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Publications

Publications by CTM

2024

Analysis of the experimental absorption spectrum of the rabbit lung and identification of its components

Authors
Pinheiro, MR; Tuchin, VV; Oliveira, LM;

Publication
JOURNAL OF BIOPHOTONICS

Abstract
The broadband absorption coefficient spectrum of the rabbit lung presents some particular characteristics that allow the identification of the chromophores in this tissue. By performing a weighted combination of the absorption spectra of water, hemoglobin, DNA, proteins and the pigments melanin and lipofuscin, it was possible to obtain a good match to the experimental absorption spectrum of the lung. Such reconstruction provided reasonable information about the contents of the tissue components in the lung tissue, and allowed to identify a similar accumulation of melanin and lipofuscin. The broadband absorption coefficient spectrum of the rabbit lung was reconstructed from the absorption spectra of tissue components. The similar accumulation of melanin and lipofuscin was retrieved from the broadband baseline in the absorption coefficient spectrum, and the calculation of the absorption fold ratios for proteins, DNA and hemoglobin provided good results. The method used is innovative and can be improved to allow the quantification of tissue components concentrations directly. image

2024

Light in evaluation of molecular diffusion in tissues: Discrimination of pathologies

Authors
Oliveira, LR; Pinheiro, MR; Tuchina, DK; Timoshina, PA; Carvalho, MI; Oliveira, LM;

Publication
ADVANCED DRUG DELIVERY REVIEWS

Abstract
The evaluation of the diffusion properties of different molecules in tissues is a subject of great interest in various fields, such as dermatology/cosmetology, clinical medicine, implantology and food preservation. In this review, a discussion of recent studies that used kinetic spectroscopy measurements to evaluate such diffusion properties in various tissues is made. By immersing ex vivo tissues in agents or by topical application of those agents in vivo, their diffusion properties can be evaluated by kinetic collimated transmittance or diffuse reflectance spectroscopy. Using this method, recent studies were able to discriminate the diffusion properties of agents between healthy and diseased tissues, especially in the cases of cancer and diabetes mellitus. In the case of cancer, it was also possible to evaluate an increase of 5% in the mobile water content from the healthy to the cancerous colorectal and kidney tissues. Considering the application of some agents to living organisms or food products to protect them from deterioration during low temperature preservation (cryopreservation), and knowing that such agent inclusion may be reversed, some studies in these fields are also discussed. Considering the broadband application of the optical spectroscopy evaluation of the diffusion properties of agents in tissues and the physiological diagnostic data that such method can acquire, further studies concerning the optimization of fruit sweetness or evaluation of poison diffusion in tissues or antidote application for treatment optimization purposes are indicated as future perspectives.

2024

Precise Identification of Different Cervical Intraepithelial Neoplasia (CIN) Stages, Using Biomedical Engineering Combined with Data Mining and Machine Learning

Authors
Kruczkowski, M; Drabik-Kruczkowska, A; Wesolowski, R; Kloska, A; Pinheiro, MR; Fernandes, L; Galan, SG;

Publication
Interdisciplinary Cancer Research

Abstract

2024

Feature Extraction from EEG signals for detection of Parkinsons Disease

Authors
Souza, C; Viana, G; Coelho, B; Massaranduba, AB; Ramos, R;

Publication
Anais do XVI Congresso Brasileiro de Inteligência Computacional

Abstract
The Electroencephalogram (EEG) is a medical tool that captures, in a non-invasive way, electrical signals from the brain activities performed by neurons. EEG signals have been the target of study as a biomarker of Parkinsons disease (PD), where several methods of analysis are applied. The present work aims to evaluate features extracted from EEG signals, through methodologies such as HOS, Haralick descriptors, and Fractal Features, as new biomarkers for PD identification. Data from 50 individuals, available at the Open Neuro repository, who underwent an attentional cognitive task were analyzed. RF and SVM algorithms were employed for the classification of the extracted features. The best accuracy achieved was 79.49% in differentiating between Parkinsons subjects and control subjects using Haralick descriptors and RF classifier, suggesting that these features can identify activations in brain areas caused by dopaminergic medication.

2024

On the feasibility of Vis–NIR spectroscopy and machine learning for real time SARS-CoV-2 detection

Authors
Coelho, BFO; Nunes, SLP; de França, CA; Costa, DdS; do Carmo, RF; Prates, RM; Filho, EFS; Ramos, RP;

Publication
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Abstract

2024

A Comparative Analysis of Resource-Efficient Machine Learning Models in News Categorization

Authors
Zolfagharnasb, MH; Damari, S;

Publication
U.Porto Journal of Engineering

Abstract
The constant stream of news nowadays highlights the necessity for meticulous assessment to ensure that the information accurately reaches its intended audience with the least amount of delay least delay. Despite the flexibility and efficiency of Deep Learning (DL) models, their intricate training and substantial resource demands pose significant challenges for their deployment in real-time applications. In this regard, this study evaluates the performance of resource-efficient Machine Learning (ML) techniques – Multinomial Naive Bayes (MNB), Random Forest (RF), Support Vector Machine (SVM), and Logistic Regression (LR) – in categorizing news. Based on the results, all the evaluated models attain a commendable level of accuracy in news categorization. Notably, the SVM excels, achieving an accuracy rate of 98% and a mean squared error of 0.28. This performance exemplifies the robust effectiveness of classical ML models in the categorization of news, particularly when enhanced by a suitably tailored preprocessing pipeline. © 2024, Universidade do Porto - Faculdade de Engenharia. All rights reserved.

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