Abstract
Due to the high variability in Hematoxylin and Eosin (H&E)-stained Whole Slide Images (WSIs), hidden stratification, and batch effects, generalizing beyond the training distribution is one of the main challenges in Deep Learning (DL) for Computational Pathology (CPath). But although DL depends on large volumes of diverse and annotated data, it is common to have a significant number of annotated samples from one or multiple source distributions, and another partially annotated or unlabeled dataset representing a target distribution for which we want to generalize, the so-called Domain Adaptation (DA). In this work, we focus on the task of generalizing from a single source distribution to a target domain. As it is still not clear which domain adaptation strategy is best suited for CPath, we evaluate three different DA strategies, namely FixMatch, CycleGAN, and a self-supervised feature extractor, and show that DA is still a challenge in CPath.

Abstract
Anomaly Detection has been a significant field in Machine Learning since it began gaining traction. In the context of Computer Vision, the increased interest is notorious as it enables the development of video processing models for different tasks without the need for a cumbersome effort with the annotation of possible events, that may be under represented. From the predominant strategies, weakly and semi-supervised, the former has demonstrated potential to achieve a higher score in its analysis, adding to its flexibility. This work shows that using temporal ranking constraints for Multiple Instance Learning can increase the performance of these models, allowing the focus on the most informative instances. Moreover, the results suggest that altering the ranking process to include information about adjacent instances generates best-performing models.

Abstract
[No abstract available]

Abstract
In order to facilitate the adoption of deep learning in areas where decisions are of critical importance, understanding the model's internal workings is paramount. Nevertheless, since most models are considered black boxes, this task is usually not trivial, especially when the user does not have access to the network's intermediate outputs. In this paper, we propose IBISA, a model-agnostic attribution method that reaches stateof-the-art performance by optimizing sampling masks using the Information Bottleneck Principle. Our method improves on the previously known RISE and IBA techniques by placing the bottleneck right after the image input without complex formulations to estimate the mutual information. The method also requires only twenty forward passes and ten backward passes through the network, which is significantly faster than RISE, which needs at least 4000 forward passes. We evaluated IBISA using a VGG-16 and a ResNET-50 model, showing that our method produces explanations comparable or superior to IBA, RISE, and Grad-CAM but much efficiently.

Abstract

Abstract
Quality control of medical images is a critical component of digital pathology, ensuring that diagnostic images meet required standards. A pre-analytical task within this process is the verification of the number of specimen fragments, a process that ensures that the number of fragments on a slide matches the number documented in the macroscopic report. This step is important to ensure that the slides contain the appropriate diagnostic material from the grossing process, thereby guaranteeing the accuracy of subsequent microscopic examination and diagnosis. Traditionally, this assessment is performed manually, requiring significant time and effort while being subject to significant variability due to its subjective nature. To address these challenges, this study explores an automated approach to fragment counting using the YOLOv11 and Vision Transformer models. Our results demonstrate that the automated system achieves a level of performance comparable or even superior to that of experts, offering a reliable and efficient alternative to manual counting. Additionally, we present findings on interobserver variability, showing that the automated approach achieves an accuracy of 90.1%, surpassing the range observed among experts (82-88%). This result further supports its suitability for integration into routine pathology workflows. © 2025 IEEE.