Abstract
Car rental and car sharing are two established mobility concepts which traditionally have been offered by specialized providers. Presumably to increase utilization and profitability, most recently, car rental providers began to offer car sharing in addition, and vice versa. To assess and quantify benefits and drawbacks of combining both into a single mobility concept with one common fleet, we consider such combined systems on an aggregate level, replicating demand patterns and rentals throughout a typical week. Our systematic approach reflects that, depending on a provider's status quo, different business practices exist, for example with regard to the applied revenue management approaches. Methodologically, our analyses base on mathematical optimization. We propose several models that consider the different business practices and degrees to which the respective new mobility concept is offered. To support mobility providers in their strategic decision-making, we derive managerial insights based on numerical studies that use real-life data.

Abstract
In the energy production sector, increasing the quantity and efficiency of renewable energies, such as hydropower plants, is crucial to mitigate climate change. This paper proposes a new and flexible model for optimising operational decisions in watershed systems with interconnected dams. We propose a systematic representation of watersheds by a network of different connection points, which is the basis for an efficient Mixed-Integer Linear Programming model. The model is designed to be adaptable to different connections between dams in both main and tributary rivers. It supports decisions on power generation, pumping and water discharge, maximising profit, and considering realistic constraints on water use and factors such as future energy prices and weather conditions. A relax-and-fix heuristic is proposed to solve the model, along with two heuristic variants to accommodate different watershed structures and sizes. Methodological tests with simulated instances validate their performance, with both variants achieving results within 1% of the optimal solution faster than the model for the tested instances. To evaluate the performance of the approaches in a real-world scenario, we analyse the case study of the C & aacute;vado watershed (Portugal), providing relevant insights for managing dam operations. The model generally follows the actual decisions made in typical situations and flood scenarios. However, in the case of droughts, it tends to be more conservative, saving water unless necessary or profitable. The model can be used in a decision-support system to provide decision-makers with an integrated view of the entire watershed and optimised solutions to the operational problem at hand.

Abstract
Warehouses and distribution centres play a key role in any Supply Chain, particularly in the retail sector, where a network of stores needs to be replenished in a highly dynamic and increasingly uncertain context. In this regard, companies need to improve their intralogistics systems daily to ensure long-term competitiveness and sustainable growth. This is especially true in picking-by-line systems where many time-consuming and manual tasks are usually involved. This study introduces a new decision support tool based on simulation methods to aid the decision-making process in a picking-by-Line system, aimed to improve the overall picking operations efficiency, through human-centric perspective. A Discrete-Event-Simulation model is proposed to assess a set of parameters under several scenarios, driving a more informed decision-making process towards cost-effective strategies. The proposed approach was validated through an empirical case study showing its effectiveness in assisting operational planning decisions related to capacity and resource allocation. The system demonstrates promising versatility for application across varied warehouse environments. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2024.

Abstract
In this work a hybrid simulation-optimization approach is presented to support decision-making towards improved resiliency and sustainability in pharmaceutical supply chain (PSC) operations. In a first step, a simulation model is used to assess the PSC performance under a set of disruptive scenarios to select the best inventory-based strategy for enhanced resiliency. Disruptions addressed in this work are mainly related to unpredicted medium-term production stoppages due to unexpected high-impact events such as accidents in production and transportation, or natural disasters. In a second step, a multi-objective mixed integer linear programming (MO-MILP) model is developed to optimize the selected inventory-based strategy regarding the economic, social, and environmental dimensions. In particular, the social and environmental aspects are introduced by anticipating the expected waste generation of close to expire medicines, redirecting them into a donation scheme. The proposed approach is applied to a representative PSC, with preliminary results showing the relevance of this tool for decision-makers to assess the trade-offs associated to the economic and social dimensions, as well as their impacts on waste generation.

Abstract
Background: In many urban areas, 80% to 90% of pollutant emissions are generated by road traffic, particularly from heavy vehicles. With the anticipated surge in e-commerce logistics, the need for effective urban mobility control measures has become urgent, focusing on traffic restrictions and efficient enforcement tools. This work introduces Log-ON, a multi-stakeholder information system designed to facilitate the implementation and management of sustainable traffic restrictions. Methods: The proposed system was developed through extensive literature reviews, expert consultations, and feedback from logistics fleet managers. User-centered mock-ups were created for various stakeholders, including the public, regulatory authorities, logistics operators, and enforcement agencies, ensuring that the system effectively addresses a diverse set of needs. Results: By taking into account a wide range of influencing factors, Log-ON functions as a decision-support tool designed to optimize access restrictions for vehicles, particularly heavy vehicles, in urban environments. Conclusions: Log-ON's adoption promises significant improvements in urban mobility by reducing traffic-related pollution and fostering healthier, cleaner cities. However, traffic restrictions could increase delivery costs, potentially disrupting logistics operations. To address this, the development of new business models for last-mile delivery is essential, ensuring that sustainable traffic management strategies align with the economic challenges faced by logistics providers.

Abstract
Natural gas (NG) is commonly used in kitchens, powering stoves, ovens, and other appliances. While it is known for its efficiency and convenience, NG contributes to the release of nitrogen dioxide (NO2) and can have significant implications for human health. In this study, the importance of the use of NG in kitchens on human exposure to NO2 was analyzed. An extensive literature review in the field was conducted, and the NO2 levels were assessed in kitchens with NG cookers in Aveiro and electric cookers in Porto, both in Portugal. Higher levels of NO2 were found in kitchens in Aveiro, where NO2 levels outdoors are lower than in Porto. This pollutant can spread to other rooms, especially when ventilation is lacking, which is particularly concerning during colder seasons and at night. As around 70% of the time is spent at home, this can have a significant impact on human exposure to NO2. Therefore, although Aveiro has low levels of NO2 outdoors, its population may be exposed to much higher levels of this pollutant than the Porto population, a city with air quality issues, but predominantly using electric cookers. This finding emphasizes the need for the stricter regulation of NG use indoors to protect human health and also suggests a shift in human health protection policies from mere monitoring/control of outdoor air quality to a comprehensive assessment of human exposure, including exposure to indoor air quality.