 to 1570 nm. The worse RI resolution obtained was 3.47x10(-3). The interrogation platform was then applied in the detection of iron corrosion, expressing wavelength peak values within 1.12 nm from the real value in the region between 1530 and 1570 nm.

Abstract
Image segmentation is widely used in image processing, particularly when there is one or few objects of interest. The segmentation of multi-spectral remote sensing images is more challenging due to the large number and diversity of the objects of interest, and the difficulty in having ground truth to tune the segmentation algorithm parameters and to evaluate the results produced. The Synthetic Image TEsting Framework (SITEF) is a tool to address these issues. As the shape and location of the objects in a synthetic image are known, it provides references to be used for quantitative evaluation of the segmentation results. This paper presents SITEF with an experiment to evaluate the segmentation of a SENTINEL-2 image using the software SNAP.

Abstract
Most human protein-coding genes are regulated by multiple, distinct promoters, suggesting that the choice of promoter is as important as its level of transcriptional activity. However, while a global change in transcription is recognized as a defining feature of cancer, the contribution of alternative promoters still remains largely unexplored. Here, we infer active promoters using RNA-seq data from 18,468 cancer and normal samples, demonstrating that alternative promoters are a major contributor to context-specific regulation of transcription. We find that promoters are deregulated across tissues, cancer types, and patients, affecting known cancer genes and novel candidates. For genes with independently regulated promoters, we demonstrate that promoter activity provides a more accurate predictor of patient survival than gene expression. Our study suggests that a dynamic landscape of active promoters shapes the cancer transcriptome, opening new diagnostic avenues and opportunities to further explore the interplay of regulatory mechanisms with transcriptional aberrations in cancer.

Abstract
Hybrid computation harbours discrete and continuous dynamics in the form of an entangled mixture, inherently present in various natural phenomena and in applications ranging from control theory to microbiology. The emergent behaviours bear signs of both computational and physical processes, and thus present difficulties not only in their analysis, but also in describing them adequately in a structural, well-founded way. In order to tackle these issues and, more generally, to investigate hybridness as a dedicated computational phenomenon, we introduce a while-language for hybrid computation inspired by the fine-grain call-by-value paradigm. We equip it with operational and computationally adequate denotational semantics. The latter crucially relies on a hybrid monad supporting an (Elgot) iteration operator that we developed elsewhere. As an intermediate step, we introduce a more lightweight duration semantics furnished with analogous results and based on a new duration monad that we introduce as a lightweight counterpart to the hybrid monad.