Abstract
Purpose 2-[F-18]FDG PET/CT plays an important role in the management of pulmonary nodules. Convolutional neural networks (CNNs) automatically learn features from images and have the potential to improve the discrimination between malignant and benign pulmonary nodules. The purpose of this study was to develop and validate a CNN model for classification of pulmonary nodules from 2-[F-18]FDG PET images.Methods One hundred thirteen participants were retrospectively selected. One nodule per participant. The 2-[F-18]FDG PET images were preprocessed and annotated with the reference standard. The deep learning experiment entailed random data splitting in five sets. A test set was held out for evaluation of the final model. Four-fold cross-validation was performed from the remaining sets for training and evaluating a set of candidate models and for selecting the final model. Models of three types of 3D CNNs architectures were trained from random weight initialization (Stacked 3D CNN, VGG-like and Inception-v2-like models) both in original and augmented datasets. Transfer learning, from ImageNet with ResNet-50, was also used.Results The final model (Stacked 3D CNN model) obtained an area under the ROC curve of 0.8385 (95% CI: 0.6455-1.0000) in the test set. The model had a sensibility of 80.00%, a specificity of 69.23% and an accuracy of 73.91%, in the test set, for an optimised decision threshold that assigns a higher cost to false negatives.Conclusion A 3D CNN model was effective at distinguishing benign from malignant pulmonary nodules in 2-[F-18]FDG PET images.

Abstract
The development of accurate methods for OCT image analysis is highly dependent on the availability of large annotated datasets. As such datasets are usually expensive and hard to obtain, novel approaches based on deep generative models have been proposed for data augmentation. In this work, a flow-based network (SRFlow) and a generative adversarial network (ESRGAN) are used for synthesizing high-resolution OCT B-scans from low-resolution versions of real OCT images. The quality of the images generated by the two models is assessed using two standard fidelity-oriented metrics and a learned perceptual quality metric. The performance of two classification models trained on real and synthetic images is also evaluated. The obtained results show that the images generated by SRFlow preserve higher fidelity to the ground truth, while the outputs of ESRGAN present, on average, better perceptual quality. Independently of the architecture of the network chosen to classify the OCT B-scans, the model's performance always improves when images generated by SRFlow are included in the training set.

Abstract
Pulse oximeters are medical devices used to assess peripheral arterial oxygen saturation (SpO(2)) noninvasively. In contrast, the gold standard requires arterial blood to be drawn to measure the arterial oxygen saturation (SaO(2)). Devices currently on the market measure SpO(2) with lower accuracy in populations with darker skin tones. Pulse oximetry inaccuracies can yield episodes of hidden hypoxemia (HH), with SpO(2) >= 88%, but SaO(2) < 88%. HH can result in less treatment and increased mortality. Despite being flawed, pulse oximeters remain ubiquitously used; debiasing models could alleviate the downstream repercussions of HH. To our knowledge, this is the first study to propose such models. Experiments were conducted using the MIMIC-IV dataset. The cohort includes patients admitted to the Intensive Care Unit with paired (SaO(2), SpO(2)) measurements captured within 10min of each other. We built a XGBoost regression predicting SaO(2) from SpO(2), patient demographics, physiological data, and treatment information. We used an asymmetric mean squared error as the loss function to minimize falsely elevated predicted values. The model achieved R-2 = 67.6% among Black patients; frequency of HH episodes was partially mitigated. Respiratory function was most predictive of SaO(2); race-ethnicity was not a top predictor. This singlecenter study shows that SpO(2) corrections can be achieved with Machine Learning. In future, model validation will be performed on additional patient cohorts featuring diverse settings.

Abstract
BackgroundBreast cancer therapy improved significantly, allowing for different surgical approaches for the same disease stage, therefore offering patients different aesthetic outcomes with similar locoregional control. The purpose of the CINDERELLA trial is to evaluate an artificial-intelligence (AI) cloud-based platform (CINDERELLA platform) vs the standard approach for patient education prior to therapy. MethodsA prospective randomized international multicentre trial comparing two methods for patient education prior to therapy. After institutional ethics approval and a written informed consent, patients planned for locoregional treatment will be randomized to the intervention (CINDERELLA platform) or controls. The patients in the intervention arm will use the newly designed web-application (CINDERELLA platform, CINDERELLA APProach) to access the information related to surgery and/or radiotherapy. Using an AI system, the platform will provide the patient with a picture of her own aesthetic outcome resulting from the surgical procedure she chooses, and an objective evaluation of this aesthetic outcome (e.g., good/fair). The control group will have access to the standard approach. The primary objectives of the trial will be i) to examine the differences between the treatment arms with regards to patients' pre-treatment expectations and the final aesthetic outcomes and ii) in the experimental arm only, the agreement of the pre-treatment AI-evaluation (output) and patient's post-therapy self-evaluation. DiscussionThe project aims to develop an easy-to-use cost-effective AI-powered tool that improves shared decision-making processes. We assume that the CINDERELLA APProach will lead to higher satisfaction, better psychosocial status, and wellbeing of breast cancer patients, and reduce the need for additional surgeries to improve aesthetic outcome.

Abstract
Morphing attacks keep threatening biometric systems, especially face recognition systems. Over time they have become simpler to perform and more realistic, as such, the usage of deep learning systems to detect these attacks has grown. At the same time, there is a constant concern regarding the lack of interpretability of deep learning models. Balancing performance and interpretability has been a difficult task for scientists. However, by leveraging domain information and proving some constraints, we have been able to develop IDistill, an interpretable method with state-of-the-art performance that provides information on both the identity separation on morph samples and their contribution to the final prediction. The domain information is learnt by an autoencoder and distilled to a classifier system in order to teach it to separate identity information. When compared to other methods in the literature it outperforms them in three out of five databases and is competitive in the remaining.

Abstract
The preservation of many music works produced in the past entails their digitalization and consequent accessibility in an easy-to-manage digital format. Carrying this task manually is very time consuming and error prone. While optical music recognition systems usually perform well on printed scores, the processing of handwritten musical scores by computers remain far from ideal. One of the fundamental stages to carry out this task is the staff line detection. In this paper a new method for the automatic detection of music staff lines based on a connected path approach is presented. Lines affected by curvature, discontinuities, and inclination are robustly detected. Experimental results show that the proposed technique consistently outperforms well-established algorithms.