Abstract

Abstract
Port wine stocks ameliorate during storage, facilitating product differentiation according to age. This induces a trade-off between immediate revenues and further maturation. Varying climate conditions in the limited supply region lead to stochastic purchase prices for wine grapes. Decision makers must integrate recurring purchasing, production, and issuance decisions. Because stocks from different age classes can be blended to create final products, the solution space increases exponentially in the number of age classes. We model the problem of managing port wine inventory as a Markov decision process, considering decay as an additional source of uncertainty. For small problems, we derive general management strategies from the long-run behavior of the optimal policy. Our solution approach for otherwise intractable large problems, therefore, first aggregates age classes to create a tractable problem representation. We then use machine learning to train tree-based decision rules that reproduce the optimal aggregated policy and the enclosed management strategies. The derived rules are scaled back to solve the original problem. Learning from the aggregated optimum outperforms benchmark rules by 21.4% in annual profits (while leaving a 2.8%-gap to an upper bound). For an industry case, we obtain a 17.4%-improvement over current practices. Our research provides distinct strategies for how producers can mitigate climate risks. The purchasing policy dynamically adapts to climate-dependent price fluctuations. Uncertainties are met with lower production of younger products, whereas strategic surpluses of older stocks ensure high production of older products. Moreover, a wide spread in the age classes used for blending reduces decay risk exposure.

Abstract

Abstract
Trigeminal somatosensory-evoked potentials (TSEPs) provide valuable insight into neural responses to oral stimuli. This study investigates TSEP recording methods and their impact on interpreting results in clinical settings to improve the development process of neurostimulation-based therapies. The experiments and results presented here aim at identifying appropriate stimulation characteristics to design an active dental prosthesis capable of contributing to restoring the lost neurosensitive connection between the teeth and the brain. Two methods of TSEP acquisition, traditional and occluded, were used, each conducted by a different volunteer. Traditional TSEP acquisition involves stimulation at different sites with varying parameters to achieve a control base. In contrast, occluded TSEPs examine responses acquired under low- and high-force bite conditions to assess the influence of periodontal mechanoreceptors and muscle activation on measurements. Traditional TSEPs demonstrated methodological feasibility with satisfactory results despite a limited subject pool. However, occluded TSEPs presented challenges in interpreting results, with responses deviating from expected norms, particularly under high force conditions, due to the simultaneous occurrence of stimulation and dental occlusion. While traditional TSEPs highlight methodological feasibility, the occluded approach highlights complexities in outcome interpretation and urges caution in clinical application. Previously unreported results were achieved, which underscores the importance of conducting further research with larger sample sizes and refined protocols in order to strengthen the reliability and validity of TSEP assessments.

Abstract
Background and Objectives: Early detection of cognitive impairment is crucial for timely clinical interventions aimed at delaying progression to dementia. However, existing screening tools are not ideal for wide population screening. This study explores the potential of combining machine learning, specifically, one-class classification, with simpler and quicker motor-cognitive tasks to improve the early detection of cognitive impairment. Methods: We gathered data on gait, fingertapping, cognitive, and dual tasks from older adults with mild cognitive impairment and healthy controls. Using one-class classification, we modeled the behavior of the majority group (healthy controls), identifying deviations from this behavior as abnormal. To account for confounding effects, we integrated confound regression into the classification pipeline. We evaluated the performance of individual tasks, as well as the combination of features (early fusion) and models (late fusion). Additionally, we compared the results with those from two-class classification and a standard cognitive screening test. Results: We analyzed data from 37 healthy controls and 16 individuals with mild cognitive impairment. Results revealed that one-class classification had higher predictive accuracy for mild cognitive impairment, whereas two-class classification performed better in identifying healthy controls. Gait features yielded the best results for one-class classification. Combining individual models led to better performance than combining features from the different tasks. Notably, the one-class majority voting approach exhibited a sensitivity of 87.5% and a specificity of 75.7%, suggesting it may serve as a potential alternative to the standard cognitive screening test. In contrast, the two-class majority voting failed to improve the low sensitivities achieved by the individual models due to the underrepresentation of the impaired group. Conclusion: Our preliminary results support the use of one-class classification with confound control to detect abnormal patterns of gait, fingertapping, cognitive, and dual tasks, to improve the early detection of cognitive impairment. Further research is necessary to substantiate the method's effectiveness in broader clinical settings.

Abstract
The growth in cloud computing, Big Data, AI and high-performance computing (HPC) necessitate the deployment of additional data centers (DC's) with high energy demands. The unprecedented increase in the Thermal Design Power (TDP) of the computing chips will require innovative cooling techniques. Furthermore, DC's are increasingly limited in their ability to add powerful GPU servers by power capacity constraints. As cooling energy use accounts for up to 40% of DC energy consumption, creative cooling solutions are urgently needed to allow deployment of additional servers, enhance sustainability and increase energy efficiency of DC's. The information in this study is provided from Start Campus' Sines facility supported by Alfa Laval for the heat exchanger and CO2 emission calculations. The study evaluates the performance and sustainability impact of various data center cooling strategies including an air-only deployment and a subsequent hybrid air/water cooling solution all utilizing sea water as the cooling source. We evaluate scenarios from 3 MW to 15+1 MW of IT load in 3 MW increments which correspond to the size of heat exchangers used in the Start Campus' modular system design. This study also evaluates the CO2 emissions compared to a conventional chiller system for all the presented scenarios. Results indicate that the effective use of the sea water cooled system combined with liquid cooled systems improve the efficiency of the DC, plays a role in decreasing the CO2 emissions and supports in achieving sustainability goals.