Abstract
The clinical relevance of pulse wave velocity (PWV), as an indicator of cardiac risk associated to arterial stiffness, has gained clinical relevance over the last years. Optic sensors are an attractive instrumental solution for this type of measurement due to their truly non-contact operation capability, which has the potential of an interference free measurement. The nature of the optically originated signals, however, poses new challenges to the designer, either at the probe design level as at the signal processing required to extract the timing information that yields PWV. In this work we describe the construction of two prototype optical probes and discuss their evaluation using three algorithms for pulse transit time (PTT) evaluation. Results, obtained in a dedicated test bench, that is also described, demonstrate the possibility of measuring pulse transit times as short as 1ms with less than 1% error. © Springer-Verlag Berlin Heidelberg 2013.

Abstract
Sub-millimetre distension waveforms (0.7 mm, max) are assessed using two new optical probes. The probes differ on the type of photo-detector used: planar photodiodes (PPD), in one case, and avalanche photodiodes (APD), in the other. Performance of the probes is evaluated in an especially developed test setup and in vivo, at the carotid site of humans. In the latter case, distension (associated to the pressure wave generated by the left ventricle contraction that propagates through the arterial system) carries clinically relevant information that can be extracted if, as will be shown, the waveforms are accurate and have enough resolution. An ultrasound image system, Vivid" e, was used as source of reference data for comparison. Along with the probes, a set of software routines was also developed to extract artefact-free data and evaluate the error. Results from the test setup demonstrate the possibility of waveform distension measurements with less than 6% error for both optical probes in this study. In comparison with an ultrasound system, the optical sensors allow the reproduction of the arterial waveform with a higher resolution, adequate to feed feature extraction algorithms.

Abstract
The non-invasive assessment of hemodynamic parameters has been a permanent challenge posed to the scientific community. The literature shows many contributions to this quest expressed as algorithms dedicated to revealing some of its characteristics and as new probes or electronics, featuring some enhanced instrumental capability that can improve their insight. A test system capable of replicating some of the basic properties of the cardiovascular system, especially the ones related with the propagation of the arterial pressure wave (APW), is a powerful tool in the development of those probes and in the validation of the various algorithms that extract clinically relevant information from the data that they can collect. This work describes a test bench system, based on the combination of a new programmable pressure wave generator with a flexible tube, capable of emulating some of these properties. It discusses its main characterization issues and demonstrates the system in a relevant case study. Two versions of the system have been set up: one that generates a short duration pulse-like pressure wave from an actuator operated in a switched mode, appropriate to system characterization; a second one, using a long stroke actuator, linearly operated under program control, capable of generating complex, including cardiac-like, pressure waveforms. This configuration finds its main use in algorithm test and validation. Tests with a new piezoelectric probe, designed to collect the APW at the major artery sites are shown, demonstrating the possibility of non-invasive precise recovery of the pressure waveform.

Abstract
Local pulse-wave velocity (PWV) is an accurate indicator of the degree of arteriosclerosis (stiffness) in an artery, providing a direct characterization of the properties of its wall. Devices currently available for local PWV measurement are mainly based on ultrasound systems and have not yet been generalized to clinical practice since they require high technical expertise and most of them are limited in precision, due to the lack of reliable signal processing methods. The present work describes a new type of probe, based on a double-headed piezoelectric (PZ) sensor. The principle of PWV measurement involves determination of the pulse transit time between the signals acquired simultaneously by both PZs, placed 23 mm apart. The double probe (DP) characterization is accomplished in three main studies, carried out in a dedicated test bench system, capable of reproducing a range of clinically relevant properties of the cardiovascular system. The first study refers to determination of the impulse response (IR) for each PZ sensor, whereas the second one explores the existence of crosstalk between both transducers. In the last one, DP time resolution is inferred from a set of three different algorithms based on (a) the maximum of cross-correlation function, (b) the maximum amplitude detection and (c) the zero-crossing point identification. These values were compared with those obtained by the reference method, which consists of the simultaneous acquisition of pressure waves by means of two pressure sensors. The new probe demonstrates good performance on the test bench system and results show that the signals do not exhibit crosstalk. A good agreement was also verified between the PWV obtained from the DP signals (19.55 +/- 2.02 ms(-1)) and the PWV determined using the reference method (19.26 +/- 0.04 ms(-1)). Although additional studies are still required, this probe seems to be a valid alternative to local PWV stand-alone devices.

Abstract
Local pulse-wave velocity (PWV) is recognized as the simplest and most reproducible process of non-invasively assessing the vascular marker of arterial stiffness that allowing the risk of cardiovascular diseases to be determinate. Devices currently available for local PWV measurement have not yet been generalized to clinical practice since they require high technical expertise and most of them are limited in precision, due to the lack of reliable signal processing methods. This work describes a new type of probes, based on a piezoelectric sensor in different configurations, single probe and double probe. The principle of PWV measurement involves determination of the pulse transit time between the signals acquired simultaneously by both piezoelectric placed 23 mm apart in the same probe. The double probe characterization is accomplished in different studies, carried out in a dedicated test bench system, capable of reproducing a range of clinically relevant properties of the cardiovascular system.

Abstract
This paper envisages showing the potential of innovative non-invasive techniques based on affordable and easily operated instrumentation as well as user-friendly computer aided algorithms in the screening of cardiovascular (CV) diseases. These techniques are based on the assumption that arterial stiffness is currently an important predicator of the CV diseases development and can be assessed by analyzing the arterial pressure waveform (APW). A previously developed PZ based device for non-invasive APW capture is currently under test in clinical environment, using a heterogeneous population constituted by healthy and unhealthy subjects. A dedicated Matlab analysis tool was designed and developed to extract relevant information and further APW analysis. Several recordings of the APW in the same day and in consecutive months are being performed by trained observers, to evaluate its reproducibility. Data mining analysis is subsequently the last task where the Weka 3-6-5 package software is used. The usefulness of developing data mining algorithms for cardiovascular applications can benefit the CV screenings contributing for the early identification of arterial stiffness related patterns.