Abstract
In addition to evaluating tumor morphology using H&E staining, immunohistochemistry is used to assess the presence of specific proteins within the tissue. However, this is a costly and labor-intensive technique, for which virtual staining, as an image-to-image translation task, offers a promising alternative. Although recent, this is an emerging field of research with 64% of published studies just in 2024. Most studies use publicly available datasets of H&E-IHC pairs from consecutive tissue sections. Recognizing the training challenges, many authors develop complex virtual staining models based on conditional Generative Adversarial Networks but ignore the impact of adversarial loss on the quality of virtual staining. Furthermore, overlooking the issues of model evaluation, they claim improved performance based on metrics such as SSIM and PSNR, which are not sufficiently robust to evaluate the quality of virtually stained images. In this paper, we developed CSSP2P GAN, which we demonstrate to achieve heightened pathological fidelity through a blind pathological expert evaluation. Furthermore, while iteratively developing our model, we study the impact of the adversarial loss and demonstrate its crucial role in the quality of virtually stained images. Finally, while comparing our model with reference works in the field, we underscore the limitations of the currently used evaluation metrics and demonstrate the superior performance of CSSP2P GAN.

Abstract
This work reflects upon what Immersion can mean from the perspective of an Artificial Intelligence (AI). Applying the lens of immersive learning theory, it seeks to understand whether this new perspective supports ways for AI participation in cognitive ecologies. By treating AI as a participant rather than a tool, it explores what other participants (humans and other AIs) need to consider in environments where AI can meaningfully engage and contribute to the cognitive ecology, and what the implications are for designing such learning environments. Drawing from the three conceptual dimensions of immersion-System, Narrative, and Agency-this work reinterprets AIs in immersive learning contexts. It outlines practical implications for designing learning environments where AIs are surrounded by external digital services, can interpret a narrative of origins, changes, and structural developments in data, and dynamically respond, making operational and tactical decisions that shape human-AI collaboration. Finally, this work suggests how these insights might influence the future of AI training, proposing that immersive learning theory can inform the development of AIs capable of evolving beyond static models. This paper paves the way for understanding AI as an immersive learner and participant in evolving human-AI cognitive ecosystems.

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Abstract
To achieve further performance and efficiency, System-onChip (SoC) designs increasingly rely on core customization or integration of application-specific hardware blocks. This requires extensive efforts during Design Space Exploration (DSE) of new hardware to achieve integration, correctness, and target performance. This is time-consuming and error-prone, hindering fast iterative hardware/software co-design. This paper presents a co-simulation framework which integrates arbitrary high-level simulators into Verilog-based SoC platforms, demonstrated on the RISC-V–based open-source X-HEEP SoC. Using inter-process communication we enable cycle-accurate lock-step co-simulation where high-level simulators of accelerators are exposed as memory-mapped peripherals to the RISC-V core. For experimental validation we re-implemented an existing peripheral of the X-HEEP SoC written in Register-Transfer Level (RTL) as an external simulator process, and observed that the co-simulated version maintains identical cycle-level behavior with a maximum wall-clock overhead of 11%. This work enables fast DSEs of heterogeneous RISC-V–based SoCs. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2026.

Abstract
Large language models (LLMs) have shown astonishing capability of generating software code, leading to its use to support developers in programming. Proposed tools have relied either on assistants for improved auto-complete or multi-agents, in which different model instances are orchestrated to perform parts of a problem to reach a complete solution. We argue that LLMs can enable a higher-level of abstraction, a new paradigm we called Test-Oriented Programming (TOP). Within this paradigm, developers only have to check test code generated based on natural language specifications, rather than focusing on production code, which could be delegated to the LLMs. To evaluate the feasibility of this proposal, we developed a proof-of-concept tool and used it to generate a small command-line program employing two different LLMs. We obtained promising results and identified challenges for the use of this paradigm for real projects. © 2026 Copyright held by the owner/author(s).