Abstract
Diabetic retinopathy (DR) is the leading cause of blindness in adults. In diabetes, there is activation of microglial cells and a concomitant release of inflammatory mediators. However, it remains unclear how diabetes triggers an inflammatory response in the retina. Activation of P2 purinergic receptors by adenosine triphosphate (ATP) may contribute to the inflammatory response in the retina, insofar as it has been shown to be associated with microglial activation and cytokine release. In this work, we evaluated how high glucose, used as a model of hyperglycemia, considered the main factor in the development of DR, affects the extracellular levels of ATP in retinal cell cultures. We found that basal extracellular ATP levels were not affected by high glucose or mannitol, but the extracellular elevation of ATP, after a depolarizing stimulus, was significantly higher in retinal cells cultured in high glucose compared with control or mannitol-treated cells. The increase in the extracellular ATP was prevented by application of botulinum neurotoxin A or by removal of extracellular calcium. In addition, degradation of exogenously added ATP was significantly lower in high-glucose-treated cells. It was also observed that, in retinal cells cultured under high-glucose conditions, the changes in the intracellular calcium concentrations were greater than those in control or mannitol-treated cells. In conclusion, in this work we have shown that high glucose alters the purinergic signaling system in the retina, by increasing the exocytotic release of ATP and decreasing its extracellular degradation. The resulting high levels of extracellular ATP may lead to inflammation involved in the pathogenesis of DR. (C) 2008 Wiley-Liss, Inc.

Abstract
Variable-length codes, using source statistical features, improve the encoding. However, using these codes can results in error propagation in bit string transmitted to noisy transmission environments. This paper has used reversible symmetrical codes in the bit string obtained from JPEG compressor in order to overcome this problem. several examples of reversible code design algorithm have been reviewed and a symmetrical code based on Huffman code has been analyzed and deigned for JPEG compressor Jpeg compressor has been simulated by Huffman standard code and by reversible symmetrical code and the amount of their compression has been compared for several pictures Also, optimization of detection trend in noisy condition has been displayed. © 2009 IEEE.

Abstract
Complete optical characterization of biological tissue is desirable to develop clinical methods using optical technologies. Particularly, to develop optical clearing methods in biological tissues, it is necessary to know the composition of the tissue, the percentage of each constituent and corresponding refractive indexes. To obtain such information for rat muscle, we used a simple method to characterize tissue constituents for both content percentage and refractive index. The study consisted on measuring mass with a precision weighting scale and the refractive index with an Abbe refractometer during tissue dehydration. With the collected data, we used a theoretical model to calculate the refractive index and percentage for both interstitial fluid and solid part of the rat muscle. The results obtained are in good agreement with data published by other authors, and were considered of vital information for the optical clearing studies that we planned to perform.

Abstract
A procedure is proposed to estimate an analogue-to-digital converter's signal-to-noise plus distortion ratio using the histogram method. The procedure provides results that are in close agreement with the ones obtained with the spectral analysis and sinewave fitting methods. It is shown that the errors obtained by using former implementations of the histogram method are due to not considering the input stimulus probability density function, and it is shown how these errors can be rectified.

Abstract
Currently, the bandwidth utilization of residential broadband links is highly inefficient. Providing the means for sharing these links will increase the total bandwidth and reduce the fixed costs per client thus promoting the use of Internet services. This paper proposes a low cost communal residential gateway for sharing and remotely managing broadband access links. We first identify and characterize existing problems on residential asymmetric link sharing scenarios and then propose and evaluate the CommGate prototype that overcomes these problems. This solution contributes to an efficient broadband link sharing, a cost breakdown and an increasing Internet access dissemination, particularly in developing countries.

Abstract
With the increasing number of devices carried by users and the emergence of more dynamic network scenarios, new solutions have to be developed to support ubiquitous communications. The need for dynamic and transparent auto-configuration and adaptation of applications, devices and networks of devices to a wide variety of events is one of the major challenges. This paper presents a protocol to be used with notification systems, to support the registration, subscription and distribution of generic events among heterogeneous and independent entities, thus addressing the requirements of future communication scenarios.