Abstract
Solid-phasetemplate-assisted mechanosynthesis of Fe-N-C,featuring low-cost and sustainable FeCl3, 2,4,6-tri(2-pyridyl)-1,3,5-triazine(TPTZ), and NaCl is reported. Efficient and sustainable synthesis of performant metal/nitrogen-dopedcarbon (M-N-C) catalysts for oxygen reduction and evolutionreactions (ORR/OER) is vital for the global switch to green energytechnologies-fuel cells and metal-air batteries. Thisstudy reports a solid-phase template-assisted mechanosynthesis ofFe-N-C, featuring low-cost and sustainable FeCl3, 2,4,6-tri(2-pyridyl)-1,3,5-triazine (TPTZ), and NaCl. ANaCl-templated Fe-TPTZ metal-organic material was formed usingfacile liquid-assisted grinding/compression. With NaCl, the Fe-TPTZtemplate-induced stability allows for a rapid, thus, energy-efficientpyrolysis. Among the produced materials, 3D-FeNC-LAG exhibits remarkableperformance in ORR (E (1/2) = 0.85 V and E (onset) = 1.00 V), OER (E ( j=10) = 1.73 V), and in the zinc-airbattery test (power density of 139 mW cm(-2)). Themultilayer stream mapping (MSM) framework is presented as a tool forcreating a sustainability assessment protocol for the catalyst productionprocess. MSM employs time, cost, resource, and energy efficiency astechnoeconomic sustainability metrics to assess the potential upstreamimpact. MSM analysis shows that the 3D-FeNC-LAG synthesis exhibits90% overall process efficiency and 97.67% cost efficiency. The proposedsynthetic protocol requires 2 times less processing time and 3 timesless energy without compromising the catalyst efficiency, superiorto the most advanced methods.

Abstract
Background: Digital clinical tools are a new technology that can be used in the screening or diagnosis of obstructive sleep apnea (OSA), notwithstanding the crucial role of polysomnography, the gold standard.Objective: This study aimed to identify, gather, and analyze the most accurate digital tools and smartphone-based health platforms used for OSA screening or diagnosis in the adult population. Methods: We performed a comprehensive literature search of PubMed, Scopus, and Web of Science databases for studies evaluating the validity of digital tools in OSA screening or diagnosis until November 2022. The risk of bias was assessed using the Joanna Briggs Institute critical appraisal tool for diagnostic test accuracy studies. The sensitivity, specificity, and area under the curve (AUC) were used as discrimination measures.Results: We retrieved 1714 articles, 41 (2.39%) of which were included in the study. From these 41 articles, we found 7 (17%) smartphone-based tools, 10 (24%) wearables, 11 (27%) bed or mattress sensors, 5 (12%) nasal airflow devices, and 8 (20%) other sensors that did not fit the previous categories. Only 8 (20%) of the 41 studies performed external validation of the developed tool. Of these, the highest reported values for AUC, sensitivity, and specificity were 0.99, 96%, and 92%, respectively, for a clinical cutoff of apnea-hypopnea index (AHI)& GE;30. These values correspond to a noncontact audio recorder that records sleep sounds, which are then analyzed by a deep learning technique that automatically detects sleep apnea events, calculates the AHI, and identifies OSA. Looking at the studies that only internally validated their models, the work that reported the highest accuracy measures showed AUC, sensitivity, and specificity values of 1.00, 100%, and 96%, respectively, for a clinical cutoff AHI & GE;30. It uses the Sonomat-a foam mattress that, aside from recording breath sounds, has pressure sensors that generate voltage when deformed, thus detecting respiratory movements, and uses it to classify OSA events.Conclusions: These clinical tools presented promising results with high discrimination measures (best results reached AUC>0.99). However, there is still a need for quality studies comparing the developed tools with the gold standard and validating them in external populations and other environments before they can be used in clinical settings.

Abstract
The rapid growth of the scientific literature makes text classification essential specially in the biomedical research domain to help researchers to focus on the latest findings in a fast and efficient way. The potential benefits of using text semantic enrichment to enhance the biomedical document classification is presented in this study. We show the importance of enriching the corpora with semantic information to improve the full-text classification. The approach involves the semantic enrichment of a Medline corpus with a Semantic Repository (SemRep) which extracts semantic predications from biomedical text. The study also addresses the problem of treating highly dimensional data while maintaining the semantic structure of the corpus. Experimental results lead to the sustained conclusion that better results are achieved with full-text instead of using only abstracts and titles. We also conclude that the application of enriched techniques to full-texts significantly improves the task of text classification providing a significant contribution for the biomedical text mining research.

Abstract
Eating behavior adopted during adolescence may persist into adulthood. The aims of this study were to identify eating behavior patterns among Portuguese adolescents and to explore whether groups differ in terms of early life and family characteristics, severity of depressive symptoms, and body mass index (BMI) z-score. Participants were 3601 13-year-olds enrolled in the birth cohort Generation XXI. Eating behavior was assessed using the self-reported Adult Eating Behavior Questionnaire (AEBQ), validated in this sample. The severity of depressive symptoms was measured through the Beck Depression Inventory (BDI-II), and data on sociodemographic and anthropometrics were collected at birth and 13-years-old. Latent class analysis was conducted, and associations were estimated using multinomial logistic regression models. Five patterns of individuals were identified: Picky eating, Disinterest towards food, Food neophilia, Emotional eating, and Food attractiveness. The adolescents' sex, maternal education, BMI z-score, and severity of depressive symptoms were significantly associated with the identified patterns. In particular, adolescents with a higher BMI z-score were more likely in Food neophilia while individuals with more severe depressive symptoms were in the Picky eating, Emotional eating, and Food attractiveness patterns. These findings suggest a starting point for the development and planning of targeted public health interventions.

Abstract
Human-Robot Collaboration is a critical component of Industry 4.0, contributing to a transition towards more flexible production systems that are quickly adjustable to changing production requirements. This paper aims to increase the natural collaboration level of a robotic engine assembly station by proposing a cognitive system powered by computer vision and deep learning to interpret implicit communication cues of the operator. The proposed system, which is based on a residual convolutional neural network with 34 layers and a long -short term memory recurrent neural network (ResNet-34 + LSTM), obtains assembly context through action recognition of the tasks performed by the operator. The assembly context was then integrated in a collaborative assembly plan capable of autonomously commanding the robot tasks. The proposed model showed a great performance, achieving an accuracy of 96.65% and a temporal mean intersection over union (mIoU) of 94.11% for the action recognition of the considered assembly. Moreover, a task-oriented evaluation showed that the proposed cognitive system was able to leverage the performed human action recognition to command the adequate robot actions with near-perfect accuracy. As such, the proposed system was considered as successful at increasing the natural collaboration level of the considered assembly station.

Abstract
In recent years, scientific and technological advances in robotics, have enabled the development of disruptive solutions for human interaction with the real world. In particular, the application of robotics to support people with physical disabilities, improved their life quality with a high social impact. This paper presents a stereo image based perception solution for autonomous wheelchairs navigation. It was developed to extend the Intellwheels project, a development platform for intelligent wheelchairs. The current version of Intellwheels relies on a planar scanning sensor, the Laser Range Finder (LRF), to detect the surrounding obstacles. The need for robust navigation capabilities means that the robot is required to precept not only obstacles but also bumps and holes on the ground. The proposed stereo-based solution, supported in passive stereo ZED cameras, was evaluated in a 3D simulated world scenario designed with a challenging floor. The performance of the wheelchair navigation with three different configurations was compared: first, using a LRF sensor, next with an unfiltered stereo camera and finally, applying a stereo camera with a speckle filter. The LRF solution was unable to complete the planned navigation. The unfiltered stereo camera completed the challenge with a low navigation quality due to noise. The filtered stereo camera reached the target position with a nearly optimal path.