Abstract
Human mobility patterns are associated with many aspects of our life. With the increase of the popularity and pervasiveness of smartphones and portable devices, the Internet of Things (IoT) is turning into a permanent part of our daily routines. Positioning technologies that serve these devices such as the cellular antenna (GSM networks), global navigation satellite systems (GPS), and more recently the WiFi positioning system (WPS) provide large amounts of spatio-temporal data in a continuous way (data streams). In order to understand human behavior, the detection of important places and the movements between these places is a fundamental task. That said, the proposal of this work is a method for discovering user habits over mobility data without any a priori or external knowledge. Our approach extends a density-based clustering method for spatio-temporal data to identify meaningful places the individuals' visit. On top of that, a Gaussian mixture model (GMM) is employed over movements between the visits to automatically separate the trajectories accordingly to their key identifiers that may help describe a habit. By regrouping trajectories that look alike by day of the week, length, and starting hour, we discover the individual's habits. The evaluation of the proposed method is made over three real-world datasets. One dataset contains high-density GPS data and the others use GSM mobile phone data with 15-min sampling rate and Google Location History data with a variable sampling rate. The results show that the proposed pipeline is suitable for this task as other habits rather than just going from home to work and vice versa were found. This method can be used for understanding person behavior and creating their profiles revealing a panorama of human mobility patterns from raw mobility data.

Abstract

Abstract
In this article, we focus on the acceleration of a chemical reaction simulation that relies on a system of stiff ordinary differential equation (ODEs) targeting heterogeneous computing systems with CPUs and field-programmable gate arrays (FPGAs). Specifically, we target an essential kernel of the coupled chemistry aerosol-tracer transport model to the Brazilian developments on the regional atmospheric modeling system (CCATT-BRAMS). We focus on a linear solve step using the QR factorization based on the modified Gram-Schmidt method as the basis of the ODE solver in this application. We target Intel hardware accelerator research program (HARP) architecture with the OpenCL programming environment for these early experiments. Our design exploration reveals a hardware design that is up to 4 times faster than the original iterative Jacobi method used in this solver. Still, even with hardware support, the overall performance of our QR-based hardware is lower than its original software version.

Abstract
Background: The clinical decision-making process in pressure ulcer management is complex, and its quality depends on both the nurse's experience and the availability of scientific knowledge. This process should follow evidence-based practices incorporating health information technologies to assist health care professionals, such as the use of clinical decision support systems. These systems, in addition to increasing the quality of care provided, can reduce errors and costs in health care. However, the widespread use of clinical decision support systems still has limited evidence, indicating the need to identify and evaluate its effects on nursing clinical practice. Objective: The goal of the review was to identify the effects of nurses using clinical decision support systems on clinical decision making for pressure ulcer management. Methods: The systematic review was conducted in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) recommendations. The search was conducted in April 2019 on 5 electronic databases: MEDLINE, SCOPUS, Web of Science, Cochrane, and CINAHL, without publication date or study design restrictions. Articles that addressed the use of computerized clinical decision support systems in pressure ulcer care applied in clinical practice were included. The reference lists of eligible articles were searched manually. The Mixed Methods Appraisal Tool was used to assess the methodological quality of the studies. Results: The search strategy resulted in 998 articles, 16 of which were included. The year of publication ranged from 1995 to 2017, with 45% of studies conducted in the United States. Most addressed the use of clinical decision support systems by nurses in pressure ulcers prevention in inpatient units. All studies described knowledge-based systems that assessed the effects on clinical decision making, clinical effects secondary to clinical decision support system use, or factors that influenced the use or intention to use clinical decision support systems by health professionals and the success of their implementation in nursing practice. Conclusions: The evidence in the available literature about the effects of clinical decision support systems (used by nurses) on decision making for pressure ulcer prevention and treatment is still insufficient. No significant effects were found on nurses' knowledge following the integration of clinical decision support systems into the workflow, with assessments made for a brief period of up to 6 months. Clinical effects, such as outcomes in the incidence and prevalence of pressure ulcers, remain limited in the studies, and most found clinically but nonstatistically significant results in decreasing pressure ulcers. It is necessary to carry out studies that prioritize better adoption and interaction of nurses with clinical decision support systems, as well as studies with a representative sample of health care professionals, randomized study designs, and application of assessment instruments appropriate to the professional and institutional profile. In addition, long-term follow-up is necessary to assess the effects of clinical decision support systems that can demonstrate a more real, measurable, and significant effect on clinical decision making.

Abstract

Abstract
Optical clearing (OC) opens new possibilities in enhancement of optical diagnostics of tumors. This chapter discusses different approaches for discrimination of healthy and malignant tissues using OC. The OC-assisted optical imaging techniques allow for acquiring high-resolution structural and functional images of neoplasms and their microvasculature. The study of the OC mechanisms in both normal and pathologically modified tissues provides differentiated results that allow for recognizing pathology. Both high water content and high cell density in tumors result in differences in diffusion rate of optical clearing agents (OCAs) in normal tissue and tumor. The monitoring of OCA diffusion in tissues with high temporal and depth resolution allows one to differentiate healthy from malignant tissues. Evaluation of protein dissociation during OC treatments may also help for discrimination between normal and pathological tissues.