Publications

Publications by CAP

2017

Separation of temperature and strain in a single fiber BOTDA system by pseudo-inverse approach

Authors
Lima dos Reis Marques, F; Floridia, C; Alves Almeida, T; Leonardi, AA; Fruett, F;

Publication
2017 SBMO/IEEE MTT-S International Microwave and Optoelectronics Conference (IMOC)

Abstract

2017

FSO applied to optical fiber sensing: A field test demonstration

Authors
Rosolem, JB; Penze, RS; Floridia, C; Dini, DC; Peres, R; do Nascimento, CAM; Valadares, JEF;

Publication
2017 SBMO/IEEE MTT-S International Microwave and Optoelectronics Conference (IMOC)

Abstract

2017

Evaluation of FBG sensors to measure ultrasonic guided waves in rail transport monitoring

Authors
Rezende Cano, WF; Batista Rosolem, J; Florida, C; de Oliveira Lopes, PH; Dini, DC; Strobel Penze, R; Ferreira da Costa, E; Vicentini Fracarolli, JP;

Publication
2017 SBMO/IEEE MTT-S International Microwave and Optoelectronics Conference (IMOC)

Abstract

2017

Distributed high birefringence localization based in polarization OTDR converter: A field demonstration

Authors
Floridia, C; Rosolem, JB;

Publication
2017 SBMO/IEEE MTT-S International Microwave and Optoelectronics Conference (IMOC)

Abstract

2017

Real-time multiple machines sound listening using a phase-OTDR based distributed microphone

Authors
Franciscangelis, C; Fruett, F; Margulis, W; Kjellberg, L; Floridia, C;

Publication
2017 SBMO/IEEE MTT-S International Microwave and Optoelectronics Conference (IMOC)

Abstract

2017

Development of hydroxybenzoic-based platforms as a solution to deliver dietary antioxidants to mitochondria

Authors
Teixeira, J; Oliveira, C; Amorim, R; Cagide, F; Garrido, J; Ribeiro, JA; Pereira, CM; Silva, AF; Andrade, PB; Oliveira, PJ; Borges, F;

Publication
SCIENTIFIC REPORTS

Abstract
Oxidative stress and mitochondrial dysfunction have been associated with metabolic and agerelated diseases. Thus, the prevention of mitochondrial oxidative damage is nowadays a recognized pharmacological strategy to delay disease progression. Epidemiological studies suggested an association between the consumption of polyphenol-rich diet and the prevention of different pathologies, including diseases with a mitochondrial etiology. The development of mitochondrialtargeted antioxidants based on dietary antioxidants may decrease mitochondrial oxidative damage. Herein, we report the design and synthesis of two new mitochondriotropic antioxidants based on hydroxybenzoic acids (AntiOxBENs). The results obtained showed that the novel antioxidants are accumulated inside rat liver mitochondria driven by the organelle transmembrane electric potential and prevented lipid peroxidation, exhibiting low toxicity. Some of the observed effects on mitochondrial bioenergetics resulted from an increase of proton leakage through the mitochondrial inner membrane. The new derivatives present a higher lipophilicity than the parent compounds (protocatechuic and gallic acids) and similar antioxidant and iron chelating properties. AntiOxBENs are valid mitochondriotropic antioxidant prototypes, which can be optimized and used in a next future as drug candidates to prevent or slow mitochondrial oxidative stress associated to several pathologies.

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