Abstract
The coronavirus disease 2019 (COVID-19) pandemic has impacted healthcare systems across the world. Chest radiography (CXR) can be used as a complementary method for diagnosing/following COVID-19 patients. However, experience level and workload of technicians and radiologists may affect the decision process. Recent studies suggest that deep learning can be used to assess CXRs, providing an important second opinion for radiologists and technicians in the decision process, and super-human performance in detection of COVID-19 has been reported in multiple studies. In this study, the clinical applicability of deep learning systems for COVID-19 screening was assessed by testing the performance of deep learning systems for the detection of COVID-19. Specifically, four datasets were used: (1) a collection of multiple public datasets (284.793 CXRs); (2) BIMCV dataset (16.631 CXRs); (3) COVIDGR (852 CXRs) and 4) a private dataset (6.361 CXRs). All datasets were collected retrospectively and consist of only frontal CXR views. A ResNet-18 was trained on each of the datasets for the detection of COVID-19. It is shown that a high dataset bias was present, leading to high performance in intradataset train-test scenarios (area under the curve 0.55-0.84 on the collection of public datasets). Significantly lower performances were obtained in interdataset train-test scenarios however (area under the curve > 0.98). A subset of the data was then assessed by radiologists for comparison to the automatic systems. Finetuning with radiologist annotations significantly increased performance across datasets (area under the curve 0.61-0.88) and improved the attention on clinical findings in positive COVID-19 CXRs. Nevertheless, tests on CXRs from different hospital services indicate that the screening performance of CXR and automatic systems is limited (area under the curve < 0.6 on emergency service CXRs). However, COVID-19 manifestations can be accurately detected when present, motivating the use of these tools for evaluating disease progression on mild to severe COVID-19 patients.

Abstract
Businesses that are growing by supplying more services or reaching more customers, might need to create or relocate a facility location to expand their geographical coverage and improve their services. This decision is complex, and it is crucial to analyse their client locations, their journeys and be aware of the factors that may affect their geographical decision and the impact that they can have in the business strategy. Therefore, the decision-maker needs to ensure that the location is the most profitable site according to the business scope and future perspectives. In this paper, we propose a decision support system to help businesses on this complex decision that is capable of providing facility location suggestions based on their journeys analysis and the factors that the decision-makers consider more relevant to the company. The system helps the business managers to make better decisions by returning facility locations that have potential to maximise the company’s profit by reducing costs and maximise the number of covered customers by expanding their territorial coverage. To verify and validate the decision support system, a system evaluation was developed. Thus, a survey was responded by decision-makers in order to evaluate the efficiency, understandability, accuracy and effectiveness of the suggestions. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Abstract
Cardiac auscultation is the key exam to screen cardiac diseases both in developed and developing countries. A heart sound auscultation procedure can detect the presence of murmurs and point to a diagnosis, thus it is an important first-line assessment and also cost-effective tool. The design automatic recommendation systems based on heart sound auscultation can play an important role in boosting the accuracy and the pervasiveness of screening tools. One such as step, consists in detecting the fundamental heart sound states, a process known as segmentation. A faulty segmentation or a wrong estimation of the heart rate might result in an incapability of heart sound classifiers to detect abnormal waves, such as murmurs. In the process of understanding the impact of a faulty segmentation, several common heart sound segmentation errors are studied in detail, namely those where the heart rate is badly estimated and those where S1/S2 and Systolic/Diastolic states are swapped in comparison with the ground truth state sequence. From the tested algorithms, support vector machine (SVMs) and random forest (RFs) shown to be more sensitive to a wrong estimation of the heart rate (an expected drop of 6% and 8% on the overall performance, respectively) than to a swap in the state sequence of events (an expected drop of 1.9% and 4.6%, respectively).

Abstract
In hospital and after ICU discharge deaths are usual, given the severity of the condition under which many of them are admitted to these wings. Because of this, there is an urge to identify and follow these cases closely. Furthermore, as ICU data is usually composed of variables measured in varying time intervals, there is a need for a method that can capture causal relationships in this type of data. To solve this problem, we propose ItsPC, a causal Bayesian network that can model irregular multivariate time-series data. The preliminary results show that ItsPC creates smaller and more concise networks while maintaining the temporal properties. Moreover, its irregular approach to time-series can capture more relationships with the target than the Dynamic Bayesian Networks.

Abstract
Typically, classification algorithms use correlation analysis to make decisions. However, these decisions and the models they learn are not easily understandable for the typical user. Causal discovery is the field that studies the means to find causal relationships in observational data. Although highly interpretable, causal discovery algorithms tend to not perform so well in classification problems. This paper aims to propose a hybrid decision tree approach (SC tree) that mixes causal discovery with correlation analysis through the implementation of a custom metric to split the data in the tree's construction (Semi-causal gain ratio). In the results, the proposed methodology obtained a significant performance improvement (11.26% mean error rate) when compared to several causal baselines CDT-PS (23.67% ) and CDT-SPS (25.14%), matching closely the performance of J48 (10.20%), used as a correlation baseline, in ten binary data sets. Besides, when compared with PC in discrete data sets, the proposed approach obtained substantial improvement (16.17% against 28.07% in terms of mean error rate).

Abstract
Cardiac auscultation is still the most cost-effective screening procedure for cardiovascular diseases. The development of computer assisted methods can empower a large variety of health professionals and thus enable mass cardiac health low-cost screening. The procedure for correct cardiac auscultation includes listening to the heart sounds of the four main auscultation spots. Until recently, attempts to develop automatic heart sound analysis methods that explore the multi-channel richness of a real auscultation, were very difficult due to the lack of adequate public datasets. In this work, we use the CirCor Dataset which is characterized by the existence of more than one heart sound per patient (each patient has heart sounds collected at different auscultation spots). Using this dataset, we evaluate and quantify the comparative impact of using a single or a multichannel approach. A single channel approach uses the sound from a single auscultation spot, whereas a multi-channel approach uses four auscultation spots in an asynchronous way. From the different classifiers tested, models that use four auscultation spots achieved a higher overall performance than those that search for abnormalities in a single heart sound spot. Our best result is a multi-channel SVM that analyzes four auscultation spots, with an overall performance of 87,4 %. This opens the path to future research using a multi-channel approach.