2020
Autores
Ferreira, MC; Dias, TG; Falcão e Cunha, J;
Publicação
International Journal of Smart Sensor Technologies and Applications
Abstract
2020
Autores
Lorenz, J; Silva, MI; Aparício, D; Ascensão, JT; Bizarro, P;
Publicação
ICAIF '20: The First ACM International Conference on AI in Finance, New York, NY, USA, October 15-16, 2020
Abstract
2020
Autores
Saraiva, AA; Santos, DBS; Pedro, P; Sousa, JVM; Ferreira, NMF; Neto, JESB; Soares, S; Valente, A;
Publicação
PROCEEDINGS OF THE 13TH INTERNATIONAL JOINT CONFERENCE ON BIOMEDICAL ENGINEERING SYSTEMS AND TECHNOLOGIES, VOL 3: BIOINFORMATICS
Abstract
This article describes a classification model of optical coherence tomography images using convolution neural network. The dataset used was the Labeled Optical Coherence Tomography provided by (Kermany et al., 2018) with a total of 84495 images, with 4 classes: normal, drusen, diabetic macular edema and choroidal neovascularization. To evaluate the generalization capacity of the models k-fold cross-validation was used. The classification models were shown to be efficient, and as a result an average accuracy of 94.35% was obtained.
2020
Autores
Alves, LQ; Ruivo, R; Fonseca, MM; Lopes Marques, M; Ribeiro, P; Castro, LFC;
Publicação
NUCLEIC ACIDS RESEARCH
Abstract
The rapid expansion of high-quality genome assemblies, exemplified by ongoing initiatives such as the Genome-10K and i5k, demands novel automated methods to approach comparative genomics. Of these, the study of inactivating mutations in the coding region of genes, or pseudogenization, as a source of evolutionary novelty is mostly overlooked. Thus, to address such evolutionary/genomic events, a systematic, accurate and computationally automated approach is required. Here, we present PseudoChecker, the first integrated online platform for gene inactivation inference. Unlike the few existing methods, our comparative genomics-based approach displays full automation, a built-in graphical user interface and a novel index, PseudoIndex, for an empirical evaluation of the gene coding status. As a multi-platform online service, PseudoChecker simplifies access and usability, allowing a fast identification of disruptive mutations. An analysis of 30 genes previously reported to be eroded in mammals, and 30 viable genes from the same lineages, demonstrated that PseudoChecker was able to correctly infer 97% of loss events and 95% of functional genes, confirming its reliability. PseudoChecker is freely available, without login required, at http://pseudochecker.ciimar.up.pt.
2020
Autores
Fernandes, S; Restivo, A; Ferreira, HS; Aguiar, A;
Publicação
Programming
Abstract
With the increasing complexity of software systems, software developers would benefit from instant and continuous feedback about the system they are maintaining and evolving. Despite existing several solutions providing feedback and suggesting improvements, many tools require explicit invocations, leading developers to miss some improvement opportunities, such as important refactorings, due to the loss of their train of thought. Therefore, to address these limitations, we developed a Visual Studio Code plugin providing real-time feedback - - and also information about each commit made to the version control system. This tool is also capable of recommending two types of refactorings. To validate this approach, we did a preliminary controlled experiment using hypothesis-tests to check specific results. However, in this initial stage, we didn't have enough data to confirm our research questions, and we weren't able yet to confirm the main hypothesis.
2020
Autores
Carrera, I; Dutra, I; Tejera, E;
Publicação
BCB
Abstract
A main problem for predicting cell line interactions with chemical compounds is the lack of a computational representation for cell lines. We describe a method for characterizing cell lines from scientific literature. We retrieve and process cell line-related scientific papers, perform a document classification algorithm, and then obtain a description of the information space of each cell line. We have successfully characterized a set of 300+ cell lines.
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