Abstract
Considering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI). For this, we propose a deep learning (DL) system that learns from weak labels, a sampling strategy that reduces the number of training samples by a factor of six without compromising performance, an approach to leverage a small subset of fully annotated samples, and a prototype with explainable predictions, active learning features and parallelisation. Noting some problems in the literature, this study is conducted with one of the largest WSI colorectal samples dataset with approximately 10,500 WSIs. Of these samples, 900 are testing samples. Furthermore, the robustness of the proposed method is assessed with two additional external datasets (TCGA and PAIP) and a dataset of samples collected directly from the proposed prototype. Our proposed method predicts, for the patch-based tiles, a class based on the severity of the dysplasia and uses that information to classify the whole slide. It is trained with an interpretable mixed-supervision scheme to leverage the domain knowledge introduced by pathologists through spatial annotations. The mixed-supervision scheme allowed for an intelligent sampling strategy effectively evaluated in several different scenarios without compromising the performance. On the internal dataset, the method shows an accuracy of 93.44% and a sensitivity between positive (low-grade and high-grade dysplasia) and non-neoplastic samples of 0.996. On the external test samples varied with TCGA being the most challenging dataset with an overall accuracy of 84.91% and a sensitivity of 0.996.

Abstract
Rising adoption of AI-driven solutions in medical imaging is associated with an emerging need to develop strategies to introduce explainability as an important aspect of trustworthiness of AI models. This chapter addresses the most commonly used explainability techniques in medical image analysis, namely methods generating visual, example-based, textual, and concept-based explanations. To obtain visual explanations, we explore backpropagation- and perturbation-based methods. To yield example-based explanations, we focus on prototype-, distance-, and retrieval-based techniques, as well as counterfactual explanations. Finally, to produce textual and concept-based explanations, we delve into image captioning and testing with concept activation vectors, respectively. This chapter aims at providing understanding of the conceptual underpinning, advantages and limitations of each method, as well as to interpret their generated explanations in the context of medical image analysis.

Abstract
Context. The amount of adaptive optics (AO) telemetry generated by visible/near-infrared ground-based observatories is ever greater, leading to a growing need for a standardised data exchange format to support performance analysis, AO research, and development activities that involve large-scale telemetry mining, processing, and curation. Aims. This paper introduces the Adaptive Optics Telemetry (AOT) data exchange format as a standard for sharing AO telemetry from visible/infrared ground-based observatories. AOT is based on the flexible image transport system (FITS) and aims to provide unambiguous and consistent data access across various systems and configurations, including natural and single- or multiple-laser guide-star AO systems. Methods. We designed AOT with a focus on two key use cases: atmospheric turbulence parameter estimation and point-spread function reconstruction. We prototyped and tested the design using existing AO telemetry datasets from multiple systems: single conjugate with natural and laser guide stars, tomographic systems with multi-channel wavefront sensors, and single- and multi-wavefront correctors in systems featuring either a Shack-Hartmann or Pyramid as the main wavefront sensor. Results. The AOT file structure has been thoroughly defined, with specified data fields, descriptions, data types, units, and expected dimensions. To support this format, we have developed a Python package that enables the data conversion, reading, writing, and exploration of AOT files; it has been made publicly available and is compatible with a general-purpose Python package manager. We have demonstrated the flexibility of the AOT format by packaging data from five different instruments, installed on different telescopes.

Abstract
The GNAO facility is an upcoming adaptive optics (AO) system for the Gemini North Telescope. It will deliver both wide and narrow field AO capabilities to its first light instrument GIRMOS. GIRMOS is a multi-object AO (MOAO) instrument that houses four near infrared (NIR) IFU spectrographs and a NIR imager similar to GSAOI at Gemini South. The required sensitivity of the combined system is largely driven by rapid transient followup AO-corrected Imaging and the required sensitivity is in part driven by the performance of the AO system. Up until recently, the estimated AO performance feeding the combined GNAO+GIRMOS imaging system was derived from models using limited information on what the actual parameters will eventually be. However, the AO system (currently called the AO Bench, or AOB) recently underwent a competitive bidding process to derive an AO design that met or exceeded our AO requirements. This work summarizes the update to the combined GNAO+GIRMOS imaging system performance based on the newly designed AOB parameters. We discuss the impact due to the changes in performance, specifically with respect to key science cases of the GNAO+GIRMOS imaging system compared to the previous models of the AO system. We also discuss the largest hurdles in terms of parameters that affect performance, such as telescope vibrations and detector quantum efficiency and our plans for mitigation.

Abstract
METIS, the Mid-infrared ELT Imager and Spectrograph, will be one of the first instruments to be used at ESO's 39m Extremely Large Telescope (ELT), that is currently under construction. With that, a number of firsts are to be addressed in the development of METIS' single-conjugate Adaptive Optics (SCAO) system: the size of the telescope and the associated complexity of the wavefront control tasks, the unique scientific capabilities of METIS, including high contrast imaging, the interaction with the newly established, integrated wavefront control infrastructure of the ELT, the integration of the near-infrared Pyramid Wavefront Sensor and other key Adaptive Optics (AO) hardware embedded within a large, fully cryogenic instrument. METIS and it's AO system have passed the final design review and are now in the manufacturing, assembly, integration and testing phase. The firsts are approached through a compact hard- and software design and an extensive test program to mature METIS SCAO before it is deployed at the telescope. This program includes significant investments in test setups that allow to mimic conditions at the ELT. A dedicated cryo-test facility allows for subsystem testing independent of the METIS infrastructure. A telescope simulator is being set up for end-to-end laboratory tests of the AO control system together with the final SCAO hardware. Specific control algorithm prototypes will be tested on sky. In this contribution, we present the progress of METIS SCAO with an emphasis on the preparation for the test activities foreseen to enable a successful future deployment of METIS SCAO at the ELT.

Abstract
METIS, the Mid-Infrared ELT Imager and Spectrograph is a first-generation ELT instrument scheduled to see first light in 2029. Its two main science modules are supported by an adaptive optics system featuring a pyramid sensor with 90x90 sub-apertures working in H- and K-band. The wavefront control concept for METIS' singleconjugate adaptive optics relies on a synthetic calibration that uses a model of the telescope and instrument to generate the interaction and control matrices, as well as the final projection on a modal command vector. This concept is enforced owing to the absence of a calibration source in front of the ELT's main deformable mirror. The core of the synthetic calibration functionality is the Command Matrix Optimiser module, which consists of several components providing models for various parts and aspects of the instrument, as well as the entire reconstructor. Many are present in the simulation environment used during the design phases, but need to be re-written and/or adapted for real-life use. In this paper, we present the design of the full command matrix optimisation module, the status of these efforts and the overall final concept of METIS' soft real-time system.