Abstract
SummaryThe muscle synergy concept suggests that the human motor system is organised into functional modules comprised of muscles‘working together’towards common task-goals. This study offers a nuanced computational perspective to muscle synergies, where muscles interacting across multiple scales have functionally-similar, - complementary and -independent roles. Making this viewpoint implicit to a methodological approach applying Partial Information Decomposition to large-scale muscle activations, we unveiled nested networks of functionally diverse inter- and intra-muscular interactions with distinct functional consequences on task performance. This approach’s effectiveness is demonstrated using simulations and by extracting generalisable muscle networks from benchmark datasets of muscle activity. Specific network components are shown to correlate with a) balance performance and b) differences in motor variability between young and older adults. By aligning muscle synergy analysis with leading theoretical insights on movement modularity, the mechanistic insights presented here suggest the proposed methodology offers enhanced research opportunities towards health and engineering applications.

Abstract
Repetitive controllers (RCs) are linear control structures based on the internal model principle. This control strategy is known for its ability to control periodic reference signals, even if these signals have many harmonic components. Despite being a solution that results in a good performance, several parameters of the repetitive controller need to be correctly tuned to guarantee its stability. Among these parameters, one that has high impact on the system performance and stability is the finite impulse response (FIR) filter, which is usually used to increase the stability domain of RC-based controllers. In this context, this paper presents a complete tutorial for designing the zero-phase FIR filter, which is often used to stabilize control systems that use RC-based controllers. In addition, this paper presents a Matlab® application developed for performing the stability analysis of RC systems and designing its FIR filter. Simulation and experimental results of a shunt active power filter are used to validate the algorithm and the Matlab® application.

Abstract
Transthyretin (TTR)-related familial amyloid polyneuropathy (ATTRv) is a life-threatening autosomal dominant disease and the age of onset represents the moment when first symptoms are felt. Accurately predicting the age of onset for a given patient is relevant for risk assessment and treatment management. In this work, we evaluate the impact of combining prediction models obtained from neighboring time windows on prediction error. We propose Symmetric (Sym) and Asymmetric (Asym) models which represent two different averaging approaches. These are incorporated with a weighting mechanism as to create Symmetric (Sym), Symmetric-weighted (Sym-w), Asymmetric (Asym), and Asymmetric-weighted (Asym-w). These four ensemble models are then compared to the original approach which is focused on individual regression base learners namely: Baseline (BL), Decision Tree (DT), Elastic Net (EN), Lasso (LA), Linear Regression (LR), Random Forest (RF), Ridge (RI), Support Vector Regressor (SV) and XGBoost (XG). Our results show that by aggregating predictions from neighbor models the average mean absolute error obtained by each base learner decreases. Overall, the best results are achieved by regression-based ensemble tree models as base learners.

Abstract
Deep Learning (DL) algorithms allow fast results with high accuracy in medical imaging analysis solutions. However, to achieve a desirable performance, they require large amounts of high quality data. Active Learning (AL) is a subfield of DL that aims for more efficient models requiring ideally fewer data, by selecting the most relevant information for training. CheXpert is a Chest X-Ray (CXR) dataset, containing labels for different pathologic findings, alongside a Support Devices (SD) label. The latter contains several misannotations, which may impact the performance of a pathology detection model. The aim of this work is the detection of SDs in CheXpert CXR images and the comparison of the resulting predictions with the original CheXpert SD annotations, using AL approaches. A subset of 10,220 images was selected, manually annotated for SDs and used in the experimentations. In the first experiment, an initial model was trained on the seed dataset (6,200 images from this subset). The second and third approaches consisted in AL random sampling and least confidence techniques. In both of these, the seed dataset was used initially, and more images were iteratively employed. Finally, in the fourth experiment, a model was trained on the full annotated set. The AL least confidence experiment outperformed the remaining approaches, presenting an AUC of 71.10% and showing that training a model with representative information is favorable over training with all labeled data. This model was used to obtain predictions, which can be useful to limit the use of SD mislabelled images in future models.

Abstract
Organizations are more frequently turning towards robotic process automation (RPA) as a solu-tion for employees to focus on higher complexity and more valuable tasks while delegating routine, monotonous and rule-based tasks to their digital colleagues. These software robots can handle various rule-based, digital, repetitive tasks. However, currently available process identi-fication methods must be qualified to select suitable automation processes accurately. Wrong process selection and failed attempts are often the origin of process automation's bad reputation within organizations and often result in the avoidance of this technology. As a result, in this research, a method for selecting processes for automation combining two multi-criteria decision -making techniques, 'Analytic Hierarchy Process (AHP) and Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS), will be proposed, demonstrated, and evaluated. This study follows the Design Science Research Methodology (DSRM) and applies the proposed method for selecting processes for automation to a real-life scenario. The result will be a method to support the proper selection of business processes for automation, increasing the success of implementing RPA tools in an organization.

Abstract
Peripheral arterial disease (PAD) causes blockage of the arteries, altering the blood flow to the lower limbs. This blockage can cause the individual with PAD to feel severe pain in the lower limbs. The main contribution of this research is the discovery of a solution that allows the automatic detection of the onset of claudication based on data analysis from patients' smartphones. For the data-collection procedure, 40 patients were asked to walk with a smartphone on a thirty-meter path, back and forth, for six minutes. Each patient conducted the test twice on two different days. Several machine learning models were compared to detect the onset of claudication on two different datasets. The results suggest that we can identify the onset of claudication using inertial sensors with a best case accuracy of 92.25% for the Extreme Gradient Boosting model.