Abstract

Abstract
Fabry disease (FD) is a rare disease commonly complicated with white matter lesions (WMLs). WMLs, which have extensively been associated with gait impairment, justify further investigation of its implication in FD. This study aims to identify a set of gait characteristics to discriminate FD patients with/without WMLs and healthy controls. Seventy-six subjects walked through a predefined circuit using gait sensors that continuously acquired different stride features. Data were normalized using multiple regression normalization taking into account the subject physical properties, with the assessment of 32 kinematic gait variables. A filter method (Mann Whitney U test and Pearson correlation) followed by a wrapper method (recursive feature elimination (RFE) for Logistic Regression (LR) and Support Vector Machine (SVM) and information gain for Random Forest (RF)) were used for feature selection. Then, five different classifiers (LR, SVM Linear and RBF kernel, RF, and K-Nearest Neighbors (KNN)) based on different selected set features were evaluated. For FD patients with WMLs versus controls the highest accuracy of 72% was obtained using LR based on 3 gait variables: pushing, foot flat, and maximum toe clearance 2. For FD patients without WMLs versus controls, the best performance was observed using LR and SVM RBF kernel based on loading, foot flat, minimum toe clearance, stride length variability, loading variability, and lift-off angle variability with an accuracy of 83%. These findings are the first step to demonstrate the potential of machine learning techniques based on gait variables as a complementary tool to understand the role of WMLs in the gait impairment of FD.

Abstract
Breast cancer image fusion consists of registering and visualizing different sets of a patient synchronized torso and radiological images into a 3D model. Breast spatial interpretation and visualization by the treating physician can be augmented with a patient-specific digital breast model that integrates radiological images. But the absence of a ground truth for a good correlation between surface and radiological information has impaired the development of potential clinical applications. A new image acquisition protocol was designed to acquire breast Magnetic Resonance Imaging (MRI) and 3D surface scan data with surface markers on the patient's breasts and torso. A patient-specific digital breast model integrating the real breast torso and the tumor location was created and validated with a MRI/3D surface scan fusion algorithm in 16 breast cancer patients. This protocol was used to quantify breast shape differences between different modalities, and to measure the target registration error of several variants of the MRI/3D scan fusion algorithm. The fusion of single breasts without the biomechanical model of pose transformation had acceptable registration errors and accurate tumor locations. The performance of the fusion algorithm was not affected by breast volume. Further research and virtual clinical interfaces could lead to fast integration of this fusion technology into clinical practice. (C) 2020 The Authors. Published by Elsevier Ltd.

Abstract

Abstract
After the computational thinking sessions in the previous 2016-2019 editions of TEEM Conference, the fifth edition of this track has been organized in the current 2020 edition. Computational thinking is still a very significant topic, especially, but not only, in pre-university education. In this edition, the robotic has a special role in the track, with a strength relationship with the STEM and STEAM education of children at the pre-university levels, seeding the future of our society. © 2020 ACM.

Abstract
People with visual impairments generally experience many barriers when visiting museum exhibitions, given the ocular centricity of these institutions. The situation is worsened by a frequent lack of physical, intellectual and sensory access to exhibits or replicas, increased by the inaccessibility to use ICT-based local or general alternative or augmentative communication resources that can allow different interactions to sighted visitors. Few studies analyze applications of assistive technologies for multisensory exhibit design and relate them with visitors’ experiences. This article aims to contribute to the field of accessibility in museums by providing an overview of the experiences and expectations of blind and visually impaired patrons when visiting those places, based on a literature review. It also surveys assistive technologies used to enhance the experiences of visitors with vision loss while visiting museum exhibitions and spaces. From this, it is highlighted that adopting hybrid technological approaches, following universal design principles and collaborating with blind and visually impaired people, can contribute to integrate access across the continuum of visits. © Common Ground Research Networks, Roberto Vaz, Diamantino Freitas, António Coelho, Some Rights Reserved,