Abstract
This paper presents a novel approach to the computational representation of cellular lines using transformer-based embeddings. By leveraging state-of-the-art natural language processing techniques, we generate context-aware embeddings from biomedical literature from the PubMed database, offering a more nuanced and biologically relevant representation of cellular lines compared to traditional methods like TF-IDF and SVDD. We applied these embeddings to cluster cellular lines, using the elbow method to identify a set of distinct clusters that reflect biologically meaningful relationships. To evaluate the quality of these clusters, we employed the Topic Coherence metric, achieving a coherence score of 0.395, indicative of moderate consistency across clusters. The results demonstrate the potential of transformer-based models to improve drug discovery by identifying shared characteristics between cellular lines, enabling more accurate drug response predictions and advancing personalized medicine. This method offers an interesting improvement in the precision of cellular line modeling, paving the way for more efficient drug repositioning and targeted therapies in cancer research.

Abstract
The integration of renewable energy and dynamic pricing in European electricity systems requires innovative approaches to manage residential flexibility. This paper presents an elasticity-aware clustering and optimisation framework to jointly model behavioural and asset-based flexibility, addressing gaps in current demand-side management strategies. The methodology comprises three tools: (i) causal inference to estimate consumers' price elasticities, isolating the impact of price variations on consumption; (ii) unsupervised clustering using both elasticity estimates and electric water heater (EWH) load profiles, capturing heterogeneity in flexibility; and (iii) cluster-level optimization for EWH scheduling, minimizing energy usage while preserving user comfort. Simulation results demonstrate measurable reductions in electricity usage across clusters (around 75%). The framework supports aggregators and retailers in designing differentiated market strategies, enhancing coordination in future flexibility markets. By bridging behavioural and operational flexibility, this approach offers relevant insights for residential demand-side management.

Abstract
Abstract. Computing expected information gain (EIG) from prior to posterior (equivalently, mutual information between candidate observations and model parameters or other quantities of interest) is a fundamental challenge in Bayesian optimal experimental design. We formulate flexible transport-based schemes for EIG estimation in general nonlinear/non-Gaussian settings, compatible with both standard and implicit Bayesian models. These schemes are representative of two-stage methods for estimating or bounding EIG using marginal and conditional density estimates. In this setting, we analyze the optimal allocation of samples between training (density estimation) and approximation of the outer prior expectation. We show that with this optimal sample allocation, the mean squared error of the resulting EIG estimator converges more quickly than that of a standard nested Monte Carlo scheme. We then address the estimation of EIG in high dimensions, by deriving gradient-based upper bounds on the mutual information lost by projecting the parameters and/or observations to lower-dimensional subspaces. Minimizing these upper bounds yields projectors and hence low-dimensional EIG approximations that outperform approximations obtained via other linear dimension reduction schemes. Numerical experiments on a PDE-constrained Bayesian inverse problem also illustrate a favorable trade-off between dimension truncation and the modeling of non-Gaussianity, when estimating EIG from finite samples in high dimensions.

Abstract
The present work proposes a two-stage optimization approach for flexibility services provided by battery energy storage systems (BESS) in distribution networks with photovoltaic (PV) generation and electric vehicles (EV). The considered flexibility services include reserve allocation and voltage regulation to support network operation. The first stage optimizes the day-ahead (DA) scheduling of distributed BESS to minimize overall costs, including energy, BESS usage, and reserve, while accounting for stochastic variations in load, PV generation, and EV penetration. The second stage simulates the real-time (RT) operation of the electrical distribution network, evaluating system behavior under different scenarios based on DA decisions. A coordinated control strategy is applied, integrating DA scheduling with network voltage levels. Deviations between BESS outputs in DA and RT stages are fed back into a new DA run to adjust outputs and reduce costs. Results on a medium-voltage distribution system with 157 nodes (based on a reduced version of the EPRI CKT5 feeder) demonstrate that the proposed scenario-based model provides feasible solutions under uncertainty, with BESS playing a key role while strictly adhering to planned operational modes from DA to RT, as typically enforced in energy market participation.

Abstract
With the advent of Information and Communication Technologies in recent decades, organizations face several challenges today. Adopting Digital Transformation (DT) offers numerous opportunities for Small and Medium Enterprises (SMEs) to improve their efficiency and operations, reaching new markets, shareholders, and customers. However, there are potential risks associated with this process. With Digital Transformation (DT), the radius of connectivity and interconnection between devices and systems increases in Mozambique and worldwide, creating more significant space cyberattacks. As Small and Medium-sized Enterprises (SMEs) connect to the digital world and move forward with adopting innovative digital technologies, they become more vulnerable to digital security risks. Hence, managing digital security risks effectively is crucial to realizing the benefits of Digital Transformation (DT). This position paper proposes to present the research work that will culminate in the proposal to develop a framework that fits Mozambican Small and Medium Enterprises (SMEs) through a Design Science Research (DSR) methodology, which can help to assist Mozambican Small and Medium Enterprises (SMEs) in the Digital Transformation (DT) process.

Abstract
Forecasting the covariance matrix of asset returns is central to portfolio construction, risk management, and asset pricing. However, most existing models struggle at medium-term horizons, several weeks to months, where shifting market regimes and slower dynamics prevail. We propose a novel deep learning framework that integrates three-dimensional convolutional neural networks, bidirectional long short-term memory, and multihead attention to capture complex spatiotemporal patterns in asset return dynamics. Using daily data on 14 exchange-traded funds from 2017 to 2023, we demonstrate that our model improves out-of-sample covariance forecasts by reducing Euclidean and Frobenius distance metrics by up to 20% compared with classical benchmarks such as shrinkage estimators and GARCH-type models. These gains persist across distinct market regimes, including bull and bear periods, and remain robust across various forecast horizons and under both raw and excess return specifications. Portfolio simulations based on global minimum variance strategies reveal that the proposed model consistently delivers lower volatility and moderate turnover, even under no-short-selling constraints. This balance between risk reduction and trading efficiency underscores the economic relevance of the forecasts, particularly for institutional investors managing portfolios at medium-term horizons.