Abstract
Production and distribution problems with perishable goods are common in many industries. For the sake of the competitiveness of the companies, the supply chain planning of products with restricted lifespan should be addressed with an integrated approach. Particularly, at the operational level, the sizing and scheduling of production lots have to be decided together with vehicle routing decisions to satisfy the customers. However, such joint decisions make the problems hard to solve for industries with a large product portfolio. This paper proposes an adaptive large neighbourhood search (ALNS) framework to tackle the problem. This metaheuristic is well known to be effective for vehicle routing problems. The proposed approach relies on mixed-integer linear programming models and tools. The ALNS outperforms traditional procedures of the literature, namely, exact methods and fix-and-optimize, in terms of quality of the solution and computational time of the algorithms. Nine in ten runs of ALNS yielded better solutions than traditional procedures, outperforming on average 12.7% over the best solutions provided by the latter methods.

Abstract
Lot sizing and scheduling by mixed integer programming has been a hot research topic inthe last 20 years. Researchers have been trying to develop stronger formulations, as well as to incorporatereal-world requirements from different applications. This paper illustrates some of these requirements anddemonstrates how small- and big-bucket models have been adapted and extended. Motivation comes fromdifferent industries, especially from process and fast-moving consumer goods industries. © 2015 Brazilian Operations Research Society.

Abstract
Lot sizing and scheduling by mixed integer programming has been a hot research topic in the last 20 years. Researchers have been trying to develop stronger formulations, as well as to incorporate real-world requirements from different applications. In this paper we illustrate some of these requirements and show howmodels have been adapted and extended. Motivation comes from different industries, especially from process and fast moving consumer goods industries.

Abstract
In this paper, the main complexities related to the modeling of production planning problems of food products are addressed. We start with a deterministic base model and build a road-map on how to incorporate key features of food production planning. The different "ingredients" are organized around the model components to be extended: constraints, objective functions and parameters. We cover issues such as expiry dates, customers' behavior, discarding costs, value of freshness and age-dependent demand. To understand the impact of these "ingredients", we solve an illustrative example with each corresponding model and analyze the changes on the solution structure of the production plan. The differences across the solutions show the importance of choosing a model suitable to the particular business setting, in order to accommodate the multiple challenges present in these industries. Moreover, acknowledging the perishable nature of the products and evaluating the amount and quality of information at hands may be crucial in lowering overall costs and achieving higher service levels. Afterwards, the deterministic base model is extended to deal with an uncertain demand parameter and risk management issues are discussed using a similar illustrative example. Results indicate the increased importance of risk-management in the production planning of perishable food goods.

Abstract
This paper addresses the lot-sizing and scheduling problem of pulp and paper mills involving multiple paper machines. The underlying multi-stage integrated production process considers the following critical units: continuous digester, intermediate stocks of pulp and liquor, multiple paper machines and a recovery line to treat by-products. This work presents a mixed integer programming (MIP) model to represent the problem, as well as a solution approach based on a customized genetic algorithm (GA) with an embedded residual linear programming model. Some GA tools are explored, including literature and new operators, a novel diversification process and other features. In particular, the diversification process uses a new allele frequency measure to change between diversification and intensification procedures. Computational results show the effectiveness of the method to solve relatively large instances of the single paper machine problem when compared to other single paper machine solution methods found in the literature. For multiple paper machine settings, in most runs the GA solutions are better than those obtained for the MIP model using an optimization software.

Abstract
The classical multi-level capacitated lot-sizing problem formulation is often not suitable to correctly capture resource requirements and precedence relations. Depending on lead time assumptions, either the model provides infeasible production plans or plans with costly needless inventory. We tackle this issue by explicitly modeling these two aspects and the synchronization of batches of products in the multi-level lot-sizing and scheduling formulation. Two models are presented; one considering batch production and the other one allowing lot-streaming. Comparisons with traditional models demonstrate the capability of the new approach in delivering more realistic results. The generated production plans are always feasible and cost savings of 30-40 percent compared to classical models are observed.