Abstract

Abstract
The increasing penetration of distributed energy resources based on renewable energy sources in distribution systems leads to a more complex management of power systems. Consequently, ancillary services become even more important to maintain the system security and reliability. This paper proposes and evaluates a generic model for day-ahead, intraday (hour-ahead) and real-time scheduling, considering the joint optimization of energy and reserve in the scope of the virtual power player concept. The model aims to minimize the operation costs in the point of view of one aggregator agent taking into account the balance of the distribution system. For each scheduling stage, previous scheduling results and updated forecasts are considered. An illustrative test case of a distribution network with 33 buses, considering a large penetration of distribution energy resources allows demonstrating the benefits of the proposed model.

Abstract
Short-term load forecasting plays an important role to the operation of electric systems, as a key parameter for planning maintenances and to support the decision making process on the purchase and sale of electric power. A particular case in this respect is the consumption forecasting on special days, which can be a complex task as it presents unusual load behavior, when compared to regular working days. Moreover, its reduced number of samples makes it hard to properly train and validate more complex and nonlinear prediction algorithms. This paper tackles this problem by proposing a new approach to improve the accuracy of the predictions amidst existing special days, employing an Information Theoretic Learning Mean Shift algorithm for pattern discovery, classifying and densifying the available scarce consumption data. The paper describes how this methodology was applied to an electrical load forecasting problem in the northern region of Brazil, improving the previously obtained accuracy held by the power company.

Abstract
The prevalence of data science has grown exponentially in recent years. Increases in data exchange have created the need for standards and formats on handling data from different sources. Developing Metadata Application Profiles is an innovative reference source that discusses the latest trends and techniques for effectively managing and exchanging metadata. Including a range of perspectives on schemas and application profiles, such as interoperability, ontology-based design, and model-driven approaches, this book is ideally designed for researchers, academics, professionals, graduate students, and practitioners actively engaged in data science.

Abstract
Adenosine-to-inosine (A-to-I) RNA editing is a conserved posttranscriptional mechanism mediated by ADAR enzymes that diversifies the transcriptome by altering selected nucleotides in RNA molecules1. Although many editing sites have recently been discovered2-7, the extent to which most sites are edited and how the editing is regulated in different biological contexts are not fully understood8-10. Here we report dynamic spatiotemporal patterns and new regulators of RNA editing, discovered through an extensive profiling of A-to-I RNA editing in 8,551 human samples (representing 53 body sites from 552 individuals) from the Genotype-Tissue Expression (GTEx) project and in hundreds of other primate and mouse samples. We show that editing levels in non-repetitive coding regions vary more between tissues than editing levels in repetitive regions. Globally, ADAR1 is the primary editor of repetitive sites and ADAR2 is the primary editor of nonrepetitive coding sites, whereas the catalytically inactive ADAR3 predominantly acts as an inhibitor of editing. Cross-species analysis of RNA editing in several tissues revealed that species, rather than tissue type, is the primary determinant of editing levels, suggesting stronger cis-directed regulation of RNA editing for most sites, although the small set of conserved coding sites is under stronger trans-regulation. In addition, we curated an extensive set of ADAR1 and ADAR2 targets and showed that many editing sites display distinct tissue-specific regulation by the ADAR enzymes in vivo. Further analysis of the GTEx data revealed several potential regulators of editing, such as AIMP2, which reduces editing in muscles by enhancing the degradation of the ADAR proteins. Collectively, our work provides insights into the complex cis-and trans-regulation of A-to-I editing.

Abstract
End stage renal disease (ESRD) patients should be educated to maintain and preserve the arteriovenous fistula (AVF) in the best condition. The purpose of this work was to evaluate self-care frequency and factors that influenced such frequency. A prospective study was performed in 101 hemodialysis patients. Self-care behaviors were measured with the Scale of Assessment of Self-Care Behaviours with Arteriovenous Fistula in Hemodialysis. A regression model was used to determine the relevant predictors of self-care frequency and their influence. The incidence of self-care behaviors was 71.0%. The regression model showed that self-care behaviors were positively influenced by gender (female), ESRD etiology (hypertension, polycystic kidneys and other kidney diseases), duration of AVF and negatively by the existence of previous AVF and health professional (doctor). The frequency of self-care behaviors was lower than expected and below an appropriate standard. Education programs designed to improve self-care behaviors with AVF should be further explored in a prospective randomized trial.