Abstract
Electrical energy consumption pattern has always been important for power distribution companies, because load variations and method of electricity consumption affect energy losses amount. For this, distribution companies frequently encourage the network users to correct their energy consumption behavior by suggesting some incentives. Reconfiguration of distribution systems for a specific load pattern is an effective way to reduce the losses. Hence, some papers have considered load variations in distribution system reconfiguration (DSR) to show importance of consumption pattern for reconfiguration decisions. However, most of specialized studies have been ignored load changes in their reconfiguration models because of a significant increase in computational burden and processing time. On the other hand, neglecting the consumption pattern causes the energy losses is calculated inaccurately. Therefore, this paper intends to evaluate effect of load pattern on reconfiguration plans in order to find out importance of considering load variations in energy losses minimization via DSR. The analysis has been conducted on well-known distribution systems by AMPL (a classic optimization tool).

Abstract
Objectives: This study evaluated the usefulness of artificial intelligence (AI) algorithms as tools in improving the accuracy of histologic classification of breast tissue. Methods: Overall, 100 microscopic photographs (test A) and 152 regions of interest in whole-slide images (test B) of breast tissue were classified into 4 classes: normal, benign, carcinoma in situ (CIS), and invasive carcinoma. The accuracy of 4 pathologists and 3 pathology residents were evaluated without and with the assistance of algorithms. Results: In test A, algorithm A had accuracy of 0.87, with the lowest accuracy in the benign class (0.72). The observers had average accuracy of 0.80, and most clinically relevant discordances occurred in distinguishing benign from CIS (7.1% of classcations). With the assistance of algorithm A, the observers significantly increased their average accuracy to 0.88. In test B, algorithm B had accuracy of 0.49, with the lowest accuracy in the CIS class (0.06). Me observers had average accuracy of 0.86, and most clinically relevant discordances occurred in distinguishing benign from CIS (6.3% of classifications). With the assistance of algorithm B, the observers maintained their average accuracy. Conclusions: AI tools can increase the classification accuracy of pathologists in the setting of breast lesions.

Abstract

Abstract
Lower limb amputation is a condition affecting millions of people worldwide. Patients are often prescribed with lower limb prostheses to aid their mobility, but these prostheses require frequent adjustments through an iterative and manual process, which heavily depends on patient feedback and on the prosthetist's experience. New computer-aided design and manufacturing technologies have been emerging as a way to improve the fitting process by creating virtual socket models. Statistical Shape modelling was used to create 3D models of transtibial (TT) and transfemoral (TF) sockets. Their generalization errors were, respectively, 6.8 +/- 1.8 mm and 10.5 +/- 1.6 mm, while specificity errors were 9.7 +/- 0.6 mm and 9.8 +/- 0.2 mm. In both models, a visual analysis showed that biomechanically meaningful features were captured: the largest variations found for both types were in the length of the residual limb and in the perimeter variation along the limb. The results obtained proved that statistical shape modelling methods can be applied to TF and TT sockets, with several potential applications in the orthoprosthetic field: generation of new plausible shapes and on-demand socket design adjustments.

Abstract
Statistics have demonstrated that one of the main factors responsible for the high mortality rate related to lung cancer is the late diagnosis. Precision medicine practices have shown advances in the individualized treatment according to the genetic profile of each patient, providing better control on cancer response. Medical imaging offers valuable information with an extensive perspective of the cancer, opening opportunities to explore the imaging manifestations associated with the tumor genotype in a non-invasive way. This work aims to study the relevance of physiological features captured from Computed Tomography images, using three different 2D regions of interest to assess the Epidermal growth factor receptor (EGFR) mutation status: nodule, lung containing the main nodule, and both lungs. A Convolutional Autoencoder was developed for the reconstruction of the input image. Thereafter, the encoder block was used as a feature extractor, stacking a classifier on top to assess the EGFR mutation status. Results showed that extending the analysis beyond the local nodule allowed the capture of more relevant information, suggesting the presence of useful biomarkers using the lung with nodule region of interest, which allowed to obtain the best prediction ability. This comparative study represents an innovative approach for gene mutations status assessment, contributing to the discussion on the extent of pathological phenomena associated with cancer development, and its contribution to more accurate Artificial Intelligence-based solutions, and constituting, to the best of our knowledge, the first deep learning approach that explores a comprehensive analysis for the EGFR mutation status classification.

Abstract
We report the first findings of an empirical study aimed at investigating how COVID-19 pandemic has impacted the work practices and lifestyles of digital nomads (DN). To do this, we analyzed messages, questions and comments posted by digital nomads in a specific online discussion community of the Reddit social network. Preliminary findings indicate COVID-19 as an opportunity to test DN lifestyle by aspiring digital nomads who want to plan their careers and also present evidence of an overload of online channels for actual DNs. On the other hand, we found that much of the literature on digital nomadism is fragmented and scattered through different disciplines and perspectives, with a strong focus on digital nomads' lifestyles. In order to obtain a holistic and unified understanding of digital nomads, we conducted a comprehensive literature review to further conceptualize the phenomenon under study.