2021
Authors
Perez Herrera, RA; Bravo, M; Leandro, D; Novais, S; Pradas, J; Lopez Amo, M;
Publication
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
Abstract
In this work, a multi-parameter point sensor based on the combination of Fabry-Perot (FP) and the anti-resonant (AR) reflecting guidance in cascade configuration is proposed and experimentally demonstrated. This structure, based on FP interference and AR reflecting guidance, was fabricated with two different air micro-cavities. The attained experimental results showed different strain and temperature sensitivities for the antiresonance contribution. However, when analyzing the FP interference, only strain sensitivity was observed, demonstrating that this air micro-cavity was also insensitive to temperature variations.
2021
Authors
Rosolem, JB; Penze, RS; Floridia, C; Peres, R; Vasconcelos, D; Ramos Junior, MA;
Publication
Sensors
Abstract
2021
Authors
Silva, AdA; Floridia, C; Rosolem, JB;
Publication
Sensors
Abstract
2021
Authors
Rosolem, JB; Penze, RS; Floridia, C; Bassan, FR; Peres, R; Costa, EFd; de Araujo Silva, A; Coral, AD; Junior, JRN; Vasconcelos, D; Junior, MAR;
Publication
IEEE Sensors Journal
Abstract
2021
Authors
Bassan, FR; Rosolem, JB; Floridia, C; Aires, BN; Peres, R; Aprea, JF; Nascimento, CAM; Fruett, F;
Publication
Sensors
Abstract
2021
Authors
Rebelo, TSCR; Ribeiro, JA; Sales, MGF; Pereira, CM;
Publication
SENSING AND BIO-SENSING RESEARCH
Abstract
This work reports the development of a simple and rapid electrochemical immunosensor for the determination of breast cancer biomarker Cancer Antigen 15-3 (CA 15-3). Disposable and cost-effective chips, consisting of gold screen-printed electrodes (AuSPEs), were used to develop the portable electrochemical devices for monitoring the biomarker in point-of-care (PoC), under clinical context. The biosensor preparation consisted of two simple steps. First, a self-assembled monolayer (SAM) of mercaptosuccinic acid (MSA) was formed at the AuSPE surface. Then, the CA 15-3 antibody was covalently bound to the carboxylic groups standing at the electrode surface using EDC/NHS chemistry. The performance of the developed immunosensor was evaluated by assessing the sensor sensitivity, linear response interval, selectivity and detection limit (LOD). The developed immunosensor provided a wide linear concentration range (from 1.0 to 1000 U mL(-1)) and low detection levels were achieved (LOD of 0.95 U mL(-1)), enabling the sensitive detection of the cancer biomarker at clinically relevant levels, using square wave voltammetry (SWV) as electroanalytical technique. Moreover, selectivity studies performed against other cancer biomarkers (CA 125 and CA 19-9) revealed that the antibody has high selectivity for CA 15-3 antigen. The immunosensor was applied to the quantification of CA 15-3 in artificial serum samples with satisfactory results.
The access to the final selection minute is only available to applicants.
Please check the confirmation e-mail of your application to obtain the access code.