Abstract
Production and distribution problems with perishable goods are common in many industries. For the sake of the competitiveness of the companies, the supply chain planning of products with restricted lifespan should be addressed with an integrated approach. Particularly, at the operational level, the sizing and scheduling of production lots have to be decided together with vehicle routing decisions to satisfy the customers. However, such joint decisions make the problems hard to solve for industries with a large product portfolio. This paper proposes an adaptive large neighbourhood search (ALNS) framework to tackle the problem. This metaheuristic is well known to be effective for vehicle routing problems. The proposed approach relies on mixed-integer linear programming models and tools. The ALNS outperforms traditional procedures of the literature, namely, exact methods and fix-and-optimize, in terms of quality of the solution and computational time of the algorithms. Nine in ten runs of ALNS yielded better solutions than traditional procedures, outperforming on average 12.7% over the best solutions provided by the latter methods.

Abstract
Assessing firms' Eco-efficiency is important to ensure they succeed in creating wealth without compromising the needs of future generations. This work aims to extend the Eco-efficiency concept by including in the assessment new features related to environmental benefits. Eco-efficiency is evaluated using a DEA model specified with a Directional Distance Function. The new methodology proposed in this paper is illustrated with an application to world-class mining companies, whose results and managerial implications are discussed.

Abstract
Kidney exchange programs (KEPs) allow the exchange of kidneys between incompatible donor-recipient pairs. Optimization approaches can help KEPs in defining which transplants should be made among all incompatible pairs according to some objective. The most common objective is to maximize the number of transplants. In this paper, we propose an integer programming model which addresses the objective of maximizing the expected number of transplants, given that there are equal probabilities of failure associated with vertices and arcs. The model is compact, i.e. has a polynomial number of decision variables and constraints, and therefore can be solved directly by a general purpose integer programming solver (e.g. Cplex).

Abstract
The bivalve dredge fleet, considered as one of the most important artisanal fleets due to the high value of the catches, is by far the most extensively studied among the Portuguese artisanal segment. Acknowledging the growing presence of marine phycotoxins in the waters, the present study explores their impact on the revenue of the fleet that operates along the coast of mainland Portugal. The results obtained using stochastic frontier analysis models enlighten the harmful impact of algae blooms on the activity of the artisanal dredge fleets. In particular, it was observed that in the Algarve region, where the frequency and the intensity of these episodes is higher, the sustainability of the dredge fishing activity is seriously compromised by the phycotoxins.

Abstract
Collecting and transporting solid waste is a constant problem for municipalities and populations in general. Waste management should take into account the preservation of the environment and the reduction of costs. The goal with this paper is to address a real-life solid waste problem. The case reveals some general and specific characteristics which are not rare, but are not widely addressed in the literature. Furthermore, new methods and models to deal with sectorization and routing are introduced, which can be extended to other applications. Sectorization and routing are tackled following a two-phase approach. In the first phase, a new method is described for sectorization based on electromagnetism and Coulomb's Law. The second phase addresses the routing problems in each sector. The paper addresses not only territorial division, but also the frequency with which waste is collected, which is a critical issue in these types of applications. Special characteristics related to the number and type of deposition points were also a motivation for this work. A new model for a Mixed Capacitated Arc Routing Problem with Limited Multi-Landfills is proposed and tested in real instances. The computational results achieved confirm the effectiveness of the entire approach.

Abstract
This paper discusses different models that can be used to construct composite indicators with both desirable and undesirable output indicators. Two approaches are considered. The first is an indirect approach, based on a traditional Data Envelopment Analysis model, requiring a prior transformation in the measurement scale of the undesirable outputs. The second is a direct approach, based on a directional distance function model. The use of a directional distance function allows for the accommodation of undesirable indicators in their original form. The main limitations of these approaches are discussed related to the data transformation in the case of the indirect approach and the possibility to obtain negative margin rates of substitution between the desirable and undesirable outputs in the case of the direct approach. These issues lead to the proposal of a new composite indicator model based on a directional distance function that overcomes the limitations associated with the existing approaches. The incorporation of information on the relative importance of individual indicators using weight restrictions is discussed. Proposed here is an enhanced formulation of weight restrictions, in the form of assurance regions type I, that reflects the relative importance of the indicators in percentage terms. The models are illustrated in the assessment of Brazilian hydropower plants and are suitable for any assessment involving the aggregation of key performance indicators whenever undesirable outputs are present.