Abstract

Abstract
Stroke often leads to severe motor impairment, especially in the upper limbs, greatly reducing a patient’s ability to perform daily tasks. Effective rehabilitation is essential to restore function and improve quality of life. Traditional therapies, while useful, may lack engagement, leading to low motivation and poor adherence. Gamification—using game-like elements in non-game contexts—offers a promising way to make rehabilitation more engaging. The authors explore a gamified rehabilitation system designed in Unity 3D using a Kinect V2 camera. The game includes key features such as adjustable difficulty, real-time and predominantly positive feedback, user friendliness, and data tracking for progress. The evaluations were conducted with 18 healthy participants, most of whom had prior virtual reality experience. About 77% found the application highly motivating. While the gameplay was well received, the visual design was noted as lacking engagement. Importantly, all users agreed that the game offers a broad range of difficulty levels, making it accessible to various users. The results suggest that the system has strong potential to improve rehabilitation outcomes and encourage long-term use through enhanced motivation and interactivity.

Abstract
As storytelling influences consumer attitudes and opinions, conditioning the tourist experience by appealing to the imagination, this paper reviews the literature covering the analysis of 66 papers that focus on the storytelling of the visitor/tourist as the main subject. The article is divided into four main themes: (a) storytelling as a tool to attract tourists; (b) the role of the storyteller; (c) the tourist as a storyteller; and (d) what makes a good story. The Hoshin Kanri Matrix was used to showcase each of the main themes. Although storytelling has been widely used to attract tourists, it is crucial that tourist-based storytelling can be a credible substitute for destination-based storytelling, as empathy, authenticity and the emotional attachment of tourists as storytellers play an important role as good stories, transforming and co-creating their experiences that emerge from the interaction of tourists, residents, and intermediaries.

Abstract
BackgroundTobacco smoke is the main cause of preventable mortality worldwide. Smoking increases the risk of developing many diseases and has been proposed as an aging accelerator. Yet, the molecular mechanisms driving smoking-related health decline and aging acceleration in most tissues remain unexplored.MethodsHere, we use data from the Genotype-Tissue Expression Project (GTEx) to perform a characterization of the effect of cigarette smoking across human tissues. We perform a multi-tissue analysis across 46 human tissues. Our multi-omics characterization includes analysis of gene expression, alternative splicing, DNA methylation, and histological alterations. We further analyze ex-smoker samples to assess the reversibility of these molecular alterations upon smoking cessation.ResultsWe show that smoking impacts tissue architecture and triggers systemic inflammation. We find that in many tissues, the effects of smoking significantly overlap those of aging. Specifically, both age and smoking upregulate inflammatory genes and drive hypomethylation at enhancers (odds ratio (OR) = 2). In addition, we observe widespread smoking-driven hypermethylation at target regions of the Polycomb repressive complex (OR = 2), which is a well-known aging effect. Smoking-induced epigenetic changes overlap causal aging CpGs, suggesting that these methylation changes may directly mediate the aging acceleration observed in smokers. Finally, we find that smoking effects that are shared with aging are more persistent over time.ConclusionOverall, our multi-tissue and multi-omic analysis of the effects of cigarette smoking provides an extensive characterization of the impact of tobacco smoke across tissues and unravels the molecular mechanisms driving smoking-induced tissue homeostasis decline and aging acceleration.

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Abstract
PurposeThis study aims to present an innovative sandbox platform that implements a decision support system (DSS) to assess the sustainable development goals (SDGs) addressed at the municipal level. It intends to determine the relative importance of each SDG in municipalities and explore the synergies that can be discovered among them. Design/methodology/approachParticipatory action research is used to develop a DSS and an algorithm designated as discrete heavy fuzzy was also developed, which extends the Apriori algorithm to include discrete quantitative assessments of the level of SDG compliance by each project. A scenario consisting of three municipalities in Portugal (i.e. Porto, Loule and Castelo de Vide) was chosen to demonstrate the implementation of the sandbox platform and to interpret the observed results. FindingsThe results reveal significant differences in the typology of SDGs addressed by each municipality. It was found that municipal sustainable projects are strongly influenced by the contextual factors of each municipality. Porto has projects that address the first five SDGs. Loule appears projects that promote innovation, the fight against climate change and the development of sustainable cities. Castelo de Vida has initiatives related to innovation and infrastructure and decent work and economic growth. Research limitations/implicationsThis study provides knowledge about the relative importance of the SDGs in Portuguese municipalities and explores the synergies among them. The proposed sandbox platform fills the gaps of the ODSlocal Webtool by proposing a dynamic and interactive approach for the exploration of quantitative indicators regarding the implementation status of the SDGs established in the 2030 Agenda. Originality/valueThis study provides knowledge about the relative importance of the SDGs and the various synergies that exist between them considering the Portuguese municipalities. The sandbox platform presented and developed within this study allows filling the gaps of the ODSlocal Webtool that gathers essentially qualitative information about each project and offers a dynamic and interactive exploration with quantitative indicators of the implementation status of the SDGs established in the 2030 Agenda.