Abstract
Lung diseases affect the lives of billions of people worldwide, and 4 million people, each year, die prematurely due to this condition. These pathologies are characterized by specific imagiological findings in CT scans. The traditional Computer-Aided Diagnosis (CAD) approaches have been showing promising results to help clinicians; however, CADs normally consider a small part of the medical image for analysis, excluding possible relevant information for clinical evaluation. Multiple Instance Learning (MIL) approach takes into consideration different small pieces that are relevant for the final classification and creates a comprehensive analysis of pathophysiological changes. This study uses MIL-based approaches to identify the presence of lung pathophysiological findings in CT scans for the characterization of lung disease development. This work was focus on the detection of the following: Fibrosis, Emphysema, Satellite Nodules in Primary Lesion Lobe, Nodules in Contralateral Lung and Ground Glass, being Fibrosis and Emphysema the ones with more outstanding results, reaching an Area Under the Curve (AUC) of 0.89 and 0.72, respectively. Additionally, the MIL-based approach was used for EGFR mutation status prediction - the most relevant oncogene on lung cancer, with an AUC of 0.69. The results showed that this comprehensive approach can be a useful tool for lung pathophysiological characterization.

Abstract
We study the time-dependent behavior of dissipative solitons (DSs) stabilized by nonlinear gradient terms. Two cases are investigated: first, the case of the presence of a Raman term, and second, the simultaneous presence of two nonlinear gradient terms, the Raman term and the dispersion of nonlinear gain. As possible types of time-dependence, we find a number of different possibilities including periodic behavior, quasi-periodic behavior, and also chaos. These different types of time-dependence are found to form quite frequently from a window structure of alternating behavior, for example, of periodic and quasi-periodic behaviors. To analyze the time dependence, we exploit extensively time series and Fourier transforms. We discuss in detail quantitatively the question whether all the DSs found for the cubic complex Ginzburg-Landau equation with nonlinear gradient terms are generic, meaning whether they are stable against structural perturbations, for example, to the additions of a small quintic perturbation as it arises naturally in an envelope equation framework. Finally, we examine to what extent it is possible to have different types of DSs for fixed parameter values in the equation by just varying the initial conditions, for example, by using narrow and high vs broad and low amplitudes. These results indicate an overlapping multi-basin structure in parameter space. Published under an exclusive license by AIP Publishing.

Abstract
Pulp and Paper Companies collaborate to monitor and monetize waste and create value from their by-products. This process of Industrial Symbiosis requires the creation and maintenance of trusted and transparent relationships between all entities participating in these networks, which is a constant challenge. In this context, a blockchain-based system can help in establishing and maintaining these networks, serving as a ground truth between companies operating at a national or a global scale. This paper proposes a scalable and modular blockchain architecture design using smart contracts to enhance the industrial symbiosis process of the Pulp, Paper, and Cardboard Production Sector companies in Portugal. This design comprehends all entities participating in the network. The implementation of this design assumes the use of a permissioned ledger built using Hyperledger Fabric to provide the required trust and transparency between all entities.

Abstract
Messaging services are usually provided within social network platforms and allow these platforms to collect additional information about users, such as what time, for how long, with whom, and where a user communicates. This information allows the identification of users and is available to the messaging service provider even when communication is encrypted end-to-end. Thus, a gap still exists for alternative messaging services that enable anonymous and confidential communication and that are independent of a specific online service. Online services can still be used to support this messaging service, but in a way that enables users to communicate anonymously and without the knowledge and scrutiny of the online services. In this paper, we propose messaging using steganography and online services to support anonymous and confidential communication. In the proposed messaging service, only the sender and the receiver are aware of the existence of the exchanged data, even if the online services used or other third parties have access to the exchanged secret data containers. This work reviews the viability of using existing online services to support the proposed messaging service. Moreover, a proof-of-concept of the proposed message service is implemented and tested using two online services acting as proxies in the exchange of encrypted information disguised within images and links to those images. The obtained results confirm the viability of such a messaging service.

Abstract
[No abstract available]

Abstract
Low Power Wide Area Networks (LPWAN) are used worldwide in several Internet of Things (IoT) applications that rely on large-scale deployments. Despite most of these networks include their own security mechanisms with built-in encryption, they are still vulnerable to a range of attacks that can be performed using low-cost Software Defined Radio (SDR) hardware and low-complexity techniques. This work provides an experimental setup implemented to exploit physical layer vulnerabilities with SDR techniques. Several attack vectors typically related to LPWAN within the IoT ecosystem are implemented and tested such as Global Positioning (GPS) Spoofing, Replay Attacks, Denial-of-Service (DoS) and Jamming, in environments that rely specifically on LoRaWAN networks. The results show that, in LoRAWAN networks, a set of vulnerabilities can be exploited leading to the incorrect functioning of the executed applications, and possible damage to the systems in which they operate. It was possible to verify that, depending on the type of activation method used between the devices and the LoRaWAN server, the communications and the devices can be compromised.