Abstract
We consider the problem of linear projection design for incoherent optical imaging systems. We propose a computationally efficient method to obtain effective measurement kernels that satisfy the physical constraints imposed by an optical system, starting first from arbitrary kernels, including those that satisfy a less demanding power constraint. Performance is measured in terms of mutual information between the source input and the projection measurement, as well as reconstruction error for real world images. A clear improvement in the quality of image reconstructions is shown with respect to both random and adaptive projection designs in the literature.

Abstract
Late diagnoses of patients affected by pulmonary artery hypertension (PH) have a poor outcome. This observation has led to a call for earlier, non-invasive PH detection. Cardiac auscultation offers a non-invasive and cost-effective alternative to both right heart catheterization and doppler analysis in analysis of PH. We propose to detect PH via analysis of digital heart sound recordings with over-parameterized deep neural networks. In contrast with previous approaches in the literature, we assess the impact of a pre-processing step aiming to separate S2 sound into the aortic (A2) and pulmonary (P2) components. We obtain an area under the ROC curve of. 95, improving over our adaptation of a state-of-the-art Gaussian mixture model PH detector by +.17. Post-hoc explanations and analysis show that the availability of separated A2 and P2 components contributes significantly to prediction. Analysis of stethoscope heart sound recordings with deep networks is an effective, low-cost and non-invasive solution for the detection of pulmonary hypertension.

Abstract
The George B. Moody PhysioNet Challenge 2022 explored the detection of abnormal heart function from phonocardiogram (PCG) recordings. Although ultrasound imaging is becoming more common for investigating heart defects, the PCG still has the potential to assist with rapid and low-cost screening, and the automated annotation of PCG recordings has the potential to further improve access. Therefore, for this Challenge, we asked participants to design working, open-source algorithms that use PCG recordings to identify heart murmurs and clinical outcomes. This Challenge makes several innovations. First, we sourced 5272 PCG recordings from 1568 patients in Brazil, providing high-quality data for an underrepresented population. Second, we required the Challenge teams to submit working code for training and running their models, improving the reproducibility and reusability of the algorithms. Third, we devised a cost-based evaluation metric that reflects the costs of screening, treatment, and diagnostic errors, facilitating the development of more clinically relevant algorithms. A total of 87 teams submitted 779 algorithms during the Challenge. These algorithms represent a diversity of approaches from both academia and industry for detecting abnormal cardiac function from PCG recordings.

Abstract
This study aimed to build convolutional neural network (CNN) models capable of classifying upper endoscopy images, to determine the stage of infection in the development of a gastric cancer. Two different problems were covered. A first one with a smaller number of categorical classes and a lower degree of detail. A second one, consisting of a larger number of classes, corresponding to each stage of precancerous conditions in the Correa's cascade. Three public datasets were used to build the dataset that served as input for the classification tasks. The CNN models built for this study are capable of identifying the stage of precancerous conditions/lesions in the moment of an upper endoscopy. A model based on the DenseNet169 architecture achieved an average accuracy of 0.72 in discriminating among the different stages of infection. The trade-off between detail in the definition of lesion classes and classification performance has been explored. Results from the application of Grad CAMs to the trained models show that the proposed CNN architectures base their classification output on the extraction of physiologically relevant image features. Clinical relevance - This research could improve the accuracy of upper endoscopy exams, which have margin for improvement, by assisting doctors when analysing the lesions seen in patient's images.

Abstract
The pericardium is a thin membrane sac that covers the heart. As such, the segmentation of the pericardium in computed tomography (CT) can have several clinical applications, namely as a preprocessing step for extraction of different clinical parameters. However, manual segmentation of the pericardium can be challenging, time-consuming and subject to observer variability, which has motivated the development of automatic pericardial segmentation methods. In this study, a method to automatically segment the pericardium in CT using a U-Net framework is proposed. Two datasets were used in this study: the publicly available Cardiac Fat dataset and a private dataset acquired at the hospital centre of Vila Nova de Gaia e Espinho (CHVNGE). The Cardiac Fat database was used for training with two different input sizes - 512 512 and 256 256. A superior performance was obtained with the 256 256 image size, with a mean Dice similarity score (DCS) of 0.871 ± 0.01 and 0.807 ± 0.06 on the Cardiac Fat test set and the CHVNGE dataset, respectively. Results show that reasonable performance can be achieved with a small number of patients for training and an off-the-shelf framework, with only a small decrease in performance in an external dataset. Nevertheless, additional data will increase the robustness of this approach for difficult cases and future approaches must focus on the integration of 3D information for a more accurate segmentation of the lower pericardium.