Abstract
Today’s society presents a fast development marked by the digital era, where the sharing, disclosure and access to information is made through information and communication technologies. The use of mobile applications is growing exponentially, spreading to the most varied social classes and everyday activity areas. Worldwide, its use in the most variety of services, has been increasing significantly. Given that, it is essential that mobile applications are accessible in a way that allows access conditions and equal opportunities to all the users. With this study we present indicators regarding the state of accessibility in mobile applications through the evaluation of five Portuguese public administration applications. The methodology used was a fully manual evaluation through a proposal of a model of evaluation divided by quantitative and qualitative requirements created by us, as well as the use of functionalities such as VoiceOver and TalkBack. Taking into account that the study initially proposed on accessibility in mobile applications is the first to be carried out in Portugal and one of the few currently worldwide, it is believed that its content may help, in some way, to raise awareness of the state of accessibility in the Portuguese mobile applications, to create measures that make these applications more accessible to all and that this work could be taken into account in future studies of the topic.

Abstract
Goal: The main goal of this research is to analyse the behaviour of a set of ten lot-sizing methods applied to different application scenarios, within the context of more traditional MRP-based manufacturing environments and on JIT/ Kanbans oriented ones. Design/Methodology/Approach: After an extended literature review, a quantitative research method is used to provide a comparative analysis on the performance of the lot-sizing methods under different simulated application scenarios, with variations in demand and peaks of seasonality. Moreover, a final summary provides the error deviations for lot-sizing methods regarding increases in demand variations and seasonality indexes. Results: The study analyses lot-sizing methods and discusses benefits and risks associated to its use in application scenarios marked by a considerable variation in demand or peaks in seasonality. Limitations of the investigation: As the application scenarios did not explore variations in the ordering and stock holding costs, further analysis including these kinds of variations is encouraged. Practical implications: The findings of this research enable the enhancement of the conscience of industrial practitioners, regarding the selection of best suited lot-sizing methods for being applied on each kind of manufacturing scenario, regarding MRP or JIT/Kanban environments. Originality/Value: Given the diversity of the existing lot-sizing methods, for instance, the heuristic ones, authors can find it quite difficult to select appropriate methods for solving their problems for each kind of application scenario. Therefore, the present study can provide useful knowledge to better support decision making in the lot-sizing domain.

Abstract
Background: Concerns about privacy and personal data protection resulted in reforms of the existing legislation in the European Union (EU). The General Data Protection Regulation (GDPR) aims to reform the existing directive on the topic of personal data protection of EU citizens with a strong emphasis on more control of the citizens over their data and in the establishment of rules for the processing of personal data. OpenEHR is a standard that embodies many principles of interoperable and secure software for electronic health records (EHRs) and has been advocated as the best approach for the development of hospital information systems. Objective: This study aimed to understand to what extent the openEHR standard can help in the compliance of EHR systems to the GDPR requirements. Methods: A list of requirements for an EHR to support GDPR compliance and also a list of the openEHR design principles were made. The requirements were categorized and compared with the principles by experts on openEHR and GDPR. Results: A total of 50 GDPR requirements and 8 openEHR design principles were identified. The openEHR principles conformed to 30% (15/50) of GDPR requirements. All the openEHR principles were aligned with GDPR requirements. Conclusions: This study showed that the openEHR principles conform well to GDPR, underlining the common wisdom that truly realizing security and privacy requires it to be built in from the start. By using an openEHR-based EHR, the institutions are closer to becoming compliant with GDPR while safeguarding the medical data.

Abstract
We fit an immune response model to data reporting the CD4(+) T cell numbers from the 28 days following the infection of mice with lymphocytic choriomeningitis virus LCMV. We used an ODE model that was previously used to describe qualitatively the behaviour of CD4(+) T cells, regulatory T cells (Tregs) and interleukine-2 (IL-2) density. The model considered two clonotypes of T cells in order to fit simultaneously the two time series for the gp61 and NP309 epitopes. We observed the proliferation of T cells and, to a lower extent, Tregs during the immune activation phase following infection and subsequently, during the contraction phase, a smooth transition from faster to slower death rates. The six parameters that were optimized were: the beginning and ending times of the immune response, the growth rate of T cells, their capacity, and the two related with the homeostatic numbers of T cells that respond to each epitope. We showed that the ODE model was able to be calibrated thus providing a quantitative description of the data.

Abstract

Abstract
Audiovisual didactic content has been in recent years disseminated, in the Physics domain, mainly through YouTube platform. Many aspects of video production activities can increase students' selfesteem, increase their satisfaction with the learning experience, promote a positive attitude towards the subject, provide weaker students with a broad individual tutoring, encouraging students to discuss with each other, exchange their opinions, and compare the results of lab activities. On the other hand, video can support research activities, offering the researcher access to a rich data aggregation to investigate the learning processes. The main objective of this study is to understand the use of online tools in the context of teaching, for this we make a correlation between studies using audiovisual resources in the study of Physics, and our testbed with an online video annotation tool. Results show that students expressed a gain from oral lectures and access to new sources of learning.