Abstract
An increasing area of study for economists and sociologists is the varying organizational structures between business networks. The use of network science makes it possible to identify the determinants of the performance of these business networks. In this work we look for the determinants of inter-firm performance. On one hand, a new method of supervised clustering with attributed networks is proposed, SUWAN, with the aim at obtaining class-uniform clusters of the turnover, while minimizing the number of clusters. This method deals with representative-based supervised clustering, where a set of initial representatives is randomly chosen. One of the innovative aspects of SUWAN is that we use a supervised clustering algorithm to attributed networks that can be accomplished through a combination of weights between the matrix of distances of nodes and their attributes when defining the clusters. As a benchmark, we use Subgroup Discovery on attributed network data. Subgroup Discovery focuses on detecting subgroups described by specific patterns that are interesting with respect to some target concept and a set of explaining features. On the other hand, in order to analyze the impact of the network's topology on the group's performance, some network topology measures, and the group total turnover were exploited. The proposed methodologies are applied to an inter-organizational network, the EuroGroups Register, a central register that contains statistical information on business networks from European countries.

Abstract
Sponsored advertising on search engines is one of the fastest growing online advertising marketplaces. The space available for paid ads, or positions, is sold using auctions and payment is calculated considering the number of clicks each position receives. Two mechanisms are generally used in position auctions: Generalized Second Price (GSP) (e.g. Google, Yahoo!) and Vickrey-Clarke-Groves (VCG) (e.g. Facebook). To understand which mechanism guarantees the highest payoff to market players (search engines and advertisers), a multi-agent simulation is developed in Netlogo. Using the generated data, a supervised learning-based analysis on search engines and bidders' payoffs is made using linear regression models and regression trees. Results suggest that the average payoff for auctioneers (the search engines) and bidders (the advertisers), the price for each position, and first bidder's payment, are significantly different in the GSP and VCG mechanisms. We also found the mechanism that generates the highest payoff for the search engine is the VCG, while for the bidders it is the GSP.

Abstract
As the major cause of deaths worldwide, cardiovascular diseases are responsible for about 17.9 million deaths per year 1. Research on new technologies and methodologies allowed the acquisition of reliable data in several high income countries, however, in various developing countries, due to poverty and common scarcity of resources, this has not been reached yet. In this work, cardiovascular data acquired using cardiac auscultation is going to be used to detect cardiac murmurs through an innovative deep learning approach. The proposed screening algorithm was built using pre-trained models comprising Residual Neural Networks, namely Resnet50, and Visual Geometry Groups, such as VGG16 and VGG19. Furthermore, and up to our knowledge, our proposal is the first one that characterizes heart murmurs based on their frequency components, i.e. the murmur pitch. Such analysis may be used to augment the system's capability on detecting heart diseases. A novel decision-making function was also proposed regarding the murmur's pitch. From our experiments, low-pitch murmurs were more difficult to detect, with final f1-score values nearing the 0.40 value mark for all three models, while high-pitch murmurs presented an higher f1-score value of about 0.80. This might be due to the fact that the low-pitch share their respective frequency range with the normal and fundamental heart sounds, therefore making it harder for the model to correctly detect their presence whereas high-pitch murmurs' frequencies distance from the latter.

Abstract
The rapid growth of the scientific literature makes text classification essential specially in the biomedical research domain to help researchers to focus on the latest findings in a fast and efficient way. The potential benefits of using text semantic enrichment to enhance the biomedical document classification is presented in this study. We show the importance of enriching the corpora with semantic information to improve the full-text classification. The approach involves the semantic enrichment of a Medline corpus with a Semantic Repository (SemRep) which extracts semantic predications from biomedical text. The study also addresses the problem of treating highly dimensional data while maintaining the semantic structure of the corpus. Experimental results lead to the sustained conclusion that better results are achieved with full-text instead of using only abstracts and titles. We also conclude that the application of enriched techniques to full-texts significantly improves the task of text classification providing a significant contribution for the biomedical text mining research.

Abstract
The work reported in this article addresses the challenge of building models for non-trivial aerobatic aircraft maneuvers in an automated fashion. It is built using a Behavioural Cloning approach where human pilots provide a set of example maneuvers used by a Machine Learning algorithm to induce a control model for each maneuver. The best examples for each maneuver were selected using a set of objective evaluation metrics. Using those example sets, robust models were induced that could replicate (and in some cases outperform) the human pilots that provided the examples (the clean-up effect). Complete complex maneuvers were performed using a meta-controller capable of sequencing the basic ones learned by imitation. This endeavor was rewarded by the results that show several Machine Learning models capable of performing highly complex aircraft maneuvers.

Abstract
This article reports on the development of a Web platform for the study of Adverse Drug Events (ADEs). The platform is able to import ADE episodes from official Web sites, like OpenFDA, analyse the chemistry of the drugs involved, together with patient data, and produce a potential explanation based on the drugs interactions. Each study uses chemical knowledge to enrich the information on the molecules involved in the episodes. Data Mining is then used to construct models that can help in the explanation of the ADE occurrence and to predict future events. This paper reports on the Web portal developed and the Data Mining experiments conducted to evaluate the quality, and potential explanations of the forecasted adverse reactions, using real reports of drug administration and the subsequent adverse events. The results showed that it was possible to predict the outcomes of ADEs based on the structure of the molecules of the drugs involved and the data collected from real reports of drug administration up to an accuracy of 79%, while also predicting, with high accuracy, the severity of events where the outcome is the death of the patient (with a precision of 98.9%). The platform provides a less expensive and more accurate way of predicting adverse drug reactions compared to traditional methods. This study highlights the importance of understanding drug interactions at a molecular level and the usefulness of utilising Data Mining techniques in predicting ADEs.