Abstract
A system using laser speckle effect is proposed to segment images reflecting vibration movements of diffuse targets. Longitudinal movements are difficult to identify when simple imaging systems are used. The proposed system produces a two dimensional segmentation of the target and it is sensitive to longitudinal movements. The speckle effect, produced when coherent light is reflected and interferes when hitting rough surfaces, can be used in order to accomplish this purpose. A pattern with high and low intensity spots is observed depending on the illuminated scene. In our optical system, two silicone membranes are illuminated using a beam expanded laser source and their patterns are recorded using a video camera. One of the membranes experiences a longitudinal controlled movement while the remaining scene is still. Speckle data is processed using a temporal gradient and a regional entropy computation. This method produces a binary individual pixel classification. Four sets of parameters have been tested for the entropy computation and the area under the receiver operating characteristic (ROC) curve was used to select the best one. The selected set-up achieved a ROC value of 0.9879. A data set with 12 different membrane velocities was used to define the threshold that maximizes the classifier accuracy. This threshold was applied to a validation data-set composed by 4 sinusoidal movements with distinct velocities. The accuracy of this technique has achieved values between 92% and 97%. The results show that the target was accurately identified with the optical non-contact apparatus and the developed algorithm.

Abstract
The great incidence of cardiovascular (CV) diseases in the world spurs the search for new solutions to enable an early detection of pathological processes and provides more precise diagnosis based in multi-parameters assessment. The pulse wave velocity (PWV) is considered one of the most important clinical parameters for evaluate the CV risk, vascular adaptation, and therapeutic efficacy. Several studies were dedicated to find the relationship between PWV measurement and pathological status in different diseases, and proved the relevance of this parameter. The commercial devices dedicate to PWV estimation make a regional assessment (measured between two vessels), however a local measurement is more precise evaluation of artery condition, taking into account the differences in the structure of arteries. Moreover, the current devices present some limitations due to the contact nature. Emerging trends in CV monitoring are moving away from more invasive technologies to non-invasive and non-contact solutions. The great challenge is to explore the new instrumental solutions that allow the PWV assessment with fewer approximations for an accurately evaluation and relatively inexpensive techniques in order to be used in the clinical routine.

Abstract

Abstract
Body skin temperature is a useful parameter for diagnosing diseases and infrared thermography can, be a powerful tool in providing important information to detect body temperature changes in a noninvasive way. The aim of this work was to study the pattern of skin temperature during pregnancy, to establish skin temperature reference values and to find correlations between these and the pregnant population characteristics. Sixty-one healthy pregnant women (mean age 30.6 +/- 5.1 years) in the 8th-40th gestational week with normal pregnancies were examined in 31 regions of interest (ROI). The ROIs were defined all over the body in order to determine the most influenced by factors such as age or body mass index (BMI). The results obtained in this work highlight that in normal pregnant women the skin temperature is symmetrically distributed, with the symmetrical areas differing less than 0.5 degrees C, with a mean value of 0.25 +/- 0.23 degrees C. This study identified a significant negative correlation between the BMI and temperature. Age has been shown to have great influence on the skin temperature, with a significant increase of temperature observed with age. This work explores a novel medical application of infrared thermography and provides a characterization of thermal skin profile in human pregnancy for a large set of ROIs while also evaluating the effects of age and BMI.

Abstract
A multi-wavelengths analysis for pulse waveform extraction using laser speckle is conducted. The proposed system consists of three coherent light sources (532 nm, 635 nm, 850 nm). A bench-test composed of a moving skin-like phantom (silicone membrane) is used to compare the results obtained from different wavelengths. The system is able to identify a skin-like phantom vibration frequency, within physiological values, with a minimum error of 0.5 mHz for the 635 nm and 850 nm wavelengths and a minimum error of 1.3 mHz for the 532 nm light wavelength using a FFT-based algorithm. The phantom velocity profile is estimated with an error ranging from 27% to 9% using a bidimensional correlation coefficient-based algorithm. An in vivo trial is also conducted, using the 532 nm and 635 nm laser sources. The 850 nm light source has not been able to extract the pulse waveform. The heart rate is identified with a minimum error of 0.48 beats per minute for the 532 nm light source and a minimal error of 1.15 beats per minute for the 635 nm light source. Our work reveals that a laser speckle-based system with a 532 nm wavelength is able to give arterial pulse waveform with better results than those given with a 635 nm laser.

Abstract
The ability to detect pathological changes early and in a non-invasive way represents important advantages in the medical field. Diagnosis should become less intrusive, more accurate and less expensive in order to implement in the clinical routine. Infrared thermography has the advantages of being non-invasive, fast, reliable, capable of producing multiple recordings in short intervals, and absolutely safe for patients and clinicians. Thermographic image (TI) came to be an extensively studied technique to quantify sensitive changes in skin temperature in relation to certain diseases: early in the pathological process (lesions, inflammation and infection) the circulation fluxes are altered and, consequently, the tissues’ temperature is reflected in thermography pattern, before structural or functional changes can be observed. This technique proved to be able to give relevant clinical information, such as breast cancer, foot disease in diabetes, rheumatoid arthritis and sports injuries. Monitoring the temperature profile of a patient will allow understanding the physiological evolution of some diseases or monitoring the pharmacologic therapy effect. However, the high cost of this technology and the small number of commercial solutions do not allow a general implementation in the clinical environmental. The future direction is the combination of this technique with the other images techniques in order to add clinical information for a more reliable diagnostic.