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Policymakers often have to make decisions based on incomplete economic data because of the usual delay in publishing official statistics. To circumvent this issue, researchers use data from Google Trends (GT) as an early indicator of economic performance. Such data have emerged in the literature as alternative and complementary predictors of macroeconomic outcomes, such as the unemployment rate, featuring readiness, public availability and no costs. This study deals with extensive daily GT data to develop a framework to nowcast monthly unemployment rates tailored to work with real-time data availability, resorting to Mixed Data Sampling (MIDAS) regressions. Portugal is chosen as a use case for the methodology since extracting GT data requires the selection of culturally dependent keywords. The nowcasting period spans 2019 to 2021, encompassing the time frame in which the coronavirus pandemic initiated. The findings indicate that using daily GT data with MIDAS provides timely and accurate insights into the unemployment rate, especially during the COVID-19 pandemic, showing accuracy gains even when compared to nowcasts obtained from typical monthly GT data via traditional ARMAX models.

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While place attachment has been a hot research topic in tourism, place meanings generally have received less attention from researchers. By bridging environmental psychology to the context of tourism, this research employs schema theory to explore how the home environment influences place meanings perceived in foreign destinations by tourists belonging to the same cultural group, i.e., Chinese and Macau outbound tourists in Europe. Semi-structured interviews were conducted, and the findings show that there is much overlap in both groups' place meanings regarding Europe as they are culturally Chinese. Nonetheless, the Portuguese symbolic settings of their home environment are profoundly integrated in the Macau interviewees' autobiographical memories and self-identity, which turns them into "vicarious insiders" of Portugal prior to their actual visits, thus rendering Portugal a specifically meaningful destination. This study makes theoretical contributions to the tourism place literature and provides practical implications regarding meaning marketing for destination management organizations.

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Purpose This study aims to explore worldwide innovative solutions that have been proposed to mitigate the effects of COVID-19 pandemic on people's mental health. Design/methodology/approach A qualitative methodology is adopted, which performs an exploratory study considering the innovative projects identified by the Observatory for Public Sector Innovation framework. Additionally, the analysis of the relevance and characteristics of these projects are explored considering a multidimensional framework composed of five dimensions: novelty level; social need; improvement of society; sector neutrality; and level of emergence. Findings The findings reveal that the number of projects in the field of mental health is low, despite their strong relevance to their communities. These projects arise from a strong social need to protect especially the most vulnerable groups in this pandemic and involve a large number of partners in the public sector, business and civil society. The role of volunteering in the revitalization and growth of these initiatives is also recognized. Originality/value This study is relevant in both the theoretical and practical dimensions. It allows the exploration of these projects considering the dimensions of social innovation and offers practical implications that allow these projects to be replicated in other countries and regions.

Abstract
Background and Aim: Papillomaviruses (PVs) infections have been documented in numerous animal species across different regions worldwide. They often exert significant impacts on animal health and livestock production. Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer. Acorns (Quercus ilex) are believed to have several unexplored pharmacological properties. This study aimed to evaluate the in vivo safety and cancer chemopreventive activity of an infusion extract of Q. ilex in a transgenic mouse model of human PV (HPV)-16, which developed squamous cell carcinomas through a multistep process driven by HPV16 oncogenes. Materials and Methods: Q. ilex extract was prepared by heating in water at 90 degrees C and then characterized by mass spectrometry. Phenolic compounds from this extract were administered in drinking water to female mice in three different concentrations (0.03, 0.06, and 0.09 g/mL) over a period of 28 consecutive days. Six groups (n = 6) were formed for this study: group 1 (G1, wildtype [WT], water), group 2 (G2, HPV, water), group 3 (G3, WT, 0.09 g/mL), group 4 (G4, HPV, 0.03 g/mL), group 5 (G5, HPV, 0.06 g/ mL), and group 6 (G6, HPV, 0.09 g/mL). Throughout the experiment, humane endpoints, body weight, food intake, and water consumption were recorded weekly. Following the experimental period, all mice were sacrificed, and blood, internal organs, and skin samples were collected. Blood was used to measure glucose and microhematocrit and later biochemical parameters, such as creatinine, urea, albumin, alanine aminotransferase, and total proteins. Histological analysis was performed on skin and organ samples. Results: The administration of Q. ilex extract resulted in a statistically significant increase in relative organ weight among HPV transgenic animals, indicating adaptive biological response to the tested concentrations. Moreover, a reduction in characteristic skin lesions was observed in animals treated with the 0.06 and 0.09 g/mL extract. Conclusion: These results provide a favorable chemopreventive profile for Q. ilex extract at concentrations of 0.06 and 0.09 g/mL. This study highlights the potential of Q. ilex extract as a safe and effective therapeutic strategy against HPV16associated lesions in transgenic mouse models. The limitation of our study was the durability of transgenic animals. As a more sensitive species, we must always be careful with the durability of the test. We intend to study concentrations of 0.06 and 0.09 g/mL for longer to further investigate their possible effects.