Abstract
For reconfigurable radios where the signals can be easily routed from one band to another band, new radio frequency switches (RF) are a fundament. The main factor driving the power consumption of the reconfigurable intelligent system (RIS) is the need for an intermediate device with static power consumption to maintain a certain surface configuration state. Since power usage scales quadratically with the RIS area, there is a relevant interest in mitigating this drawback so that this technology can be applied to everyday objects without needing such a high intrinsic power consumption. Current switch technologies such as PIN diodes, and field effect transistors (FETs) are volatile electronic devices, resulting in high static power. In addition, dynamic power dissipation related to switching event is also considerable. Regarding energy efficiency, non-volatile radio frequency resistive switch (RFRS) concept may be better alternative solution due to several advantages: smaller area, zero-hold voltage, lower actuation bias for operation, short switching time, scalability and capable to be fabricated in the backend-of-line of standard CMOS process.

Abstract
Future telecommunications aim to be ubiquitous and efficient, as widely deployed connectivity will allow for a variety of edge/fog based services. Challenges are numerous, e.g., spectrum overuse, energy efficiency, latency and bandwidth, battery life and computing power of edge devices. Addressing these challenges is key to compose the backbone for the future Internet-of-Things (IoT). Among IoT applications are Indoor Positioning System and indoor Real-Time-Location-Systems systems, which are needed where GPS is unviable. The Bluetooth Low Energy (BLE) 5.1 specification introduced Direction Finding to the protocol, allowing for BLE devices with antenna arrays to derive the Angle-of-Arrival (AoA) of transmissions. Well known algorithms for AoA calculation are computationally demanding, so recent works have addressed this, since the low-cost of BLE devices may provide efficient solutions for indoor localization. In this paper, we present a system topology and algorithms for self-localization where a receiver with an antenna array utilizes the AoAs from fixed battery powered beacons to self-localize, without a centralized system or wall-power infrastructure. We conduct two main experiments using a BLE receiver of our own design. Firstly, we validate the expected behaviour in an anechoic chamber, computing the AoA with an RMSE of 10.7 degrees conduct a test in an outdoor area of 12 by 12 meters using four beacons, and present pre-processing steps prior to computing the AoAs, followed by position estimations achieving a mean absolute error of 3.6 m for 21 map positions, with a minimum as low as 1.1 m.

Abstract
PPG signal is a valuable resource for continuous heart rate monitoring; however, this signal suffers from artifact movements, which is particularly relevant during physical exercise and makes this biomedical signal difficult to use for heart rate detection during those activities. The purpose of this study was to develop learning models to determine heart rate using data from wearables (PPG and acceleration signals) and dealing with noise during physical exercise. Learning models based on CNNs and LSTMs were developed to predict the heart rate. The PPG signal was combined with data from accelerometers trying to overcome the noise movement on the PPG signal. Two datasets were used on this work: the 2015 IEEE Signal Processing Cup (SPC) dataset was used for training and testing, and another dataset was used for validation of the learning model (PPG-DaLiA dataset). The predictions obtained by the learning model represented a mean average error of 7.033±5.376 bpm for the SCP dataset, while a mean average error of 9.520±8.443 bpm for the validation set. The use of acceleration data increases the performance of the learning models on the prediction of the heart rate, showing the benefits of using this source of data to overcome the noise movement problem on the PPG signal. The combination of PPG signal with acceleration data could allow the learning models to use more information regarding the motion artifacts that affect the PPG and improve performance on the physiological event detections, which will largely spread the use of wearables on the healthcare applications for continuous monitor the physiological state allowing early and accurate detection of pathological events.

Abstract
Amongst the different types of cancer, lung cancer is the one with the highest mortality rate and consequently, there is an urgent need to develop early detection methods to improve the survival probabilities of the patients. Due to the millions of deaths that are caused annually by cancer, there is large interest int the scientific community to developed deep learning models that can be employed in computer aided diagnostic tools.Currently, in the literature, there are several works in the Radiomics field that try to develop new solutions by employing learning models for lung nodule classification. However, in these types of application, it is usually required to extract the lung nodule from the input images, while using a segmentation mask made by a radiologist. This means that in a clinical scenario, to be able to employ the developed learning models, it is required first to manually segment the lung nodule. Considering the fact that several patients are attended daily in the hospital with suspicion of lung cancer, the segmentation of each lung nodule would become a tiresome task. Furthermore, the available algorithms for automatic lung nodule segmentation are not efficient enough to be used in a real application.In response to the current limitations of the state of the art, the proposed work attempts to evaluate a multitasking approach where both the segmentation and the classification task are executed in parallel. As a baseline, we also study a sequential approach where first we employ DL models to segment the lung nodule, corp the lung nodule from the input image and then finally, we classify the cropped nodule. Our results show that the multitasking approach is better than to sequentially execute the segmentation and classification task for lung nodule classification. For instances, while the multitasking approach was able to achieve an AUC of 84.49% in the classification task, the sequential approach was only able to achieve an AUC of 72.43%. These results show that the proposed multitasking approach can become a viable alternative to the classification and segmentation of lung nodules.

Abstract
Bone marrow edema (BME) or bone marrow lesion is the term attributed to an observed signal change within the bone marrow in magnetic resonance imaging (MRI). BME can be originated from multiple mechanisms, with pain being the main symptom. The presence of BME is an unspecific but sensitive sign with a wide differential diagnosis, that may act as a guide that leads to a systematic and correct interpretation of the magnetic resonance examination. An automatic approach for BME detection and quantification aims to reduce the overload of clinicians, decreasing human error and accelerating the time to the correct diagnosis. In this work, the bone region on the MRI slice was split into several patches and a CNN-based model was trained to detect BME in each patch from the MRI slice. The learning model developed achieved an AUC of 0.853 ± 0.056, showing that the CNN-based model can be used to detect BME in the MRI and confirming the patch strategy implemented to deal with the small data size and allowing the neural network to learn the specific information related with the classification task by reducing the region of the image to be considered. A learning model that can help clinicians with BME identification will decrease the time and the error for the diagnosis, and represent the first step for a more objective assessment of the BME.

Abstract
Microsatellite Instability (MSI) is an important biomarker in cancer patients, showing a defective DNA mismatch repair system. Its detection allows the use of immunotherapy to treat cancer, an approach that is revolutionizing cancer treatment. MSI is especially relevant for three types of cancer: Colon Adenocarcinoma (COAD), Stomach Adenocarcinoma (STAD), and Uterus corpus endometrial cancer (UCEC). In this work, learning algorithms were employed to predict MSI using RNA-seq data from The Cancer Genome Atlas (TCGA) database, with a focus on the selection of the most informative genomic features. The Multi-Layer Perceptron (MLP) obtained the best score (AUC = 98.44%), showing that it is possible to exploit information from RNA-seq data to find relevant relationships with the instability levels of microsatellites (MS). The accurate prediction of MSI with transcription data from cancer patients will help with the correct determination of MSI status and adequate prescription of immunotherapy, creating more precise and personalized patient care. At the genetic level, the study revealed a high expression of genes related to cell regulation functions, and a low expression of genes responsible for Mismatch Repair functions, in patients with high instability.