Abstract
The evolution of personalized medicine has changed the therapeutic strategy from classical chemotherapy and radiotherapy to a genetic modification targeted therapy, and although biopsy is the traditional method to genetically characterize lung cancer tumor, it is an invasive and painful procedure for the patient. Nodule image features extracted from computed tomography (CT) scans have been used to create machine learning models that predict gene mutation status in a noninvasive, fast, and easy-to-use manner. However, recent studies have shown that radiomic features extracted from an extended region of interest (ROI) beyond the tumor, might be more relevant to predict the mutation status in lung cancer, and consequently may be used to significantly decrease the mortality rate of patients battling this condition. In this work, we investigated the relation between image phenotypes and the mutation status of Epidermal Growth Factor Receptor (EGFR), the most frequently mutated gene in lung cancer with several approved targeted-therapies, using radiomic features extracted from the lung containing the nodule. A variety of linear, nonlinear, and ensemble predictive classification models, along with several feature selection methods, were used to classify the binary outcome of wild-type or mutant EGFR mutation status. The results show that a comprehensive approach using a ROI that included the lung with nodule can capture relevant information and successfully predict the EGFR mutation status with increased performance compared to local nodule analyses. Linear Support Vector Machine, Elastic Net, and Logistic Regression, combined with the Principal Component Analysis feature selection method implemented with 70% of variance in the feature set, were the best-performing classifiers, reaching Area Under the Curve (AUC) values ranging from 0.725 to 0.737. This approach that exploits a holistic analysis indicates that information from more extensive regions of the lung containing the nodule allows a more complete lung cancer characterization and should be considered in future radiogenomic studies.

Abstract
How difficult is it to compute the communication complexity of a two-argument total Boolean function f : [N] × [N] ? {0, 1}, when it is given as an N × N binary matrix? In 2009, Kushilevitz and Weinreb showed that this problem is cryptographically hard, but it is still open whether it is NP-hard. In this work, we show that it is NP-hard to approximate the size (number of leaves) of the smallest constant-round protocol for a two-argument total Boolean function f : [N] × [N] ? {0, 1}, when it is given as an N × N binary matrix. Along the way to proving this, we show a new deterministic variant of the round elimination lemma, which may be of independent interest. © Shuichi Hirahara, Rahul Ilango, and Bruno Loff; licensed under Creative Commons License CC-BY 4.0

Abstract
LightGBM has proven to be an effective forecasting algorithm by winning the M5 forecasting competition. However, given the sensitivity of LightGBM to hyperparameters, it is likely that their default values are not optimal. This work aims to answer whether it is essential to tune the hyperparameters of LightGBM to obtain better accuracy in time series forecasting and whether it can be done efficiently. Our experiments consisted of the collection and processing of data as well as hyperparameters generation and finally testing. We observed that on the 58 time series tested, the mean squared error is reduced by a maximum of 17.45% when using randomly generated configurations in contrast to using the default one. Additionally, the study of the individual hyperparameters’ performance was done. Based on the results obtained, we propose an alternative set of default LightGBM hyperparameter values to be used whilst using time series data for forecasting.

Abstract
Electric forklifts are extremely important for the world's logistics and industry. Lead acid batteries are the most common energy storage system for electric forklifts; however, to ensure more energy efficiency and less environmental pollution, they are starting to use lithium batteries. All lithium batteries need a battery management system (BMS) for safety, long life cycle and better efficiency. This system is capable to estimate the battery state of charge, state of health and state of function, but those cannot be measured directly and must be estimated indirectly using battery models. Consequently, accurate battery models are essential for implementation of advance BMS and enhance its accuracy. This work presents a comparison between four different models, four different types of optimizers algorithms and seven different experiment designs. The purpose is defining the best model, with the best optimizer, and the best experiment design for battery parameter estimation. This best model is intended for a state of charge estimation on a battery applied on an electric forklift. The nonlinear grey box model with the nonlinear least square method presented a better result for this purpose. This model was estimated with the best experiment design which was defined considering the fit to validation data, the parameter standard deviation and the output variance. With this approach, it was possible to reach more than 80% of fit in different validation data, a non-biased and little prediction error and a good one-step ahead result.

Abstract

Abstract
Due to the competitiveness in the job shop nature of the metalworking industry, project management plays an important role in improving performance, efficiently and effectively managing its performance. Many of the generic problems observed in project management in metalworking industries were in the domain of document management, communication, multiple projects simultaneously, organizational structure, and poorly time estimation of project activities. The aim of this study was to improve the planning and time control in the project management of a metalworking industry in order to reduce the delivery delays. Using the existing data, an analysis of the project management process was carried out with the view to optimize the production system. In order to meet the established objectives, some of the project management tools were used, such as the Ishikawa diagram, PERT (three points estimating times), Monte Carlo simulation, as well as the involvement of people in the estimation and sequencing of activities, and holding weekly meetings to ensure the alignment of professionals. After the implementation of the actions proposed for the production process, there were gains of 50% and 38% in the average of deviations of times for two different projects of the case study and the Monte Carlo gave the best approximation.